Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sergei Zaytsev"'
Autor:
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Externí odkaz:
https://doaj.org/article/5b46ccfab9ca479b9559e7eb89df9a94
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
Background Recombinant activated protein C is protective in animal models of sepsis, stroke, and focal thrombosis, but has a poor side effect profile. Thrombomodulin (TM) and the Endothelial Protein C Receptor (EPCR) are endothelial membrane proteins
Autor:
Jingyan Han, Charles T. Esmon, Bi-Sen Ding, Ronald Carnemolla, Vladimir R. Muzykantov, Colin F. Greineder, Elizabeth D. Hood, Ann-Marie Chacko, Blaine J. Zern, Sergei Zaytsev
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
PLoS ONE
PLoS ONE
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Autor:
Rudy Fuentes, Douglas B. Cines, Sergei Zaytsev, Vladimir R. Muzykantov, Mortimer Poncz, Vincent Hayes, Hyun Sook Ahn
Publikováno v:
Blood. 124:579-579
Two major clinical limitations to the use of thrombolytic agents are their short half-life and lack of targeting specificity. We aimed to circumvent these limitations by targeting a platelet-bound, thrombin-activatable, low molecular weight urokinase
Publikováno v:
Blood. 120:3351-3351
Abstract 3351 The thrombomodulin-protein C pathway has important antithrombotic and anti-inflammatory roles in a variety of disease models and human illnesses, including severe sepsis, acute lung injury, and focal ischemia & reperfusion. We recently
Autor:
Valerie Tutwiler, John W. Weisel, Vincent Hayes, Douglas B. Cines, Mortimer Poncz, Lubica Rauova, Hyun Sook Ahn, X. Long Zheng, Steven E. McKenzie, Rudy Fuentes, Sergei Zaytsev
Publikováno v:
Blood. 120:635-635
Abstract 635 HIT is an immune mediated prothrombotic disorder often associated with life- and limb-threatening thrombosis caused by antibodies to a complex between platelet factor 4 (PF4) and heparin. Platelet activation and clearance are considered