Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sergej Šesták"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 282-293 (2023)
A synthesis of 1,4-imino-ᴅ-lyxitols and their N-arylalkyl derivatives altered at C-5 is reported. Their inhibitory activity and selectivity toward four GH38 α-mannosidases (two Golgi types: GMIIb from Drosophila melanogaster and AMAN-2 from Caenor
Externí odkaz:
https://doaj.org/article/82908c4ffdea4294b3fd64371df93220
Autor:
Rebeka Kodríková, Zuzana Pakanová, Maroš Krchňák, Mária Šedivá, Sergej Šesták, Filip Květoň, Gábor Beke, Anna Šalingová, Katarína Skalická, Katarína Brennerová, Emília Jančová, Peter Baráth, Ján Mucha, Marek Nemčovič
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 580 (2023)
Congenital disorders of glycosylation (CDG) are a group of rare inherited metabolic disorders caused by a defect in the process of protein glycosylation. In this work, we present a comprehensive glycoprofile analysis of a male patient with a novel mi
Externí odkaz:
https://doaj.org/article/b8f285849fce43669acafaebbecacf11
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2156-2162 (2018)
A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines. An impact of the C-5 modificati
Externí odkaz:
https://doaj.org/article/40bf1218cf6c44b2a1f2b14752387ecb
Publikováno v:
Organic & Biomolecular Chemistry. 20:8932-8943
A binding mechanism of selective inhibitors of Golgi α-mannosidase II was elucidated by pKa and FMO-PIEDA calculations. Synthetic N-substituted imino-d-lyxitol inhibitors were evaluated with four enzymes from the glycoside hydrolase GH38 family.
Publikováno v:
New Journal of Chemistry. 45:10940-10951
N-Alkylated 1,4-dideoxy-1,4-imino-L-lyxitols (N-alkylated polyhydroxypyrrolidines) differing in the alkyl chain length (from C7 to C14) and their capping functional group (methyl, amine, amidine and guanidine) have been synthesized. Based on molecula
Autor:
Carmen Talotta, Francesca Cardona, Placido Neri, Sergej Šesták, Carmine Gaeta, Andrea Goti, Camilla Matassini, Paolo Della Sala, Costanza Vanni, Luca Di Marino
Publikováno v:
Organic Chemistry Frontiers. 8:6648-6656
The synthesis of multivalent ligands able to selectively bind enzymes has produced a multitude of new glycomimetics anchored to different macrocyclic scaffolds. However, in this scenario, the studies focused on therapeutically relevant enzymes are st
Autor:
Ján Moncoľ, Sergej Šesták, Miroslav Koóš, Juraj Kóňa, Mária Zajičková, Maroš Bella, Martin Kalník
Publikováno v:
New Journal of Chemistry. 45:13539-13548
A synthetic approach to hydroxymethyl analogues of mannostatin A starting from L-ribose is described. The key step employed in the synthesis of homomannostatin A was ring-opening of aziridine intermediates with sodium methanethiolate in DMF. Regiosel
Publikováno v:
ChemistrySelect. 5:4967-4972
Autor:
Alexandra Mc Cullough, Zuzana Pakanová, Anna Hlavatá, A. Salingova, Barbara Siváková, Claudia Šebová, Jan Mucha, Marek Nemčovič, Peter Barath, Ingrid Brucknerová, Vladimir Bzduch, Dimitra-Evanthia Lekka, Jana Ziburová, Martina Skokňová, Sergej Šesták, Jana Bellová, Jana Brucknerová, Mária Ostrožlíková, Gabriela Hrčková
Publikováno v:
American journal of medical genetics. Part A. 185(11)
Congenital disorder of glycosylation type Ig (ALG12-CDG) is a rare inherited metabolic disease caused by a defect in alpha-mannosyltransferase 8, encoded by the ALG12 gene (22q13.33). To date, only 15 patients have been diagnosed with ALG12-CDG globa
Publikováno v:
Bioorganic Chemistry. 83:424-431
Inhibition of the biosynthesis of complex N-glycans in the Golgi apparatus is one of alternative ways to suppress growth of tumor tissue. Eight N-benzyl substituted 1,4-imino- l -lyxitols with basic functional groups (amine, amidine, guanidine), hydr