Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sergey Karakashev"'
Autor:
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway
Externí odkaz:
https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde
Autor:
Sergey Karakashev, Rugang Zhang
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
Coactivator-associated arginine methyltransferase 1 (CARM1)-expressing high-grade serous ovarian cancers are characterized by poor prognosis and limited therapeutic options. Here we discuss a novel therapeutic strategy to target CARM1-expressing ovar
Externí odkaz:
https://doaj.org/article/45cebc2b50b84762a2889e06d43fd8c9
Autor:
Takeshi Fukumoto, Pyoung Hwa Park, Shuai Wu, Nail Fatkhutdinov, Sergey Karakashev, Timothy Nacarelli, Andrew V. Kossenkov, David W. Speicher, Stephanie Jean, Lin Zhang, Tian-Li Wang, Ie-Ming Shih, Jose R. Conejo-Garcia, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3393-3400 (2018)
Summary: ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show tha
Externí odkaz:
https://doaj.org/article/c03c4b3064504442808ca962aa2f53e5
Autor:
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tum
Externí odkaz:
https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc
Autor:
Sergey Karakashev, Hengrui Zhu, Yuhki Yokoyama, Bo Zhao, Nail Fatkhutdinov, Andrew V. Kossenkov, Andrew J. Wilson, Fiona Simpkins, David Speicher, Dineo Khabele, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3398-3405 (2017)
Summary: PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain inhibition with PARP inhibition in BRCA-pr
Externí odkaz:
https://doaj.org/article/8f781436fa4e4979a645ce5bfdc70225
Autor:
Heng Liu, Jianhuang Lin, Wei Zhou, Renyta Moses, Zhongping Dai, Andrew V. Kossenkov, Ronny Drapkin, Benjamin G. Bitler, Sergey Karakashev, Rugang Zhang
Publikováno v:
Cancer Immunol Res
The extent to which effector CD8+ T cells infiltrate into tumors is one of the major predictors of clinical outcome for patients with epithelial ovarian cancer (EOC). Immune cell infiltration into EOC is a complex process that could be affected by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33a53980b2592b29d45ecd21131f8a4
https://doi.org/10.1158/2326-6066.cir-22-0088
https://doi.org/10.1158/2326-6066.cir-22-0088
Autor:
Rugang Zhang, Sergey Karakashev, Benjamin G. Bitler, Ronny Drapkin, Andrew V. Kossenkov, Zhongping Dai, Renyta Moses, Wei Zhou, Jianhuang Lin, Heng Liu
The extent to which effector CD8+ T cells infiltrate into tumors is one of the major predictors of clinical outcome for patients with epithelial ovarian cancer (EOC). Immune cell infiltration into EOC is a complex process that could be affected by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395b01a0437d0e20973215bab573d815
https://doi.org/10.1158/2326-6066.c.6550997
https://doi.org/10.1158/2326-6066.c.6550997
Autor:
Rugang Zhang, Sergey Karakashev, Benjamin G. Bitler, Ronny Drapkin, Andrew V. Kossenkov, Zhongping Dai, Renyta Moses, Wei Zhou, Jianhuang Lin, Heng Liu
Supplementary Figure from KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bc183288abd63c7ec094186683808f
https://doi.org/10.1158/2326-6066.22545665
https://doi.org/10.1158/2326-6066.22545665
Autor:
Rugang Zhang, Sergey Karakashev, Benjamin G. Bitler, Ronny Drapkin, Andrew V. Kossenkov, Zhongping Dai, Renyta Moses, Wei Zhou, Jianhuang Lin, Heng Liu
Supplementary Table from KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05689365577038cd98755e315b7ad342
https://doi.org/10.1158/2326-6066.22545659
https://doi.org/10.1158/2326-6066.22545659
Autor:
Rugang Zhang, Dmitry I. Gabrilovich, Qin Liu, Shuai Wu, Sergey Karakashev, Timothy Nacarelli, Evgenii N. Tcyganov, Joseph A. Zundell, Nail Fatkhutdinov, Takeshi Fukumoto
Figure S3 shows that the effects of HDAC6 inhibitor ACY1215 alone or in combination with anti-PD-L1 on tumor immune microenvironment and that the combination of HDAC6 inhibitor ACY1215 and anti-PD-L1 does not affect the body weight of the treated mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9652be67f36730a749a76e24b73b04ee
https://doi.org/10.1158/0008-5472.22426249
https://doi.org/10.1158/0008-5472.22426249