Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Sergei Y Noskov"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229085 (2020)
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. NIS also transports other monovalent anions such as tetrafluoroborate (BF4-), pertechnetate (TcO4-), and thiocyanate (SCN-), and is competitively
Externí odkaz:
https://doaj.org/article/3193589f709e4d33bf5f0d58f5a99d91
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004482 (2016)
Crystal structures of several bacterial Na(v) channels have been recently published and molecular dynamics simulations of ion permeation through these channels are consistent with many electrophysiological properties of eukaryotic channels. Bacterial
Externí odkaz:
https://doaj.org/article/7b8ce3d62e904642831930d7f30d1057
Autor:
Jiqing Guo, Serdar Durdagi, Mohamed Changalov, Laura L Perissinotti, Jason M Hargreaves, Thomas G Back, Sergei Y Noskov, Henry J Duff
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e105553 (2014)
One of the main culprits in modern drug discovery is apparent cardiotoxicity of many lead-candidates via inadvertent pharmacologic blockade of K+, Ca2+ and Na+ currents. Many drugs inadvertently block hERG1 leading to an acquired form of the Long QT
Externí odkaz:
https://doaj.org/article/f7a4836d5fd74443b08ab39ad724be7c
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca30f9d545d92906b5d654c03d7da00
https://doi.org/10.1016/j.yjmcc.2021.05.015
https://doi.org/10.1016/j.yjmcc.2021.05.015
Autor:
Joslyn Jung, Soren Wacker, Andrew D. Fant, Jiqing Guo, Williams E. Miranda, Mary Kudaibergenova, Sergei Y. Noskov, Henry J. Duff, Lei Shi, Andy Guan, Jianjing Cao, Kuo Hao Lee, Amy Hauck Newman, Therese Ku
Publikováno v:
J Chem Inf Model
Psychostimulant drugs, such as cocaine, inhibit dopamine reuptake via blockading the dopamine transporter (DAT), which is the primary mechanism underpinning their abuse. Atypical DAT inhibitors are dissimilar to cocaine and can block cocaine- or meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2210ef7eba1109d021c6032ff145c0da
https://doi.org/10.1021/acs.jcim.1c00856
https://doi.org/10.1021/acs.jcim.1c00856
Autor:
Sergei Y. Noskov, Kenneth K.-S. Ng, David Kerk, Jordan F. Mattice, Greg B. G. Moorhead, Mario E. Valdés-Tresanco
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Phosphoprotein phosphatase (PPP) enzymes are ubiquitous proteins involved in cellular signaling pathways and other functions. Here we have traced the origin of the PPP sequences of Eukaryotes and their radiation. Using a bacterial PPP Hidden Markov M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d3102de5748c6cd193ae7fe03123e2
https://doaj.org/article/3b06f50c4dba434391b0f94c6280040b
https://doaj.org/article/3b06f50c4dba434391b0f94c6280040b
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology
Communications Biology
Voltage-gated KCNQ1 channels contain four separate voltage-sensing domains (VSDs) and a pore domain (PD). KCNQ1 expressed alone opens when the VSDs are in an intermediate state. In cardiomyocytes, KCNQ1 co-expressed with KCNE1 opens mainly when the V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b6ad3a5aa2c3fd6a8a795ba0d9ed51
https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
Autor:
Hristina R. Zhekova, Jiansen Jiang, Weiguang Wang, Kirill Tsirulnikov, Gülru Kayık, Hanif Muhammad Khan, Rustam Azimov, Natalia Abuladze, Liyo Kao, Debbie Newman, Sergei Y. Noskov, D. Peter Tieleman, Hong Zhou, Alexander Pushkin, Ira Kurtz
Publikováno v:
Biophysical Journal. 122:32a-33a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::463e0c25526b5222a11890a871316168
https://doi.org/10.1016/j.bpj.2022.11.395
https://doi.org/10.1016/j.bpj.2022.11.395
Autor:
Henry J. Duff, James P. Lees-Miller, Valentina Corradi, Jiqing Guo, Williams E. Miranda, Haydee Mesa-Galloso, D. Peter Tieleman, Sergei Y. Noskov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ebaa10fb709ec926051bfcce623e66
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
https://doaj.org/article/f5eb9a98c2804d9bb7a7f7b17805b054
Publikováno v:
J Chem Theory Comput
Despite the progress in modeling complex molecular systems of ever-increasing complexity, a quantitatively accurate computational treatment of ion permeation through narrow membrane channels remains challenging. An important factor to reach this goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626fda6f023fcb2d39c35f99ceb3aa93
https://doi.org/10.1021/acs.jctc.0c00968
https://doi.org/10.1021/acs.jctc.0c00968