Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Sergey A. Kochetkov"'
Derivatives of Pyrimidine Nucleosides Affect Artificial Membranes Enriched with Mycobacterial Lipids
Autor:
Olga S. Ostroumova, Svetlana S. Efimova, Polina D. Zlodeeva, Liudmila A. Alexandrova, Dmitry A. Makarov, Elena S. Matyugina, Vera A. Sokhraneva, Anastasia L. Khandazhinskaya, Sergey N. Kochetkov
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1110 (2024)
The mechanisms of action of pyrimidine nucleoside derivatives on model lipid membranes of various compositions were studied. A systematic analysis of the tested agents’ effects on the membrane physicochemical properties was performed. Differential
Externí odkaz:
https://doaj.org/article/b66b0686a2264f98ad282d3178176a2e
Autor:
Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 798 (2024)
Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant E. coli purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction. In addition to “ty
Externí odkaz:
https://doaj.org/article/6dc5ba4973204c2f85cf40e3a5e85b6f
Autor:
Olga N. Ivanova, Anna V. Gavlina, Inna L. Karpenko, Martin A. Zenov, Svetlana S. Antseva, Natalia F. Zakirova, Vladimir T. Valuev-Elliston, George S. Krasnov, Irina T. Fedyakina, Pavel O. Vorobyev, Birke Bartosch, Sergey N. Kochetkov, Anastasiya V. Lipatova, Dmitry V. Yanvarev, Alexander V. Ivanov
Publikováno v:
Cells, Vol 13, Iss 13, p 1134 (2024)
Biogenic polyamines are ubiquitous compounds. Dysregulation of their metabolism is associated with the development of various pathologies, including cancer, hyperproliferative diseases, and infections. The canonical pathway of polyamine catabolism in
Externí odkaz:
https://doaj.org/article/e2310228fff64a8eabd12fc2d6a9d26e
Autor:
Natalia F. Zakirova, Olga A. Khomich, Olga A. Smirnova, Jennifer Molle, Sarah Duponchel, Dmitry V. Yanvarev, Vladimir T. Valuev-Elliston, Lea Monnier, Boyan Grigorov, Olga N. Ivanova, Inna L. Karpenko, Mikhail V. Golikov, Cedric Bovet, Barbara Rindlisbacher, Alex R. Khomutov, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov
Publikováno v:
Cells, Vol 13, Iss 12, p 1036 (2024)
Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice. However, clearance of the virus does not
Externí odkaz:
https://doaj.org/article/4a062fcad91f4c409b2a06d43ebfde9f
Autor:
Maxim A. Khomutov, Fabio Giovannercole, Laura Onillon, Marija V. Demiankova, Byazilya F. Vasilieva, Arthur I. Salikhov, Sergey N. Kochetkov, Olga V. Efremenkova, Alex R. Khomutov, Daniela De Biase
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1451 (2023)
New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, antibiotics targeting bacterial central metabolism have been poorly investigated. By determining the minimal inhibitory concentratio
Externí odkaz:
https://doaj.org/article/e3cc8080fa684d93b2ab16ca9cd35e41
Publikováno v:
Algorithms, Vol 16, Iss 9, p 405 (2023)
Planning an achievable trajectory for a mobile robot usually consists of two steps: (i) finding a path in the form of a sequence of discrete waypoints and (ii) transforming this sequence into a continuous and smooth curve. To solve the second problem
Externí odkaz:
https://doaj.org/article/30233acb3b114a09906b3763c71b4f66
Autor:
Maxim A. Khomutov, Arthur I. Salikhov, Vladimir A. Mitkevich, Vera L. Tunitskaya, Olga A. Smirnova, Sergey P. Korolev, Alexander O. Chizhov, Marina B. Gottikh, Sergey N. Kochetkov, Alex R. Khomutov
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 916 (2023)
The biogenic polyamines, spermidine (Spd) and spermine (Spm), are present at millimolar concentrations in all eukaryotic cells, where they participate in the regulation of vitally important cellular functions. Polyamine analogs and derivatives are a
Externí odkaz:
https://doaj.org/article/83c8159615dd4817a7b904a1fbad6215
Autor:
Olga A. Smirnova, Olga N. Ivanova, Furkat Mukhtarov, Vladimir T. Valuev-Elliston, Artemy P. Fedulov, Petr M. Rubtsov, Natalia F. Zakirova, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 974 (2023)
Hepatitis delta virus (HDV) is a viroid-like satellite that may co-infect individuals together with hepatitis B virus (HBV), as well as cause superinfection by infecting patients with chronic hepatitis B (CHB). Being a defective virus, HDV requires H
Externí odkaz:
https://doaj.org/article/887122b31b1a4cab9c0bc058cbb6f98c
Autor:
Olga N. Ivanova, George S. Krasnov, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Vyacheslav S. Fedorov, Natalia F. Zakirova, Michail V. Golikov, Sergey N. Kochetkov, Birke Bartosch, Vladimir T. Valuev-Elliston, Alexander V. Ivanov
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 714 (2023)
Reactive oxygen species (ROS) play a major role in the regulation of various processes in the cell. The increase in their production is a factor contributing to the development of numerous pathologies, including inflammation, fibrosis, and cancer. Ac
Externí odkaz:
https://doaj.org/article/0adf0885a4dd4303b2dd4a7368e1dfc0
Autor:
Konstantin V. Potapov, Roman A. Novikov, Maxim A. Novikov, Pavel N. Solyev, Yury V. Tomilov, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich
Publikováno v:
Molecules, Vol 28, Iss 8, p 3568 (2023)
Bacterial cystathionine γ-lyase (bCSE) is the main producer of H2S in pathogenic bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, etc. The suppression of bCSE activity considerably enhances the sensitivity of bacteria to antibiotics.
Externí odkaz:
https://doaj.org/article/62897d7ae169496ead6c6bfef87fcff0