Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Sergey A. Vishnivetskiy"'
Autor:
Sergey A. Vishnivetskiy, Liana D. Weinstein, Chen Zheng, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8903 (2023)
Arrestin-1, or visual arrestin, exhibits an exquisite selectivity for light-activated phosphorylated rhodopsin (P-Rh*) over its other functional forms. That selectivity is believed to be mediated by two well-established structural elements in the arr
Externí odkaz:
https://doaj.org/article/845e7de822df4db28bffc77e69a19cf5
Autor:
Sergey A. Vishnivetskiy, Elizabeth K. Huh, Preethi C. Karnam, Samantha Oviedo, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13887 (2022)
Arrestins preferentially bind active phosphorylated G protein-coupled receptors (GPCRs). The middle loop, highly conserved in all arrestin subtypes, is localized in the central crest on the GPCR-binding side. Upon receptor binding, it directly intera
Externí odkaz:
https://doaj.org/article/bd79a96ca40a4952b91ac67c2dbe8ce3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12481 (2021)
Arrestins are a small family of proteins that bind G protein-coupled receptors (GPCRs). Arrestin binds to active phosphorylated GPCRs with higher affinity than to all other functional forms of the receptor, including inactive phosphorylated and activ
Externí odkaz:
https://doaj.org/article/3fcb56961cc14d2caef5ef0ab99655b7
Autor:
Qiuyan Chen, Nicole A. Perry, Sergey A. Vishnivetskiy, Sandra Berndt, Nathaniel C. Gilbert, Ya Zhuo, Prashant K. Singh, Jonas Tholen, Melanie D. Ohi, Eugenia V. Gurevich, Chad A. Brautigam, Candice S. Klug, Vsevolod V. Gurevich, T. M. Iverson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
While arrestins are mainly associated with GPCR signaling, arrestin-3 can signal independently of receptor interaction. Here the authors present the structure of arrestin-3 bound to inositol hexakisphosphate (IP6) and propose a model for arrestin-3 a
Externí odkaz:
https://doaj.org/article/5669fd07492147f39e3967f45e7f0f53
Autor:
Srimal Samaranayake, Xiufeng Song, Sergey A. Vishnivetskiy, Jeannie Chen, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
We determined the effects of different expression levels of arrestin-1-3A mutant with enhanced binding to light-activated rhodopsin that is independent of phosphorylation. To this end, transgenic mice that express mutant rhodopsin with zero, one, or
Externí odkaz:
https://doaj.org/article/836f3cb066a44190a2a22baa5dfb1828
Publikováno v:
J Neurochem
The finger loop in the central crest of the receptor-binding side of arrestins engages the cavity between the transmembrane helices of activated G protein-coupled receptors. Therefore, it was hypothesized to serve as the sensor that detects the activ
Publikováno v:
J Biol Chem
The multifaceted adaptor protein β-arr1 (β-arrestin1) promotes activation of focal adhesion kinase (FAK) by the chemokine receptor CXCR4, facilitating chemotaxis. This function of β-arr1 requires the assistance of the adaptor protein STAM1 (signal
Autor:
Nicole A. Perry-Hauser, Jesse B. Hopkins, Ya Zhuo, Chen Zheng, Ivette Perez, Kathryn M. Schultz, Sergey A. Vishnivetskiy, Ali I. Kaya, Pankaj Sharma, Kevin N. Dalby, Ka Young Chung, Candice S. Klug, Vsevolod V. Gurevich, T.M. Iverson
Publikováno v:
J Mol Biol
Arrestin binding to active phosphorylated G protein-coupled receptors terminates G protein coupling and initiates another wave of signaling. Among the effectors that bind directly to receptor-associated arrestins are extracellular signal-regulated ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d6e6fea5169c3a4649d48c021fddf3
https://europepmc.org/articles/PMC8977243/
https://europepmc.org/articles/PMC8977243/
Autor:
Daniel Huster, Anika Gloge, Anette Kaiser, Clemens Glaubitz, Frank Bernhard, Ulrike Krug, Vsevolod V. Gurevich, Marcel Gauglitz, Johanna Becker-Baldus, Cindy Montag, Sergey A. Vishnivetskiy, Annette G. Beck-Sickinger, Peter Schmidt
Publikováno v:
Angewandte Chemie. 132:24062-24070
Autor:
Clemens Glaubitz, Frank Bernhard, Cindy Montag, Johanna Becker-Baldus, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Ulrike Krug, Peter Schmidt, Marcel Gauglitz, Daniel Huster, Anette Kaiser, Annette G. Beck-Sickinger, Anika Gloge
Publikováno v:
Angewandte Chemie (International Ed. in English)
Dynamic structural transitions within the seven‐transmembrane bundle represent the mechanism by which G‐protein‐coupled receptors convert an extracellular chemical signal into an intracellular biological function. Here, the conformational dynam