Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sergei Zari"'
Autor:
Sergei Zari, Juliano Ndoj, Jolanta Grembecka, Paula González-Alonso, Katarzyna Kempińska, Mykhaylo A. Potopnyk, Tomasz Cierpicki, Hongzhi Miao, Caroline Nikolaidis, Andrew D. Henderson, Huang Huang, Trupta Purohit, David S. Rogawski, Shirish Shukla, Christina A. Howard, Adolfo A. Ferrando, Hyo Je Cho, Joshua Abbott, Anna K. Mapp, Maria Luisa Sulis, Hao Li
Publikováno v:
Nature Chemical Biology. 16:1403-1410
The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their
Publikováno v:
ChemInform. 46
A Schiff base isatin derivative serves as the substrate for the title reaction with unsaturated 1,4-diketones and depending on the diketone substituents the products are obtained with high to excellent yields and moderate to high enantioselectivities
Autor:
Sergei Zari, Mario Oeeren, Margus Lopp, Tõnis Kanger, Ivar Jaerving, Maksim Ošeka, Artur Noole
Publikováno v:
ChemInform. 46
The title reaction is based on the Michael addition of 3-chlorooxindole (I) to unsaturated 1,4-dicarbonyl compounds (II) and (IV), followed by an intramolecular nucleophilic substitution.
Publikováno v:
ChemInform. 45
Michael addition of the isatin imine (I) to aliphatic 1,4-ketoesters requires a much longer reaction time than the one to aromatic 1,4-ketoesters.
Autor:
Sergei Žari, Tiiu Kailas, Marina Kudrjashova, Mario Öeren, Ivar Järving, Toomas Tamm, Margus Lopp, Tõnis Kanger
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1452-1457 (2012)
The organocatalytic Michael addition of malonates to symmetric unsaturated 1,4-diketones catalyzed by thiourea and squaramide derivatives with Cinchona alkaloids afforded the formation of a new C–C bond in high yields (up to 98%) and enantiomeric p
Externí odkaz:
https://doaj.org/article/d9dce444c75c47af81065aa7936c6058