Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sergej L. Mironov"'
Autor:
Saju Balakrishnan, Sergej L. Mironov
Publikováno v:
Current Research in Physiology, Vol 3, Iss , Pp 20-29 (2020)
Ammonia (NH4+) is a by-product of cell metabolism and may elicit subcellular effects with specific physiological responses. Chronic effects have been implicated in several neurological diseases and attributed to persistent elevation in blood ammonia
Externí odkaz:
https://doaj.org/article/4916b8c22c5648949948f461e8db7a6c
Autor:
Saju Balakrishnan, Sergej L. Mironov
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Rett syndrome (RTT) is a neurological disorder caused by the mutation of the X-linked MECP2 gene. The neurophysiological hallmark of the RTT phenotype is the hyperexcitability of neurons made responsible for frequent epileptic attacks in the patients
Externí odkaz:
https://doaj.org/article/f0294c156d02469c92a52fd437c8738a
Autor:
Sergej L, Mironov
Publikováno v:
The Journal of physiology. 593(1)
In Parkinson's disease, the protein α-synuclein (αS) is produced within neurons and also appears in the extracellular fluid. In this study in hippocampal neurons, αS formed non-selective cation channels with multiple levels of conductance and rect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a4e0e710c3f1134c61ad4652fbd0bd1
https://pubmed.ncbi.nlm.nih.gov/25556793
https://pubmed.ncbi.nlm.nih.gov/25556793
Publikováno v:
Journal of neurochemistry. 117(2)
The exchange factor directly activated by cAMP (Epac) can couple cAMP production to the activation of particular membrane and cytoplasmic targets. Using patch-clamp recordings and calcium imaging in organotypic brainstem slices, we examined the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83144cf6c00b2d8426d3693761505e30
https://pubmed.ncbi.nlm.nih.gov/21281309
https://pubmed.ncbi.nlm.nih.gov/21281309
Autor:
Sergej L. Mironov
Publikováno v:
Journal of Theoretical Biology. 146:87-97
A mathematical model is described that accounts propagating waves of free cytoplasmic Ca arising from the activation of single Ca release channels. The [Ca] wave moves along the surface of intracellular stores and is supported by the subsequent activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9127ae859069d5961374915e06f1762a
https://doi.org/10.1016/s0022-5193(05)80045-1
https://doi.org/10.1016/s0022-5193(05)80045-1
Autor:
Sergej L. Mironov, M.Usachev Juri
Publikováno v:
Neuroscience Letters. 112:184-189
The fluorescent Ca-sensitive probe fura-2 was used in isolated non-identified neurons of the snail, Helix pomatia, to study the recovery from Sr and Ba loading and the effect of these cations on Ca-induced Ca release. Sr was shown to behave similarly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1030fcf347c8d8eb5f6c8c1bb586050
https://doi.org/10.1016/0304-3940(90)90200-s
https://doi.org/10.1016/0304-3940(90)90200-s
Publikováno v:
The Journal of biological chemistry. 280(1)
The positioning and dynamics of organelles depend on membrane-cytoskeleton interactions. Mitochondria relocate along microtubules (MT), but it is not clear whether MT have direct effects on mitochondrial function. Using two-photon microscopy and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ec429733a0063bf770bc754825d2fd2
https://pubmed.ncbi.nlm.nih.gov/15516333
https://pubmed.ncbi.nlm.nih.gov/15516333
Autor:
Sergej L. Mironov, Anton Hermann
Publikováno v:
Brain research. 714(1-2)
The effects of ethanol on intracellular free Ca(2+) concentration, [Ca](i), were studied in cultured rat hippocampal neurons using fluo-3 and confocal microscopy. Ethanol application transiently elevAted [Ca](i) due to Ca(2+)-induced Ca(2+) release f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6283fe894dcc905e9f278d1ea7763eca
https://pubmed.ncbi.nlm.nih.gov/8861606
https://pubmed.ncbi.nlm.nih.gov/8861606
Autor:
Saju Balakrishnan, Sergej L Mironov
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195094 (2018)
Hyperventilation is a known feature of Rett syndrome (RTT). However, how hyperventilation is related to other RTT symptoms such as hyperexcitability is unknown. Intense breathing during hyperventilation induces hypocapnia and culminates in respirator
Externí odkaz:
https://doaj.org/article/54a53ee4c51d4bd19e66126380c5f4a8
Autor:
Saju Balakrishnan, Sergej L Mironov
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202802 (2018)
Excess glutamate during intense neuronal activity is not instantly cleared and may accumulate in the extracellular space. This has various long-term consequences such as ectopic signaling, modulation of synaptic efficacy and excitotoxicity; the latte
Externí odkaz:
https://doaj.org/article/1d09ef89e9eb41dd831fc0f70e1c71ee