Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sergey Reverdatto"'
Autor:
Nicholas Sciolino, Sergey Reverdatto, Aaron Premo, Leonard Breindel, Jianchao Yu, Gregory Theophall, David S. Burz, Anna Liu, Todd Sulchek, Ann Marie Schmidt, Ravichandran Ramasamy, Alexander Shekhtman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Analytical tools to study cell physiology are critical for optimizing drug-host interactions. Real time pulse chase NMR spectroscopy, RTPC-NMR, was introduced to monitor the kinetics of metabolite production in HEK 293T cells treated with CO
Externí odkaz:
https://doaj.org/article/596fe7d7b2be492f8d0a909edb501da5
Autor:
Lander Egaña-Gorroño, Raquel López-Díez, Gautham Yepuri, Lisa S. Ramirez, Sergey Reverdatto, Paul F. Gugger, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although extensive strides have been made in the treatments for non-diabetic atherosclerosis and its complications, for patients with diabetes, these therapies provide
Externí odkaz:
https://doaj.org/article/57b885d982324f2dbf9cd251e3c54370
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74576 (2013)
The Mycobacterium tuberculosis proteasome is required for maximum virulence and to resist killing by the host immune system. The prokaryotic ubiquitin-like protein, Pup-GGE, targets proteins for proteasome-mediated degradation. We demonstrate that Pu
Externí odkaz:
https://doaj.org/article/6ed04d052bc44f2f977170003555ade9
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65180 (2013)
Peptide aptamers are small proteins containing a randomized peptide sequence embedded into a stable protein scaffold, such as Thioredoxin. We developed a robust method for building a Combinatorial Library of Improved Peptide aptamers (CLIPs) of high
Externí odkaz:
https://doaj.org/article/4f258d2221a34cfe809aac64924a08e1
Autor:
Laura Frye, Jinhong Pan, Alexander Shekhtman, Ann Marie Schmidt, Michaele B. Manigrasso, Boyan Zhou, Ravichandran Ramasamy, Sergey Reverdatto, Lander Egaña-Gorroño, Huilin Li, Lisa S. Ramirez, Robert J. DeVita, Nosirudeen Quadri, Piul Rabbani, Vivette D. D'Agati, Stephen Dansereau
Publikováno v:
Sci Transl Med
The macro- and microvascular complications of type 1 and 2 diabetes lead to increased disease severity and mortality. The receptor for advanced glycation end products (RAGE) can bind AGEs and multiple proinflammatory ligands that accumulate in diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865628443890a051f5a296b652565acd
https://europepmc.org/articles/PMC8669775/
https://europepmc.org/articles/PMC8669775/
Autor:
Alexander Shekhtman, Sergey Reverdatto, Ann Marie Schmidt, Lander Egaña-Gorroño, Raquel López-Díez, Gautham Yepuri, Paul F. Gugger, Ravichandran Ramasamy, Lisa Ramirez
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although extensive strides have been made in the treatments for non-diabetic atherosclerosis and its complications, for patients with diabetes, these therapies provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7671869b6d567f46dd70d3fc219f6852
https://doi.org/10.3389/fcvm.2020.00037
https://doi.org/10.3389/fcvm.2020.00037
Autor:
Sergey Reverdatto, Christopher M. DeMott, Roxie C. Girardin, Alexander Shekhtman, David S. Burz, Jacqueline Cobbert, Kathleen A. McDonough
Publikováno v:
ACS Chemical Biology. 13:733-741
In-cell NMR spectroscopy was used to screen for drugs that disrupt the interaction between prokaryotic ubiquitin like protein, Pup, and mycobacterial proteasome ATPase, Mpa. This interaction is critical for Mycobacterium tuberculosis resistance again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463c8d63332fd3c622d211f882a5cccd
https://doi.org/10.1021/acschembio.7b00879
https://doi.org/10.1021/acschembio.7b00879
Autor:
Sergey Reverdatto, Christopher M. DeMott, Alexander Shekhtman, David S. Burz, Subhabrata Majumder
Publikováno v:
Biochemistry. 56:4117-4126
Ribosomes are present inside bacterial cells at micromolar concentrations and occupy up to 20% of the cell volume. Under these conditions, even weak quinary interactions between ribosomes and cytosolic proteins can affect protein activity. By using i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716cb70e1b554777b1f420fd3df5e47d
https://doi.org/10.1021/acs.biochem.7b00613
https://doi.org/10.1021/acs.biochem.7b00613
Autor:
Jing Xue, Daniele Fabris, Matteo Scalabrin, Vivek Rai, Ann Marie Schmidt, David S. Burz, Michaele B. Manigrasso, Sergey Reverdatto, Alexander Shekhtman
Publikováno v:
Structure
Datacite
Europe PubMed Central
Elsevier
PubMed Central
UnpayWall
ORCID
Microsoft Academic Graph
Datacite
Europe PubMed Central
Elsevier
PubMed Central
UnpayWall
ORCID
Microsoft Academic Graph
The weak oligomerization exhibited by many transmembrane receptors has a profound effect on signal transduction. The phenomenon is difficult to characterize structurally due to the large sizes of and transient interactions between monomers. The recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473060bab2f237b76197363a669ec033
Autor:
Christopher M. DeMott, David S. Burz, Sergey Reverdatto, Subhabrata Majumder, Alexander Shekhtman
Publikováno v:
Biochemistry. 55:4568-4573
RNA constitutes up to 20% of a cell’s dry weight, corresponding to ~20 mg/mL. This high concentration of RNA facilitates low-affinity protein–RNA quinary interactions, which may play an important role in facilitating and regulating biological pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bed32ba9bc869bb88f62d100a88e02c
https://doi.org/10.1021/acs.biochem.6b00330
https://doi.org/10.1021/acs.biochem.6b00330