Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Sergey Deyev"'
Autor:
Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev, Anzhelika Vorobyeva
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Background Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPin
Externí odkaz:
https://doaj.org/article/1cdec13355ae4c87aaae315f15791931
Publikováno v:
Molecules, Vol 26, Iss 22, p 6785 (2021)
Barnase is an extracellular ribonuclease secreted by Bacillus amyloliquefaciens that was originally studied as a small stable enzyme with robust folding. The identification of barnase intracellular inhibitor barstar led to the discovery of an incredi
Externí odkaz:
https://doaj.org/article/1e22c4ccfb084fbea663ee1b8ad81500
Autor:
Yury Kostyukevich, Aleksej A. Shulga, Alexey Kononikhin, Igor Popov, Eugene Nikolaev, Sergey Deyev
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The barnase-barstar complex is one of the most stable protein-protein complexes and has a very wide range of possible applications. Here we report the use of top-down mass spectrometry for the investigation of the structure of this complex,
Externí odkaz:
https://doaj.org/article/77f8348d5f064225bbb7d7bad1a76ed0
Autor:
Anzhelika Vorobyeva, Ekaterina Bezverkhniaia, Elena Konovalova, Alexey Schulga, Javad Garousi, Olga Vorontsova, Ayman Abouzayed, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Publikováno v:
Molecules, Vol 25, Iss 20, p 4719 (2020)
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic targ
Externí odkaz:
https://doaj.org/article/c156c6384f714624808c4eba38498ace
Autor:
Maxim Sorokin, Irina Kholodenko, Daniel Kalinovsky, Tatyana Shamanskaya, Igor Doronin, Dmitry Konovalov, Aleksei Mironov, Denis Kuzmin, Daniil Nikitin, Sergey Deyev, Anton Buzdin, Roman Kholodenko
Publikováno v:
Biomedicines, Vol 8, Iss 6, p 142 (2020)
The tumor-associated ganglioside GD2 represents an attractive target for cancer immunotherapy. GD2-positive tumors are more responsive to such targeted therapy, and new methods are needed for the screening of GD2 molecular tumor phenotypes. In this w
Externí odkaz:
https://doaj.org/article/f3c8283c0f534e1091453307ac5af52a
Autor:
Elena Popova-Kuznetsova, Gleb Tikhonowski, Anton A. Popov, Vladimir Duflot, Sergey Deyev, Sergey Klimentov, Irina Zavestovskaya, Paras N. Prasad, Andrei V. Kabashin
Publikováno v:
Nanomaterials, Vol 10, Iss 1, p 69 (2019)
Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the
Externí odkaz:
https://doaj.org/article/0da863a5b805499fb46b9ed259394aeb
Autor:
Evgeniya Sokolova, Olga Kutova, Alena Grishina, Anton Pospelov, Evgeniy Guryev, Alexey Schulga, Sergey Deyev, Irina Balalaeva
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 219 (2019)
The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecul
Externí odkaz:
https://doaj.org/article/d416f8f8dfb844b188e4efa82c365b8d
Autor:
Tolmachev, Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Sophia Hober, Sergey Deyev, Jens Sörensen, Vladimir
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3149
Previous Phase I clinical evaluations of the radiolabelled scaffold proteins [99mTc]Tc-ADAPT6 and DARPin [99mTc]Tc-(HE)3-G3 in breast cancer patients have demonstrated their safety and indicated their capability to discriminate between HER2-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5ada202882f2e7c5fd56faf546a66054
Autor:
Evgeny S. Vavaev, Marina Novoselova, Nikita M. Shchelkunov, Sergei German, Aleksei S. Komlev, Maksim D. Mokrousov, Ivan V. Zelepukin, Andrey M. Burov, Boris N. Khlebtsov, Evgeny V. Lyubin, Sergey Deyev, Andrey A. Fedyanin, Dmitry A. Gorin
Publikováno v:
ACS Applied Nano Materials. 5:2994-3006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a87fc93254331c7ca1fc40e90be076
https://doi.org/10.1021/acsanm.2c00338
https://doi.org/10.1021/acsanm.2c00338
Autor:
Vorobyeva, Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Deyev, Elena Konovalova, Alexey Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15181
Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This method can also enable monitoring of the response to such therapies, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ed17c79fb261451ce7190e457bd1bada