Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation

Autor: Sergey Savitskiy, Rudolf Wachtel, Danial Pourjafar-Dehkordi, Hyun-Seo Kang, Vanessa Trauschke, Don C. Lamb, Michael Sattler, Martin Zacharias, Aymelt Itzen

Publikováno v: iScience, Vol 24, Iss 1, Pp 101940- (2021)

Summary: Rab GTPases are central regulators of intracellular vesicular trafficking. They are frequently targeted by bacterial pathogens through post-translational modifications. Salmonella typhimurium secretes the cysteine protease GtgE during infect

Externí odkaz: https://doaj.org/article/54b015bc474e49a788f63f6a048963d6

SopD from Salmonella specifically inactivates Rab8

Autor: Aymelt Itzen, Sergey Savitskiy

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1869:140661

Salmonella outer protein D (SopD) is secreted into a host during the first stages of the Salmonella infection and contributes to the systemic virulence of the bacterium. SopD2 is a SopD homolog and possesses GTPase activating protein (GAP) activity t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fbc8afd1600fce94f3d4c893ad8116
https://doi.org/10.1016/j.bbapap.2021.140661

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

Autor: Anna-Carin, Hoffmann, Georgia, Minakaki, Stefanie, Menges, Rachele, Salvi, Sergey, Savitskiy, Aida, Kazman, Hugo, Vicente Miranda, Dirk, Mielenz, Jochen, Klucken, Jürgen, Winkler, Wei, Xiang

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Cell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play an important role in the progression of alpha synucleinopathies. A critical step for the propagation process is the accumulation of extracellular aSyn within rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b7bd329820a0a8239b55c6970ba4b52
http://www.scopus.com/inward/record.url?scp=85060517881&partnerID=8YFLogxK

PS 11-55 CORRELATION RELATIONSHIP HOMA INDEX WITH BLOOD PRESSURE, HEART RATE AND LIPID IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC SYNDROME WITHOUT DIABETES TREATED DIFFERENT BETA BLOCKERS

Autor: Olga Mironova, Sergey Savitskiy, E. Pavlyuk, S.A. Polishchuk, V. Granich, P. Sidorenko, Yuriy Sirenko, Oksana Rekovets, G. Primak, Olena Torbas, Alla Vashchylko

Publikováno v: Journal of Hypertension. 34:e349

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e34d703efb2bc5a1eebba2d21cb988e7
https://doi.org/10.1097/01.hjh.0000500887.26865.e3