Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sergey Kuranov"'
Autor:
Darya Pon`kina, Sergey Kuranov, Mikhail Khvostov, Nataliya Zhukova, Yulia Meshkova, Mariya Marenina, Olga Luzina, Tatyana Tolstikova, Nariman Salakhutdinov
Publikováno v:
Molecules, Vol 28, Iss 1, p 396 (2023)
Free fatty acid receptor-1 (FFAR1) is one of the possible therapeutic targets in the search for new hepatoprotective drugs. FFAR1 agonists were found to have hypolipidemic, antifibrotic, anti-inflammatory, antiproliferative and antioxidant effects in
Externí odkaz:
https://doaj.org/article/67cb3c41eb75465ab1fb6d55ecc853e9
Autor:
Sergey Kuranov, Mariya Marenina, Dmitriy Ivankin, Mikhail Blokhin, Sergey Borisov, Tatyana Khomenko, Olga Luzina, Mikhail Khvostov, Konstantin Volcho, Tatyana Tolstikova, Nariman Salakhutdinov
Publikováno v:
Molecules, Vol 27, Iss 24, p 8663 (2022)
Natural and synthetic coumarins are often considered privileged scaffolds for obtaining pharmacological agents with hypoglycemic activity. Chemical modification of coumarins often leads to antidiabetic agents with greater efficacy. In the present wor
Externí odkaz:
https://doaj.org/article/90b30d32a34f48f0a43503a8e40e6201
Autor:
Darya Pon`kina, Sergey Kuranov, Nataliya Zhukova, Yulia Meshkova, Mikhail Khvostov, Olga Luzina, Tatyana Tolstikova, Nariman Salakhutdinov
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 1 (2022)
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by impaired lipid and carbohydrate metabolism, and is characterized by fatty degeneration, necrosis, inflammation, and fibrosis of hepatocytes. There are currently no approved
Externí odkaz:
https://doaj.org/article/d1f8b7323d4d47139b0fc732a3100d35
Autor:
Vladislav Fomenko, Mikhail Blokhin, Sergey Kuranov, Mikhail Khvostov, Dmitriy Baev, Marina S. Borisova, Olga Luzina, Tatyana G. Tolstikova, Nariman F. Salakhutdinov
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 1, p 4 (2020)
A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57
Externí odkaz:
https://doaj.org/article/59471e1f87c84364a3bbdfdfd1b3166b
Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
Autor:
Sergey Kuranov, Olga Luzina, Mikhail Khvostov, Dmitriy Baev, Darya Kuznetsova, Nataliya Zhukova, Pavel Vassiliev, Andrey Kochetkov, Tatyana Tolstikova, Nariman Salakhutdinov
Publikováno v:
Pharmaceuticals, Vol 13, Iss 11, p 404 (2020)
A series of bornyl derivatives of p-(benzyloxy)phenylpropionic acid were prepared, and their hypoglycemic activities were examined by an oral glucose tolerance test in mice. The results of this test revealed two compounds, 1 and 3, that can reduce th
Externí odkaz:
https://doaj.org/article/a06c01ce831d4a70a7d6cdd42b496d91
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:972-988
Free fatty acid receptor-1 (FFA1) agonists have been considered for a long time as a potentially new class for the treatment of type 2 diabetes mellitus. Phenylpropanoic acid is the preferred scaffold in the development of FFA1 receptor agonists. Thi
Autor:
Nariman F. Salakhutdinov, Sergey Kuranov, Olga A. Luzina, V. V. Fomenko, Marina S. Borisova, Tatyana G. Tolstikova, M. V. Khvostov, D. S. Baev, Mikhail Blokhin
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 4, p 4 (2021)
Scientia Pharmaceutica
Volume 89
Issue 1
Scientia Pharmaceutica
Volume 89
Issue 1
A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57
Autor:
Darya Kuznetsova, Sergey Kuranov, Mikhail Khvostov, Natalia Zhukova, Olga Luzina, Tatyana Tolstikova
Publikováno v:
Proceedings of 7th International Electronic Conference on Medicinal Chemistry.
Autor:
Nariman F. Salakhutdinov, S. A. Borisov, Sergey Kuranov, M. V. Khvostov, Olga A. Luzina, M. E. Blokhin
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:374-380
A series of amides based on (2S)-cyanopyrrolidine and α, β-unsaturated aryl- and hetarylcarboxylic acids have been synthesized. The dependence of the hypoglycemic activity of compounds on the structure of the aromatic fragment has been studied in t
Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
Autor:
M. V. Khvostov, Pavel M. Vassiliev, D. S. Baev, A. N. Kochetkov, D. A. Kuznetsova, Tatyana G. Tolstikova, Sergey Kuranov, Olga A. Luzina, Nariman F. Salakhutdinov, Nataliya A. Zhukova
Publikováno v:
Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals, Vol 13, Iss 404, p 404 (2020)
Volume 13
Issue 11
Pharmaceuticals, Vol 13, Iss 404, p 404 (2020)
A series of bornyl derivatives of p-(benzyloxy)phenylpropionic acid were prepared, and their hypoglycemic activities were examined by an oral glucose tolerance test in mice. The results of this test revealed two compounds, 1 and 3, that can reduce th