Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Sergey N. Mikhailov"'
Autor:
Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Georgy A. Ivanov, Yuri B. Porozov, Anastasia A. Zenchenko, Vladimir E. Oslovsky, Alexandra L. Zakharenko, Darina I. Nasyrova, Galina N. Likhatskaya, Sergey N. Mikhailov, Olga I. Lavrik, Mikhail S. Drenichev
Publikováno v:
Molecules, Vol 27, Iss 8, p 2433 (2022)
Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied. New Tdp1 inhibitors were found in the series of the studied compounds with IC50 = 2.7–6.7 μM. It was sh
Externí odkaz:
https://doaj.org/article/4ad1798b71a34c53a6fa87310fc3e4c9
Autor:
Anastasia O. Komarova, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Irina V. Kulikova, Vladimir E. Oslovsky, Olga D. Zakharova, Alexandra L. Zakharenko, Sergey N. Mikhailov, Olga I. Lavrik
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1415-1429 (2018)
A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors based on disaccharide nucleosides was identified. TDP1 plays an essential role in the resistance of cancer cells to currently used antitumour drugs based on Top1 inhibitors such as topo
Externí odkaz:
https://doaj.org/article/7e913c6c387b42bb8c2b1be76f61b1aa
Autor:
Alexandra L. Zakharenko, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Georgy A. Ivanov, Vladimir E. Oslovsky, Ekaterina S. Ilina, Irina A. Chernyshova, Olga I. Lavrik, Sergey N. Mikhailov
Publikováno v:
Molecules, Vol 25, Iss 16, p 3694 (2020)
Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivat
Externí odkaz:
https://doaj.org/article/029d69dc35444b2bbd700c2f278ee253
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 552 (2020)
Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The le
Externí odkaz:
https://doaj.org/article/5477ad0d38274c7092113cc180e326fd
Autor:
Vladimir E. Oslovsky, Ekaterina M. Savelieva, Mikhail S. Drenichev, Georgy A. Romanov, Sergey N. Mikhailov
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 86 (2020)
The biosynthesis of aromatic cytokinins in planta, unlike isoprenoid cytokinins, is still unknown. To compare the final steps of biosynthesis pathways of aromatic and isoprenoid cytokinins, we synthesized a series of nucleoside derivatives of natural
Externí odkaz:
https://doaj.org/article/2e005918ce284039a58813cd8140040a
Autor:
Vladimir E. Oslovsky, Mikhail S. Drenichev, Liang Sun, Nikolay N. Kurochkin, Vladislav E. Kunetsky, Carmen Mirabelli, Johan Neyts, Pieter Leyssen, Sergey N. Mikhailov
Publikováno v:
Molecules, Vol 22, Iss 7, p 1219 (2017)
Recently, we demonstrated that the natural cytokinin nucleosides N6-isopentenyladenosine (iPR) and N6-benzyladenosine (BAPR) exert a potent and selective antiviral effect on the replication of human enterovirus 71. In order to further characterize th
Externí odkaz:
https://doaj.org/article/d05c342f6a8e4ac1afd1b87b801b61a0
Publikováno v:
Current Medicinal Chemistry. 28:5284-5310
Coronaviruses (CoVs) belong to a large family of zoonotic supercapsid viruses, including about 40 species of RNA-containing viruses with several strains capable of causing damage to the lungs and respiratory tract. The severe acute respiratory syndro
Publikováno v:
Молекулярная биология. 55:897-926
The emergence of new viruses and resistant strains of pathogenic microorganisms has become a powerful stimulus in the search for new drugs. Nucleosides are a promising class of natural compound, and more than a hundred drugs have already been created
Autor:
Irina V, Varizhuk, Vladimir E, Oslovsky, Pavel N, Solyev, Mikhail S, Drenichev, Sergey N, Mikhailov
Publikováno v:
Current Protocols. 2
A simple and efficient method for the preparation of α-D-ribose 1-phosphate and 2-deoxy-α-D-ribose 1-phosphate, key intermediates in nucleoside metabolism and important starting compounds for the enzymatic synthesis of various modified nucleosides,
Autor:
Pavel N. Solyev, Sergey N. Mikhailov, Irina V. Kulikova, Cyrill S. Alexeev, Mikhail S. Drenichev
Publikováno v:
European Journal of Organic Chemistry. 2019:6999-7004