Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Sergey A Vishnivetskiy"'
Autor:
Jaroslawna Meister, Derek B J Bone, Grzegorz Godlewski, Ziyi Liu, Regina J Lee, Sergey A Vishnivetskiy, Vsevolod V Gurevich, Danielle Springer, George Kunos, Jürgen Wess
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008424 (2019)
Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly expand available therape
Externí odkaz:
https://doaj.org/article/f1ec279c35aa4678b666611bb8948281
Autor:
Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke
Publikováno v:
eLife, Vol 4 (2015)
Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin. Timely rhodopsin desensitization depends on phosphorylation and arrestin binding, which quenches
Externí odkaz:
https://doaj.org/article/4edccd85553d48d8a0ead6c6fbec1158
Autor:
Whitney M Cleghorn, Elviche L Tsakem, Xiufeng Song, Sergey A Vishnivetskiy, Jungwon Seo, Jeannie Chen, Eugenia V Gurevich, Vsevolod V Gurevich
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22797 (2011)
Light-induced rhodopsin signaling is turned off with sub-second kinetics by rhodopsin phosphorylation followed by arrestin-1 binding. To test the availability of the arrestin-1 pool in dark-adapted outer segment (OS) for rhodopsin shutoff, we measure
Externí odkaz:
https://doaj.org/article/ae346e33b06e448385e7213e94667fa2
Autor:
Sergey A. Vishnivetskiy, Liana D. Weinstein, Chen Zheng, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8903
Arrestin-1, or visual arrestin, exhibits an exquisite selectivity for light-activated phosphorylated rhodopsin (P-Rh*) over its other functional forms. That selectivity is believed to be mediated by two well-established structural elements in the arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520eb3a8bf5323d44a9c5f77deea8d77
Autor:
Srimal Samaranayake, Xiufeng Song, Sergey A. Vishnivetskiy, Jeannie Chen, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
We determined the effects of different expression levels of arrestin-1-3A mutant with enhanced binding to light-activated rhodopsin that is independent of phosphorylation. To this end, transgenic mice that express mutant rhodopsin with zero, one, or
Externí odkaz:
https://doaj.org/article/836f3cb066a44190a2a22baa5dfb1828
Publikováno v:
J Neurochem
The finger loop in the central crest of the receptor-binding side of arrestins engages the cavity between the transmembrane helices of activated G protein-coupled receptors. Therefore, it was hypothesized to serve as the sensor that detects the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c95600f14c62574e30fb845832fd0f4
https://doi.org/10.1111/jnc.15232
https://doi.org/10.1111/jnc.15232
Publikováno v:
J Biol Chem
The multifaceted adaptor protein β-arr1 (β-arrestin1) promotes activation of focal adhesion kinase (FAK) by the chemokine receptor CXCR4, facilitating chemotaxis. This function of β-arr1 requires the assistance of the adaptor protein STAM1 (signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ee68e60fdace82fc83cff90b49c261
https://doi.org/10.1074/jbc.ra120.015074
https://doi.org/10.1074/jbc.ra120.015074
Autor:
Daniel Huster, Anika Gloge, Anette Kaiser, Clemens Glaubitz, Frank Bernhard, Ulrike Krug, Vsevolod V. Gurevich, Marcel Gauglitz, Johanna Becker-Baldus, Cindy Montag, Sergey A. Vishnivetskiy, Annette G. Beck-Sickinger, Peter Schmidt
Publikováno v:
Angewandte Chemie. 132:24062-24070
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a612a46e5414b786fbf4c946ccdf007
https://doi.org/10.1002/ange.202006075
https://doi.org/10.1002/ange.202006075
Autor:
Clemens Glaubitz, Frank Bernhard, Cindy Montag, Johanna Becker-Baldus, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Ulrike Krug, Peter Schmidt, Marcel Gauglitz, Daniel Huster, Anette Kaiser, Annette G. Beck-Sickinger, Anika Gloge
Publikováno v:
Angewandte Chemie (International Ed. in English)
Dynamic structural transitions within the seven‐transmembrane bundle represent the mechanism by which G‐protein‐coupled receptors convert an extracellular chemical signal into an intracellular biological function. Here, the conformational dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b371621ae3f5d61af415ef50a6421e
https://doi.org/10.1002/anie.202006075
https://doi.org/10.1002/anie.202006075
Autor:
Chen Zheng, Eugenia V. Gurevich, Vsevolod V. Gurevich, Sergey A. Vishnivetskiy, Mira B. May, Preethi C. Karnam
Publikováno v:
J Neurochem
Arrestins demonstrate strong preference for phosphorylated over unphosphorylated receptors, but how arrestins “sense” receptor phosphorylation is unclear. A conserved lysine in the lariat loop of arrestins directly binds the phosphate in crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145f2aabb2eb6da267f00f60ee86919e
https://doi.org/10.1111/jnc.15110
https://doi.org/10.1111/jnc.15110