The Copper Reduction Potential Determines the Reductive Cytotoxicity: Relevance to the Design of Metal–Organic Antitumor Drugs

Autor: Elena K. Beloglazkina, Anna A. Moiseeva, Sergey A. Tsymbal, Dmitry A. Guk, Mikhail A. Kuzmin, Olga O. Krasnovskaya, Roman S. Borisov, Elena S. Barskaya, Victor A. Tafeenko, Victoria M. Alpatova, Andrei V. Zaitsev, Alexander V. Finko, Valentina A. Ol’shevskaya, Alexander A. Shtil

Publikováno v: Molecules, Vol 29, Iss 5, p 1032 (2024)

Copper–organic compounds have gained momentum as potent antitumor drug candidates largely due to their ability to generate an oxidative burst upon the transition of Cu2+ to Cu1+ triggered by the exogenous-reducing agents. We have reported the diffe

Externí odkaz: https://doaj.org/article/c0a7ef49ca3f4c05a365654eecedaf69

Multifunctional tunable ZnFe2O4@MnFe2O4 nanoparticles for dual-mode MRI and combined magnetic hyperthermia with radiotherapy treatment

Autor: Ilia D. Shabalkin, Alexey S. Komlev, Sergey A. Tsymbal, Oleg I. Burmistrov, Vladimir I. Zverev, Pavel V. Krivoshapkin

Publikováno v: Journal of Materials Chemistry B. 11:1068-1078

We have developed a new core@shell composition system ZnFe2O4@MnFe2O4 for the full cycle of cancer treatment. During the study, the effect of the influence of particles on MRI diagnostics, radiotherapy and magnetic hyperthermia was evaluated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474462ca2fd4b22233703486171bcdb8
https://doi.org/10.1039/d2tb02186b

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

Autor: Vladislav A. Vasilichin, Sergey A. Tsymbal, Anna F. Fakhardo, Elizaveta I. Anastasova, Andrey S. Marchenko, Alexander A. Shtil, Vladimir V. Vinogradov, Elena I. Koshel

Publikováno v: Nanomaterials, Vol 10, Iss 1, p 127 (2020)

For the widespread application of nanotechnology in biomedicine, it is necessary to obtain information about their safety. A critical problem is presented by the host immune responses to nanomaterials. It is assumed that the innate immune system play

Externí odkaz: https://doaj.org/article/a9f886601c184b999256d3bf12131de1

Copper-Containing Nanoparticles and Organic Complexes: Metal Reduction Triggers Rapid Cell Death via Oxidative Burst

Autor: Nikol A. Agadzhanian, Dmitry A. Guk, A. V. Zaitsev, Alexander A. Shtil, Anna Shibaeva, Svetlana S. Efimova, Elena K. Beloglazkina, Sergey A. Tsymbal, Olga S. Ostroumova, Alina A. Markova, Olga O. Krasnovskaya, Marina Dukhinova, Valentina A. Ol'shevskaya, Anna A. Moiseeva, Victoria M. Alpatova, Victor V. Tatarskiy

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11065, p 11065 (2021)
Volume 22
Issue 20

Copper-containing agents are promising antitumor pharmaceuticals due to the ability of the metal ion to react with biomolecules. In the current study, we demonstrate that inorganic Cu2+ in the form of oxide nanoparticles (NPs) or salts, as well as Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5deb42b750000dc9bc85be22f923929
https://pubmed.ncbi.nlm.nih.gov/34681725

Metal-derived nanoparticles in tumor theranostics: Potential and limitations

Autor: M.V. Shestovskaya, Marina Dukhinova, Sergey A. Tsymbal, O.A. Kuchur, Nikita S. Serov, Alexander A. Shtil

Publikováno v: Journal of Inorganic Biochemistry. 209:111117

Initially, metal derived nanoparticles have been used exclusively as contrasting agents in magnetic resonance imaging. Today, green routes of chemical synthesis together with numerous modifications of the core and surface gave rise to a plethora of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254e2ce775d6b42534006e30d947f075
https://doi.org/10.1016/j.jinorgbio.2020.111117