Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sergey S. Akimov"'
Autor:
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevat
Externí odkaz:
https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
Autor:
Chelsy R Eddings, Ernest Fraenkel, Mali Jiang, C. Conover Talbot, Paul T. Ranum, Lauren R. DeVine, Robert N. Cole, Emma Whelan, Anthony Tang, Amanda J. Kedaigle, Leonard O Marque, Beverly L. Davidson, Ronald Wang, Nicolas Arbez, Tamara Ratovitski, Christopher A. Ross, Sergey S Akimov
Publikováno v:
Prof. Fraenkel
Hum Mol Genet
Hum Mol Genet
We have previously established induced pluripotent stem cell (iPSC) models of Huntington’s disease (HD), demonstrating CAG-repeat-expansion-dependent cell biological changes and toxicity. However, the current differentiation protocols are cumbersom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1865400d87031d19ad0d1a4727da4586
https://doi.org/10.1093/hmg/ddab200
https://doi.org/10.1093/hmg/ddab200
Autor:
Mark Ren, Elaine Roby, Christopher A. Ross, Sergey S Akimov, Xiaofang Wang, Nicolas Arbez, Chelsy R Eddings
Publikováno v:
Journal of Huntington's Disease. 8:129-143
Background The potential benefit of cysteamine for Huntington's disease has been demonstrated in HD animal models. Cysteamine and its derivate cystamine were shown to reduce neuropathology and prolong lifespan. Human studies have demonstrated safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7cab0912d04ac8bf79b6ff219d1c21f
https://doi.org/10.3233/jhd-180312
https://doi.org/10.3233/jhd-180312
Autor:
Ni Arbez, Chelsy R Eddings, Mark Ren, Christopher A. Ross, Elaine Roby, Sergey S Akimov, Xiaofang Wang
Publikováno v:
Journal of Huntington's disease. 9(3)
BACKGROUND: The potential benefit of cysteamine for Huntington’s disease has been demonstrated in HD animal models. Cysteamine and its derivate cystamine were shown to reduce neuropathology and prolong lifespan. Human studies have demonstrated safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1179e149a8b5216ca1cf37f5855be6b2
https://pubmed.ncbi.nlm.nih.gov/30856117
https://pubmed.ncbi.nlm.nih.gov/30856117
Autor:
Julia A. Kaye, Malcolm Casale, Ping H Wang, Steven Finkbeiner, Yumay Chen, Ryan G. Lim, Ernest Fraenkel, Min Wu, Alvin R. King, Leslie M. Thompson, Jennifer Stocksdale, Marcy E. MacDonald, Virginia B. Mattis, Nicolas Arbez, Tamara Ratovitski, Clive N. Svendsen, Christopher A. Ross, Amanda J. Kedaigle, James F. Gusella, Colton M Tom, Ranjit Singh Atwal, Sergey S Akimov
Publikováno v:
Human Molecular Genetics
Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington’s disease (HD). Research has primarily focused on mitochondrial toxicity, which can cause death of the vulnerable st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba2a92baf49dc7f08b70392e7573cf
https://pubmed.ncbi.nlm.nih.gov/30768179
https://pubmed.ncbi.nlm.nih.gov/30768179
Autor:
Kunal R. Sampat, Audrey S. Dickey, Cynthia Hsu, Ronald M. Evans, Eliezer Masliah, Stephen K. Gilmore-Hall, Christopher A. Ross, Dafne N. Sanchez, Kohta Ohnishi, Nicole S. Lomas, Donald C. Lo, Albert R. La Spada, Janice M. Nguyen, Nicolas Arbez, April L. Flores, Weiwei Fan, Martin Arreola, Michael J. Van Kanegan, Sergey S Akimov
Publikováno v:
Science translational medicine. 9(419)
Neurons must maintain protein and mitochondrial quality control for optimal function, an energetically expensive process. The peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription factors that promote mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97acd35e6e8c1914cba77fbde810af63
https://pubmed.ncbi.nlm.nih.gov/29212711
https://pubmed.ncbi.nlm.nih.gov/29212711
Autor:
Terry Gaasterland, Bryce L. Sopher, Audrey S. Dickey, Gavin Magnuson, Taiji Tsunemi, Kunal R. Sampat, Eduardo R. Lazarowski, Patrick Liu, Stephen K. Gilmore-Hall, Victor V. Pineda, Eliezer Masliah, Albert R. La Spada, Nicolas Arbez, Gene W. Yeo, Martin Arreola, Nicole S. Lomas, Mark Joseph Manalang Torres, Anthony B. Pinkerton, April L. Flores, Helen C. Miranda, Christopher A. Ross, Anne Buttgereit, Sergey S Akimov
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which encodes a polyglutamine tract in the HTT protein. We found that peroxisome proliferator-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0f029f51f2c94742e91edb056cc65e
Autor:
Sergey S. Akimov, Carroll McKenzie, David M. Asher, Larisa Cervenakova, Pedro Piccardo, Juraj Cervenak, Irina Vasilyeva, Oksana Yakovleva
Publikováno v:
Transfusion. 51:1755-1768
BACKGROUND: The possible risk of iatrogenic transmissible spongiform encephalopathies (TSEs, prion diseases) from transplantation of marrow-derived mesenchymal stem cells (MSCs) is uncertain. While most cell lines resist infection, a few propagate TS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f864c3f0a55d4fd00e09043cbfa574bf
https://doi.org/10.1111/j.1537-2995.2010.03041.x
https://doi.org/10.1111/j.1537-2995.2010.03041.x
Publikováno v:
STEM CELLS. 23:1423-1433
We attempted to extend the lifespan of CD34+ stem/progenitor cells in human cord blood (CB) by transduction with lentiviral vectors carrying the human telomerase catalytic subunit (hTERT) and/or the human papillomavirus type 16 (HPV16) E6 and E7 onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b54084d4743ec0c403e097d928190b
https://doi.org/10.1634/stemcells.2005-0390
https://doi.org/10.1634/stemcells.2005-0390
Autor:
Christopher A. Ross, Sergey S Akimov
The cell biology of human neurodegenerative diseases has been difficult to study till recently. The development of human induced pluripotent stem cell (iPSC) models has greatly enhanced our ability to model disease in human cells. Methods have recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a65be0a2c7b0cc13d6df8689f977cc
https://europepmc.org/articles/PMC4170718/
https://europepmc.org/articles/PMC4170718/