Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Sergey A. Kozlov"'
Autor:
Timur A. Khasanov, Ekaterina E. Maleeva, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev, Dmitry I. Osmakov
Publikováno v:
Marine Drugs, Vol 22, Iss 9, p 382 (2024)
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiet
Externí odkaz:
https://doaj.org/article/70c1b1e149da4fde8a7b928ad49e0b5f
Autor:
Dmitry I. Osmakov, Lyudmila V. Onoprienko, Aleksandr P. Kalinovskii, Sergey G. Koshelev, Vasiliy N. Stepanenko, Yaroslav A. Andreev, Sergey A. Kozlov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1413 (2024)
Tafalgin (Taf) is a tetrapeptide opioid used in clinical practice in Russia as an analgesic drug for subcutaneous administration as a solution (4 mg/mL; concentration of 9 mM). We found that the acid-sensing ion channels (ASICs) are another molecular
Externí odkaz:
https://doaj.org/article/23f362f711884a8887f22259b01696cc
Autor:
Aleksandr P. Kalinovskii, Anton P. Pushkarev, Anastasia D. Mikhailenko, Denis S. Kudryavtsev, Olga A. Belozerova, Vladimir I. Shmygarev, Oleg N. Yatskin, Yuliya V. Korolkova, Sergey A. Kozlov, Dmitry I. Osmakov, Alexander Popov, Yaroslav A. Andreev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13148 (2023)
Acid-sensing ion channels (ASICs) are proton-gated ion channels that mediate nociception in the peripheral nervous system and contribute to fear and learning in the central nervous system. Sevanol was reported previously as a naturally-occurring ASIC
Externí odkaz:
https://doaj.org/article/f1f45347b7d24bdb9c1bc4fdbb292d54
Autor:
Irina N. Gladkikh, Anna A. Klimovich, Rimma S. Kalina, Yulia V. Kozhevnikova, Timur A. Khasanov, Dmitry I. Osmakov, Sergey G. Koshelev, Margarita M. Monastyrnaya, Yaroslav A. Andreev, Elena V. Leychenko, Sergey A. Kozlov
Publikováno v:
Toxins, Vol 15, Iss 5, p 341 (2023)
Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change within both physiological and pathological conditions. ASIC-targeting peptide toxins could be potent molecular tools for ASIC-manipulating in vitro, and for pathology t
Externí odkaz:
https://doaj.org/article/fa583ba740f54b6d988f8efc0a6ff12c
Autor:
Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Irina N. Gladkikh, Aleksandra N. Kvetkina, Oksana V. Sintsova, Darya V. Popkova, Sergei A. Kozlovskiy, Tatiana Y. Gorpenchenko, Galina N. Likhatskaya, Leonid A. Kaluzhskiy, Alexis S. Ivanov, Yaroslav A. Andreev, Sergey A. Kozlov, Pavel S. Dmitrenok, Dmitry L. Aminin, Elena V. Leychenko
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 192 (2023)
Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions including neurodegeneration. Here, we investigated the impact of peptides on purinergic sign
Externí odkaz:
https://doaj.org/article/e7c43202179d45b984cb264e4abb245f
Autor:
Yanina V. Burgart, Natalia A. Elkina, Evgeny V. Shchegolkov, Olga P. Krasnykh, Galina F. Makhaeva, Galina A. Triandafilova, Sergey Yu. Solodnikov, Natalia P. Boltneva, Elena V. Rudakova, Nadezhda V. Kovaleva, Olga G. Serebryakova, Mariya V. Ulitko, Sophia S. Borisevich, Natalia A. Gerasimova, Natalia P. Evstigneeva, Sergey A. Kozlov, Yuliya V. Korolkova, Artem S. Minin, Anna V. Belousova, Evgenii S. Mozhaitsev, Artem M. Klabukov, Victor I. Saloutin
Publikováno v:
Molecules, Vol 28, Iss 1, p 59 (2022)
4-Arylhydrazinylidene-5-(polyfluoroalkyl)pyrazol-3-ones (4-AHPs) were found to be obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3-oxoesters with hydrazines, by the azo coupling of 4-nonsubstituted pyrazol-5-ol
Externí odkaz:
https://doaj.org/article/e03f60e649344091824c96142959378b
Autor:
Rimma S. Kalina, Irina N. Gladkikh, Anna A. Klimovich, Yulia V. Kozhevnikova, Aleksandra N. Kvetkina, Eugene A. Rogozhin, Sergey G. Koshelev, Sergey A. Kozlov, Elena V. Leychenko
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1705 (2022)
A novel peptide AnmTX Sco 9a-1 with the β-hairpin fold was isolated from the swimming sea anemone Stomphia coccinea (Actinostolidae family). The peptide consists of 28 amino acid residues, including modified hydroxyproline residue, and its measured
Externí odkaz:
https://doaj.org/article/1ed0feb49af9480ea3bbcd0e72c885c0
Autor:
Rimma S. Kalina, Igor E. Kasheverov, Sergey G. Koshelev, Oksana V. Sintsova, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Roman S. Popov, Victoria E. Chausova, Margarita M. Monastyrnaya, Pavel S. Dmitrenok, Marina P. Isaeva, Jan Tytgat, Sergey A. Kozlov, Emma P. Kozlovskaya, Elena V. Leychenko, Irina N. Gladkikh
Publikováno v:
Toxins, Vol 14, Iss 10, p 697 (2022)
The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters. Here, four APETx-like toxins, including tw
Externí odkaz:
https://doaj.org/article/f8c7904b69e44bd89b55f55789cdec7a
Autor:
Dmitry I. Osmakov, Aleksandr P. Kalinovskii, Olga A. Belozerova, Yaroslav A. Andreev, Sergey A. Kozlov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6031 (2022)
Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis.
Externí odkaz:
https://doaj.org/article/d75e74a2f1404b569d230e5f2e80c3ed
Autor:
Xinrui Liu, Maksim S. Kulya, Nikolay V. Petrov, Yaroslav V. Grachev, Mingzhao Song, Anton N. Tcypkin, Sergey A. Kozlov, Xi-Cheng Zhang
Publikováno v:
AIP Advances, Vol 10, Iss 12, Pp 125104-125104-7 (2020)
We proposed a simple and cost-effective method to manipulate the temporal and spectral properties of pulsed terahertz waves. A deep modulation of a pulse spectrum was both numerically and experimentally verified using Fresnel apertures with a radius
Externí odkaz:
https://doaj.org/article/fc67e17ab2eb4d70ae4bec40e04a6a0c