Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sergey A. Yakimov"'
Autor:
Nikita A. Orlov, Elena V. Kryukova, Anastasia V. Efremenko, Sergey A. Yakimov, Victoria A. Toporova, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov
Publikováno v:
Membranes, Vol 13, Iss 7, p 645 (2023)
The voltage-gated potassium channel Kv1.1, which is abundant in the CNS and peripheral nervous system, controls neuronal excitability and neuromuscular transmission and mediates a number of physiological functions in non-excitable cells. The developm
Externí odkaz:
https://doaj.org/article/cfb44605bfc640008fec3610b2320174
Autor:
Alexandra L. Primak, Nikita A. Orlov, Steve Peigneur, Jan Tytgat, Anastasia A. Ignatova, Kristina R. Denisova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov
Publikováno v:
Toxins, Vol 15, Iss 3, p 229 (2023)
The growing interest in potassium channels as pharmacological targets has stimulated the development of their fluorescent ligands (including genetically encoded peptide toxins fused with fluorescent proteins) for analytical and imaging applications.
Externí odkaz:
https://doaj.org/article/98a6a2fd89be41559e83da7da2cff6be
Autor:
Nikita A. Orlov, Anastasia A. Ignatova, Elena V. Kryukova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov
Publikováno v:
Toxins, Vol 14, Iss 12, p 858 (2022)
The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases. Pore blockers of the Kv1.3 channel are consider
Externí odkaz:
https://doaj.org/article/2905dd7e5aa7467a9870eac99fe0995e
Autor:
Kristina R. Denisova, Nikita A. Orlov, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova
Publikováno v:
Bioengineering, Vol 9, Iss 7, p 295 (2022)
Fluorescently labeled peptide blockers of ion channels are useful probes in studying the localization and functioning of the channels and in the performance of a search for new channel ligands with bioengineering screening systems. Here, we report on
Externí odkaz:
https://doaj.org/article/fe12d2e85cd942369de5dcec0d938c27
GFP–Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers
Autor:
Kristina R. Denisova, Nikita A. Orlov, Sergey A. Yakimov, Elena A. Kryukova, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1724 (2022)
Peptide pore blockers and their fluorescent derivatives are useful molecular probes to study the structure and functions of the voltage-gated potassium Kv1.3 channel, which is considered as a pharmacological target in the treatment of autoimmune and
Externí odkaz:
https://doaj.org/article/d4dbe515d42645eabc0ed9e54453a53f
Autor:
Oksana V. Nekrasova, Alexandra L. Primak, Anastasia A. Ignatova, Valery N. Novoseletsky, Olga V. Geras’kina, Ksenia S. Kudryashova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexander S. Arseniev, Alexey V. Feofanov
Publikováno v:
Toxins, Vol 12, Iss 12, p 802 (2020)
Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci
Externí odkaz:
https://doaj.org/article/6c6e8f2d8c2143f7a9303d4be758b138
Autor:
Yurii Semenovich Vinnik, Olga Valerievna Teplyakova, Olga Vladimirovna Peryanova, Sergey Vladimirovich Yakimov, Anna Dmitrievna Erguleeva, Darya Nikolaevna Ponedelnik
Publikováno v:
Journal of Experimental and Clinical Surgery. 15:290-299
Introduction. Search for new means and methods of sanitation of the abdominal cavity remains significant related to growing antibiotic resistance of bacterial pathogens in surgical infection. This challenge is of particular relevance in the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0257bef085cd76306481ff8cf073b19
https://doi.org/10.18499/2070-478x-2022-15-4-290-299
https://doi.org/10.18499/2070-478x-2022-15-4-290-299
Autor:
Feofanov, Nikita A. Orlov, Elena V. Kryukova, Anastasia V. Efremenko, Sergey A. Yakimov, Victoria A. Toporova, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V.
Publikováno v:
Membranes; Volume 13; Issue 7; Pages: 645
The voltage-gated potassium channel Kv1.1, which is abundant in the CNS and peripheral nervous system, controls neuronal excitability and neuromuscular transmission and mediates a number of physiological functions in non-excitable cells. The developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f7af9e91514f45bcbc9c3a357a91ec51
Autor:
Sergey P. Yakimov
Publikováno v:
Открытое образование (Москва), Vol 0, Iss 4(99), Pp 63-69 (2016)
This article describes functional model of education by the instrumentality of IDEF0. The implementations of the proposed model for the primitive communal stage of development. The analysis of the main components of the educational process, typical o
Externí odkaz:
https://doaj.org/article/f6862116c9934f519e4bd36def5156b8
Publikováno v:
Day 4 Fri, October 15, 2021.
Today, strategic planning of field development is based on full-field static and flow simulation models which are regularly updated as part of field surveillance programs and by integrating the actual results of drilling and testing of new production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e6267b005cb03fe3c7fdf6d2faaa70
https://doi.org/10.2118/206583-ms
https://doi.org/10.2118/206583-ms