Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Serghei Chercheja"'
Autor:
Javier Garcia Fernandez, Anna Warnecke, Serghei Chercheja, Heidi-Kristin Walter, Lara Pes, Felix Kratz, Federico Medda, Friederike I. Nollmann, Didier Rognan, Steffen Daum, Khalid Abu Ajaj, Patricia Perez Galan, Magnusson Johannes Pall, Koester Stephan David
Publikováno v:
Journal of Controlled Release. 296:81-92
Auristatins are a class of highly cytotoxic tubulin-disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials. In our continuing effort to develop acid-sensitive albumin-binding anticancer drugs exploiting cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3b07851396b9736b65ff1737d620a1
https://doi.org/10.1016/j.jconrel.2019.01.010
https://doi.org/10.1016/j.jconrel.2019.01.010
Publikováno v:
Organicbiomolecular chemistry. 17(46)
Singlet oxygen (1O2) plays an important role in human innate immune response, plant physiology and anticancer photodynamic therapy (PDT). Therefore, its monitoring by convenient and sensitive methods (e.g. by detecting a fluorescence signal) by using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09fc7e679af6d885d13cc07ac5b22a9
https://pubmed.ncbi.nlm.nih.gov/31710325
https://pubmed.ncbi.nlm.nih.gov/31710325
Autor:
Siegfried Eigler, Hanna Pieper, Milos R. Filipovic, Serghei Chercheja, Andriy Mokhir, Christian E. Halbig
Publikováno v:
Angewandte Chemie. 128:413-416
Potentielle biomedizinische Anwendungen von Graphenoxid (GO), z. B. als Trager von Biomolekulen, Reagentien fur die photothermische Therapie oder Biosensoren, werden durch die Zytotoxizitat und Mutagenitat dieses Materials eingeschrankt. Es wird davo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183242738ae4889541da83c25768eb02
https://doi.org/10.1002/ange.201507070
https://doi.org/10.1002/ange.201507070
Autor:
Ivo Starý, David Šaman, Petr Sehnal, Serghei Chercheja, Peter Eilbracht, Zuzana Krausová, Bojan P. Bondzic, Irena G. Stará
Publikováno v:
European Journal of Organic Chemistry. 2011:3849-3857
Starting from the optically pure [6]helicene-like alcohol(P,3S)-3-methyl-4-(4-methylphenyl)-1,3,6,7-tetrahydrobenzo[c]benzo[5,6]phenanthro[4,3-e]oxepin-14-ol, four helical phosphites were prepared from the corresponding chlorophosphites. These ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::115b08ae9244509e245079a982cb46f0
https://doi.org/10.1002/ejoc.201100259
https://doi.org/10.1002/ejoc.201100259
Publikováno v:
Tetrahedron. 67:3839-3845
A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe–Ziegler cyclizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d03e5e3d04823f800b2bbd3fd6b43174
https://doi.org/10.1016/j.tet.2011.03.098
https://doi.org/10.1016/j.tet.2011.03.098
Autor:
Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi-Kristin Walter, Serghei Chercheja, Anna Warnecke, Lara Pes, Patricia Perez Galan, Magnusson Johannes Pall, Friederike I. Nollmann, Khalid Abu Ajaj, Koester Stephan David
Publikováno v:
Cancer Research. 78:3703-3703
Auristatins are highly cytotoxic antimitotic tubulin-binding peptides. Of this family, only Adcetris®, an antibody drug conjugate (ADC) derived from monomethyl auristatin E (MMAE), is approved and marketed. Other auristatins such as dolastatin 10, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7469cf806f1784d973caebf1dfe7eef
https://doi.org/10.1158/1538-7445.am2018-3703
https://doi.org/10.1158/1538-7445.am2018-3703
Autor:
Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi K. Walter, Friederike I. Nollmann, Lara Pes, Magnusson Johannes Pall, Koester Stephan David, Patricia Perez Galan, Khalid Abu Ajaj, Serghei Chercheja, Anna Warnecke
Publikováno v:
Cancer Research. 78:1657-1657
Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis.1 Unfortunately, their narrow therapeutic window prevents a clinical application of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466f9ca4145cfa741a9f3a066beaeb70
https://doi.org/10.1158/1538-7445.am2018-1657
https://doi.org/10.1158/1538-7445.am2018-1657
Autor:
Javier Garcia Fernandez, Lara Pes, Heidi K. Walter, Friederike I. Nollmann, Federico Medda, Magnusson Johannes Pall, Felix Kratz, Anna Warnecke, Koester Stephan David, Serghei Chercheja, Patricia Perez Galan, Khalid Abu Ajaj
Publikováno v:
Cancer Research. 78:2661-2661
Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis. Their potent anticancer activity made them attractive for drug development.1 Unfortun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f3ca8028e33eeb29be5711cb138dc59
https://doi.org/10.1158/1538-7445.am2018-2661
https://doi.org/10.1158/1538-7445.am2018-2661
Publikováno v:
Advanced Synthesis & Catalysis. 352:637-643
This work reports the possibility of controlling the sense of enantio- and diastereoinductions in the sequential hydroformylation and aldol reactions via the judicious combination of a chiral metal catalyst with a chiral organocatalyst. The diastereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d33f340abb746956562293d785d38ebc
https://doi.org/10.1002/adsc.200900780
https://doi.org/10.1002/adsc.200900780
Publikováno v:
Advanced Synthesis & Catalysis. 351:339-344
Metal-catalysed hydroformylation is successfully combined with an organocatalysed stereoselective Mannich reaction in a tandem reaction sequence. This novel type of "tandem catalysis" allows access to complex molecular systems with high levels of ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9efd7ac6fc265688b63b76d99b794d4
https://doi.org/10.1002/adsc.200800720
https://doi.org/10.1002/adsc.200800720