Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sergey S Novoselov"'
Autor:
Sergey S Novoselov, Wendy J Mustill, Anna L Gray, James R Dick, Naheed Kanuga, Bernadett Kalmar, Linda Greensmith, Michael E Cheetham
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73944 (2013)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS
Externí odkaz:
https://doaj.org/article/6140c0a7d75a40038a7cefb6e229cde6
Autor:
Sunaina Surana, David Villarroel-Campos, Chiara Panzi, Sergey S. Novoselov, Sandy Richter, Giuseppe Zanotti, Giampietro Schiavo
Tetanus toxin is one of the most potent neurotoxins and is the causative agent of tetanus. This neurotoxin binds to the neuromuscular junction and, after internalisation into motor neurons, undergoes long-distance axonal transport and transcytosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d05b143466cd358754fbb2f64c652cc6
https://doi.org/10.1101/2023.02.03.526966
https://doi.org/10.1101/2023.02.03.526966
Publikováno v:
Toxicon. 190:S71-S72
Autor:
Giampietro Schiavo, Andrew P. Tosolini, Sergey S. Novoselov, Alexander D. Fellows, Ione Meyer, Sunaina Surana
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 147
Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus and botulism, respectively, are the most potent toxic molecules known to mankind. This extreme potency is attributed to: i) their specificity for essential components of
Autor:
Michael E. Cheetham, David A. Parfitt, Dimitra Athanasiou, Dalila Bevilacqua, Mònica Aguilà, Sergey S. Novoselov
Publikováno v:
FEBS Letters. 587:2008-2017
Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeost
Autor:
Adrienne W. Paton, Maria Kosmaoglou, James C. Paton, Dimitra Athanasiou, Sergey S. Novoselov, Naheed Kanuga, Chapple Jp, Michael E. Cheetham
Publikováno v:
Molecular Biology of the Cell
Misfolding mutations in rod opsin cause the blinding disease retinitis pigmentosa. The ER chaperone BiP is required to prevent rod opsin aggregation, and overexpression of BiP can improve mutant rod opsin mobility. This could be important for therapi
Autor:
Sergey S. Novoselov, Anna Gray, Bernadett Kalmar, Michael E. Cheetham, Boris Margulis, Linda Greensmith
Publikováno v:
Journal of Neurochemistry. 107:339-350
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motoneuron degeneration, resulting in muscle paralysis and death, typically within 1-5 years of diagnosis. Although the pathogenesis of ALS remains uncle
Autor:
Sergey S. Novoselov, Irina V. Guzhova, Jacqueline van der Spuy, Alexander M. Sapozhnikov, Tatiana V. Novoselova, Boris A. Margulis, Michael E. Cheetham
Publikováno v:
Journal of Neurochemistry. 94:597-606
The accumulation of insoluble protein aggregates is a feature of neurodegenerative disease. Overexpression of Heat Shock Protein 70 (HSP70) can protect cells with protein aggregates from apoptosis. Another trait of HSP70 is its ability to cross the p
Autor:
Linda Greensmith, Anna L. Gray, Naheed Kanuga, Bernadett Kalmar, James R. T. Dick, Wendy J. Mustill, Michael E. Cheetham, Sergey S. Novoselov
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e73944 (2013)
PLoS ONE, Vol 8, Iss 8, p e73944 (2013)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS
Autor:
Diane P. Hanger, Teresa Rodriguez, Gunter Schmidtke, Jacqueline van der Spuy, Michael E. Cheetham, Sergey S. Novoselov, Marcus Groettrup, Emma Richet, Amy M. Pooler
Abnormal phosphorylation of the microtubule-associated protein tau in neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal lobar degeneration, is associated with disrupted axonal transport and synaptic dysfunction ultima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6796fe9dfa54434515d7b43cc083e77