Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sergey A. Sinenko"'
Autor:
Sergey A. Sinenko, Alexey N. Tomilin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Pluripotent stem cells of the mammalian epiblast and their cultured counterparts—embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs)—have the capacity to differentiate in all cell types of adult organisms. An artificial process of reacti
Externí odkaz:
https://doaj.org/article/6c55aab0d1804648838e1ce476f6fd8f
Autor:
Sergey A. Sinenko, Andrey A. Kuzmin, Elena V. Skvortsova, Sergey V. Ponomartsev, Evgeniya V. Efimova, Michael Bader, Natalia Alenina, Alexey N. Tomilin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4862 (2023)
The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in mammals. In this study, we set out to investigate whether and how endogenous serotonin affects
Externí odkaz:
https://doaj.org/article/2155db7bd6a245439ae46e6bba42ecc0
Autor:
Andrey A. Kuzmin, Veronika V. Ermakova, Sergey A. Sinenko, Sergey V. Ponomartsev, Tatiana Y. Starkova, Elena V. Skvortsova, Olga Cherepanova, Alexey N. Tomilin
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2019)
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or inducible variants of these recombinases are expressed under the control of e
Externí odkaz:
https://doaj.org/article/20210ca284fe45e29f0f0e8cc2e092a9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced NADPH oxidases in the cytosol. In the recent two decades, a plethora of
Externí odkaz:
https://doaj.org/article/c0c9a732321443b3bb45c82937552dbb
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10924 (2022)
Essential changes in cell metabolism and redox signaling occur during the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this paper, using genetic and pharmacological approaches, we have investigated the role of electr
Externí odkaz:
https://doaj.org/article/b72d5886807b451485f32e019a5d946c
Autor:
Sergey V. Ponomartsev, Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Ivan N. Voropaev, Maria M. Savina, Andrey A. Kuzmin, Elena Yu. Kuzmina, Alexandra M. Kondrashkina, Vladimir Larionov, Natalay Kouprina, Alexey N. Tomilin
Publikováno v:
Cells, Vol 9, Iss 4, p 879 (2020)
Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transge
Externí odkaz:
https://doaj.org/article/4f5e0539ddb941dbb6193eff810f3d45
Publikováno v:
Oncotarget
// Elena V. Skvortsova 1 , Sergey A. Sinenko 1, 2 and Alexey N. Tomilin 1, 3 1 Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russian Federation 2 Division of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclea
Autor:
Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Sergey V. Ponomartsev, Andrey A. Kuzmin, Aleksandr A. Khudiakov, Anna B. Malashicheva, Natalia Alenina, Vladimir Larionov, Natalay Kouprina, Alexey N. Tomilin
Publikováno v:
Cells, Vol 7, Iss 12, p 261 (2018)
AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver
Externí odkaz:
https://doaj.org/article/fe320cdbeceb4510ae59b59ce446545f
Publikováno v:
Cellular and Molecular Life Sciences. 78:1207-1220
A novel approach in gene therapy was introduced 20 years ago since artificial non-integrative chromosome-based vectors containing gene loci size inserts were engineered. To date, different human artificial chromosomes (HAC) were generated with the us
Publikováno v:
Acta naturae. 14(3)
Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs represent either truncated native chromosomes or de novo synthesized genetic constructs. The i