Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sergey Pampou"'
Autor:
Ekaterina Royba, Igor Shuryak, Brian Ponnaiya, Mikhail Repin, Sergey Pampou, Charles Karan, Helen Turner, Guy Garty, David J. Brenner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In major radiological events, rapid assays to detect ionizing radiation exposure are crucial for effective medical interventions. The purpose of these assays is twofold: to categorize affected individuals into groups for initial treatments,
Externí odkaz:
https://doaj.org/article/600f4914a27c4250a926c76bb11ff824
Autor:
George Rosenberger, Wenxue Li, Mikko Turunen, Jing He, Prem S. Subramaniam, Sergey Pampou, Aaron T. Griffin, Charles Karan, Patrick Kerwin, Diana Murray, Barry Honig, Yansheng Liu, Andrea Califano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewir
Externí odkaz:
https://doaj.org/article/858e3837977347e38a966598bebfacfc
Autor:
Pasquale Laise, Megan L. Stanifer, Gideon Bosker, Xiaoyun Sun, Sergio Triana, Patricio Doldan, Federico La Manna, Marta De Menna, Ronald B. Realubit, Sergey Pampou, Charles Karan, Theodore Alexandrov, Marianna Kruithof-de Julio, Andrea Califano, Steeve Boulant, Mariano J. Alvarez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Master Regulator proteins, controlling the transcriptional identity of infected cells, can serve as drug targets for inhibiting virus replication, here demonstrated in a SARSCoV-2 infection model.
Externí odkaz:
https://doaj.org/article/2848e83b0ed146a0b6c215d5176e0325
Autor:
Yao Shen, Mariano J Alvarez, Brygida Bisikirska, Alexander Lachmann, Ronald Realubit, Sergey Pampou, Jorida Coku, Charles Karan, Andrea Califano
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005599 (2017)
A large fraction of the proteins that are being identified as key tumor dependencies represent poor pharmacological targets or lack clinically-relevant small-molecule inhibitors. Availability of fully generalizable approaches for the systematic and e
Externí odkaz:
https://doaj.org/article/6ecf5cfe36114ff5b1f0d7cbca44066a
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Index of Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400192d080ba228dd2401397762ff34b
https://doi.org/10.1158/2159-8290.22541971.v1
https://doi.org/10.1158/2159-8290.22541971.v1
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Supplementary Table 3: Transcriptomic analyses of the human patient samples A. TCGA Interactome B. SU2C Interactome C. Protein activity TCGA D. Protein Activity SU2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50152ab5715db26bd60d40e0922dd5e7
https://doi.org/10.1158/2159-8290.22541959
https://doi.org/10.1158/2159-8290.22541959
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b855720c962afe23f44290b02652b77
https://doi.org/10.1158/2159-8290.c.6549772
https://doi.org/10.1158/2159-8290.c.6549772
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Detailed Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4df22845dfdcb9a0c8be4fd4916ec0
https://doi.org/10.1158/2159-8290.22541974
https://doi.org/10.1158/2159-8290.22541974
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Figure S1: Genomic alterations in prostate cancer represented in the GEMMs (related to Fig. 2). Figure S2: Additional phenotypic analyses of the GEMMs (related to Fig. 2). Figure S3: Phenotypic analysis of allograft and organoid models (related to Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadb434fc053ed576194fbc4dad00257
https://doi.org/10.1158/2159-8290.22541968
https://doi.org/10.1158/2159-8290.22541968
Autor:
George Rosenberger, Wenxue Li, Mikko Turunen, Jing He, Prem S Subramaniam, Sergey Pampou, Aaron T Griffin, Charles Karan, Patrick Kerwin, Diana Murray, Barry Honig, Yansheng Liu, Andrea Califano
Publikováno v:
bioRxiv
Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewiring, cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789ee412cc4ea392ab4c0cd8c4abeffd
https://europepmc.org/articles/PMC9949144/
https://europepmc.org/articles/PMC9949144/