Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sergey A Sosunov"'
Autor:
Korapat Mayurasakorn, Zoya V Niatsetskaya, Sergey A Sosunov, Jill J Williams, Hylde Zirpoli, Iliyan Vlasakov, Richard J Deckelbaum, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160870 (2016)
Treatment with triglyceride emulsions of docosahexaenoic acid (tri-DHA) protected neonatal mice against hypoxia-ischemia (HI) brain injury. The mechanism of this neuroprotection remains unclear. We hypothesized that administration of tri-DHA enriches
Externí odkaz:
https://doaj.org/article/25908a8bcdaf4ecc90ae9ce63fff873f
Autor:
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120456 (2015)
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial r
Externí odkaz:
https://doaj.org/article/432e7a840dae49aea3ffffb6dae864ae
Autor:
Hylde Zirpoli, Maria Eugenia Bernis, Hemmen Sabir, Denny Joseph Manual Kollareth, James A. Hamilton, Nasi Huang, Jesse Ng, Sergey A. Sosunov, Ben Gaebler, Vadim S. Ten, Richard J. Deckelbaum
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116749- (2024)
Hypoxic-ischemic encephalopathy (HIE), resulting from a lack of blood flow and oxygen before or during newborn delivery, is a leading cause of cerebral palsy and neurological disability in children. Therapeutic hypothermia (TH), the current standard
Externí odkaz:
https://doaj.org/article/09898beb26164f4ab55eb2a4d98f52a4
Autor:
Irina V Utkina-Sosunova, Zoya V Niatsetskaya, Sergey A Sosunov, Veniamin I Ratner, Dzmitry Matsiukevich, Vadim S Ten
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62448 (2013)
Nelfinavir (NLF), an antiretroviral agent, preserves mitochondrial membranes integrity and protects mature brain against ischemic injury in rodents. Our study demonstrates that in neonatal mice NLF significantly limits mitochondrial calcium influx, t
Externí odkaz:
https://doaj.org/article/28ca643e5f904cae9f3ba282b11cc326
Autor:
Andrew F Ducruet, Brad E Zacharia, Sergey A Sosunov, Paul R Gigante, Mason L Yeh, Justin W Gorski, Marc L Otten, Richard Y Hwang, Peter A DeRosa, Zachary L Hickman, Paulina Sergot, E Sander Connolly
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38664 (2012)
The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Re
Externí odkaz:
https://doaj.org/article/86b13f22d9e74f47a810f87d721e7612
Autor:
Courtney Juliano, Zoya V. Niatsetskaya, Alexander Galkin, Veniamin Ratner, Anna A. Stepanova, Sergey A. Sosunov, Vadim S. Ten
Publikováno v:
Pediatric Research. 91:1383-1390
BACKGROUND In the developing brain, the death of immature oligodendrocytes (OLs) has been proposed to explain a developmental window for vulnerability to white matter injury (WMI). However, in neonatal mice, chronic sublethal intermittent hypoxia (IH
Autor:
Hylde Zirpoli, Denny Joseph Kollareth Manual, Sergey A Sosunov, Sundas Rashid, Jesse Ng, Nasi Huang, Jaroslav Lralovec, Korapat Mayurasakorn, James A Hamilton, Vadim S Ten, Richard J Deckelbaum
Publikováno v:
Stroke. 53
Introduction: Omega-3 (n-3) fatty acids (FAs), specifically docohexaenoic acid (DHA) and eicosapentaenoic acid (EPA), act as bioactive unsaturated lipids with pleiotropic effects, affording neuroprotection in ischemic brain injury. Hypothesis: We rep
Autor:
Sergey A, Sosunov, Zoya V, Niatsetskaya, Anna A, Stepanova, Alexander S, Galkin, Courtney E, Juliano, Veniamin I, Ratner, Vadim S, Ten
Publikováno v:
Pediatric research. 91(6)
In the developing brain, the death of immature oligodendrocytes (OLs) has been proposed to explain a developmental window for vulnerability to white matter injury (WMI). However, in neonatal mice, chronic sublethal intermittent hypoxia (IH) recapitul
Autor:
Michael P. Murphy, Alexa L. Hodges, Matthew A. Deragon, William D. McCaig, Timothy J. LaRocca, Robert J. Haluska, Vadim S. Ten, Payal S. Patel, Sergey A. Sosunov
Publikováno v:
Cell Death Discovery
We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of necroptotic proteins leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf1ad7b25d06f80ef06e067ed032b3e
https://www.repository.cam.ac.uk/handle/1810/315499
https://www.repository.cam.ac.uk/handle/1810/315499
Autor:
Maria Neginskaya, Evgeny Pavlov, Anna Stepanova, Alexander Galkin, Vadim S. Ten, Sergey A. Sosunov, Zoya V. Niatsetskaya, James E. Goldman
Publikováno v:
J Clin Invest
Postnatal failure of oligodendrocyte maturation has been proposed as a cellular mechanism of diffuse white matter injury (WMI) in premature infants. However, the molecular mechanisms for oligodendrocyte maturational failure remain unclear. In neonata