The synthesis of thioglucosides substituted 1,4-naphthoquinones and their conversion in oxathiane fused quinone-thioglucoside conjugates

Autor: Yuri E. Sabutskii, Vladimir A. Denisenko, Roman S. Popov, Sergey G. Polonik

Publikováno v: ARKIVOC, Vol 2017, Iss 3, Pp 302-315 (2017)

Externí odkaz: https://doaj.org/article/ff9d4234d55d49fb9828e37e6baf0c01

Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer

Autor: Sergey A. Dyshlovoy, Dmitry N. Pelageev, Jessica Hauschild, Yurii E. Sabutskii, Ekaterina A. Khmelevskaya, Christoph Krisp, Moritz Kaune, Simone Venz, Ksenia L. Borisova, Tobias Busenbender, Vladimir A. Denisenko, Hartmut Schlüter, Carsten Bokemeyer, Markus Graefen, Sergey G. Polonik, Victor Ph. Anufriev, Gunhild von Amsberg

Publikováno v: Marine Drugs, Vol 18, Iss 5, p 251 (2020)

The phenomenon of high sugar consumption by tumor cells is known as Warburg effect. It results from a high glycolysis rate, used by tumors as preferred metabolic pathway even in aerobic conditions. Targeting the Warburg effect to specifically deliver

Externí odkaz: https://doaj.org/article/171eebda0cf448cc81b3cc2c80b450ab

Preparative Monomethylation of 2,3,5,6,7,8-Hexahydroxynaphthalene-1,4-dione (Spinochrome E). The First Direct Synthesis of Namakochrome: the Natural Pigment of the Holothurian Polycheira rufescens

Autor: Sergey G. Polonik, Vladimir A. Denisenko, A. A. Artjukov, Yurii E Sabutskii, Roman S. Popov

Publikováno v: Russian Journal of Organic Chemistry. 56:207-212

A 4-step preparative conversion of the available sea urchins pigment spinochrome E into the holothurian Polycheira rufescens pigment namakochrome was developed. Spinochrome E was converted into hexaacetate, and one β-acetate group in the quinone cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc222c41358131a301d183b077c7f04c
https://doi.org/10.1134/s1070428020020050

Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

Autor: Viktor G Kartsev, Sergey G. Polonik, Elena Y. Komarova, Boris A. Margulis, Elizaveta Leonova, Dmitry G. Alexeev, Alina D. Nikotina, Sergey M. Efremov, Snezhana A Vladimirova, Irina V. Guzhova, Rostislav V. Pavlov

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6902
International Journal of Molecular Sciences, Vol 22, Iss 6902, p 6902 (2021)
International Journal of Molecular Sciences

Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47980f1922b9b93d09ac680568b49d7

Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones

Autor: Sergey G. Polonik, Vladimir A. Denisenko, Yuri Sabutski, Dmitry L. Aminin, Artur R. Chingizov, Roman S. Popov, L. S. Shevchenko, Valery V. Mikhailov, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova

Publikováno v: Molecules
Volume 25
Issue 16
Molecules, Vol 25, Iss 3577, p 3577 (2020)

A series of new tetracyclic oxathiine-fused quinone-thioglycoside conjugates based on biologically active 1,4-naphthoquinones and 1-mercapto derivatives of per-O-acetyl d-glucose, d-galactose, d-xylose, and l-arabinose have been synthesized, characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d47505d27c30571ade8dfd88a79eec