Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

Autor: Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115428 (2014)

Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder B

Externí odkaz: https://doaj.org/article/7a0ab1bfe3da408a9947ed313aba301e

Dimeric α-Cobratoxin X-ray Structure

Autor: Victor I. Tsetlin, Prakash Rucktooa, Daniel Bertrand, Alexey V. Osipov, Yuri N. Utkin, Igor E. Kasheverov, Vladislav G. Starkov, Titia K. Sixma, Sergey Yu. Filkin, T. V. Andreeva

Publikováno v: Journal of Biological Chemistry. 287:6725-6734

In Naja kaouthia cobra venom, we have earlier discovered a covalent dimeric form of α-cobratoxin (αCT-αCT) with two intermolecular disulfides, but we could not determine their positions. Here, we report the αCT-αCT crystal structure at 1.94 Å

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f57e93ecd97214c4ee6dbbdb9d08199
https://doi.org/10.1074/jbc.m111.322313

A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom

Autor: Alexey V. Osipov, Sergey Yu. Filkin, Victor I. Tsetlin, Yana V. Makarova, Yuri N. Utkin

Publikováno v: Toxicon. 55:186-194

Thrombin is a key enzyme in the blood coagulation cascade and is also involved in carcinogenesis; therefore, its inhibitors are of fundamental and clinical importance. Snake venoms are widely used as sources of proteins that affect blood coagulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cd4d0e6e4f76f2673fea550db7fb2e
https://doi.org/10.1016/j.toxicon.2009.07.011

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2

Autor: Maxim E. Astashev, T. V. Andreeva, Alexey V. Osipov, Victor I. Tsetlin, Vladislav G. Starkov, Igor E. Kasheverov, Yuri N. Utkin, Catherine A. Vulfius, Sergey Yu. Filkin, Elena V. Gorbacheva

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115428 (2014)
PLoS ONE

Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d103fdc37f4a1fe01c83e70f1cf1db3e
https://doaj.org/article/7a0ab1bfe3da408a9947ed313aba301e

Article Aversion to Nicotine Is Regulated by the Balanced Activity of b4 and a5 Nicotinic Receptor Subunits in the Medial Habenula

Autor: Beatriz Antolin-Fontes, Silke Frahm, Leiron Ferrarese, Stéphanie Pons, Inés Ibañez-Tallon, Victor I. Tsetlin, Sergey Yu. Filkin, Marta A. Ślimak, Sebastian Auer, Julio Santos-Torres, Jean-Fred Fontaine, Uwe Maskos

Publikováno v: Neuron
Neuron, 2011, 70 (3), pp.522-535. ⟨10.1016/j.neuron.2011.04.013⟩
Neuron, Elsevier, 2011, 70 (3), pp.522-535. ⟨10.1016/j.neuron.2011.04.013⟩

International audience; Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the a3b4a5 nicotinic acetyl-choline receptor (nAChR). Here we show that the b4 subunit is rate limiting for rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2654c695422849a97115b7268bb8cfba
https://hal-pasteur.archives-ouvertes.fr/pasteur-02936508