Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sergey Pshenichkin"'
Autor:
Sergey Pshenichkin, Carrie Bowman Dalley, Hannah A. Hathaway, Ewa Grajkowska, Jarda T. Wroblewski, Tara Gelb, Barry B. Wolfe
Publikováno v:
Biochemical Pharmacology. 98:182-189
The metabotropic glutamate 1 (mGlu1) receptor has emerged as a novel target for the treatment of metastatic melanoma and various other cancers. Our laboratory has demonstrated that a selective, non-competitive mGlu1 receptor antagonist slows human me
Autor:
Sergey Pshenichkin, Barry B. Wolfe, Andrew C. Emery, Ewa Grajkowska, Tara Gelb, Hannah A. Hathaway, Jarda T. Wroblewski
Publikováno v:
Neuropharmacology. 93:199-208
The majority of existing research on the function of metabotropic glutamate (mGlu) receptor 1 focuses on G protein-mediated outcomes. However, similar to other G protein-coupled receptors (GPCR), it is becoming apparent that mGlu1 receptor signaling
Autor:
Hannah A. Hathaway, Jarda T. Wroblewski, Eric C. Miller, Barry B. Wolfe, Andrew C. Emery, Sergey Pshenichkin, Ewa Grajkowska, Robert P. Yasuda, John O. DiRaddo, Guy Rodrigue Takoudjou
Publikováno v:
Molecular Pharmacology. 82:291-301
The metabotropic glutamate 1a (mGlu1a) receptor is a G protein-coupled receptor linked with phosphoinositide (PI) hydrolysis and with β-arrestin-1-mediated sustained extracellular signal-regulated kinase (ERK) phosphorylation and cytoprotective sign
Publikováno v:
Journal of Neurochemistry. 63:419-428
Neonatal rat cortical astrocytes in primary culture synthesize and secrete nerve growth factor (NGF). Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased
Autor:
John O. DiRaddo, Hannah A. Hathaway, Jarda T. Wroblewski, Ewa Grajkowska, Barry B. Wolfe, Olga Rodriguez, Tara Gelb, Robert P. Yasuda, Barbara Wroblewska, Sergey Pshenichkin, Chris Albanese
Publikováno v:
Oncogene
Metabotropic glutamate 1 (mGlu) receptor has been proposed as a target for the treatment of metastatic melanoma. Studies have demonstrated that inhibiting the release of glutamate (the natural ligand of mGlu1 receptors), results in a decrease of mela
Autor:
Sergey Pshenichkin, Jarda T. Wroblewski, Jayanta Kumar Mukhopadhyaya, Ewa Grajkowska, Alan P. Kozikowski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1919-1924
The chemical synthesis of a series of N 1 -substituted derivatives of (2 R ,4 R )-4-aminopyrrolidine-2,4-dicarboxylic acid [(2 R ,4 R )-APDC] as constrained analogues of γ-substituted glutamic acids is described. Appropriate substitution of the N 1
Autor:
Gian Luca Araldi, Jarda T. Wroblewski, Sergey Pshenichkin, Werner Tückmantel, Alan P. Kozikowski, Elena Surina
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1721-1726
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced n
Autor:
Werner Tückmantel, Alan P. Kozikowski, Sergey Pshenichkin, Jarda T. Wroblewski, Darryl Hugh Steensma, Gian Luca Araldi, Elena Surina, Shaomeng Wang
Publikováno v:
Journal of Medicinal Chemistry. 41:1641-1650
To better characterize the roles of metabotropic glutamate receptors (mGluRs) in physiological and pathophysiological processes, there is an important need to learn more about the structural features relevant to the design of novel, high-affinity lig
Autor:
Alan P. Kozikowski, Elena Surina, Judith L. Flippen-Anderson, Clifford George, Jarda T. Wroblewski, Sergey Pshenichkin, Gian Luca Araldi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:925-930
A photochemical approach to the synthesis of the aminobicycloheptane 6a is reported. This compound assumes an extended glutamate conformation, and for this reason was created to further probe the structural features relevant to achieving selectivity