Unraveling the Mechanism of Platelet Aggregation Suppression by Thioterpenoids: Molecular Docking and In Vivo Antiaggregant Activity

Autor: Liliya E. Nikitina, Pavel S. Bocharov, Alexander A. Ksenofontov, Elena V. Antina, Ilmir R. Gilfanov, Roman S. Pavelyev, Olga V. Ostolopovskaya, Inna V. Fedyunina, Zulfiya R. Azizova, Svetlana V. Pestova, Evgeniy S. Izmest’ev, Svetlana A. Rubtsova, Sergei V. Boichuk, Aigul R. Galembikova, Elena A. Smolyarchuk, Ilshat G. Mustafin, Airat R. Kayumov, Aleksandr V. Samorodov

Publikováno v: Biomimetics, Vol 8, Iss 8, p 570 (2023)

Natural monoterpenes and their derivatives are widely considered the effective ingredients for the design and production of novel biologically active compounds. In this study, by using the molecular docking technique, we examined the effects of two s

Externí odkaz: https://doaj.org/article/336677ed56414f1b96ac5f0219bc0fda

Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

Autor: Galina B. Guseva, Elena V. Antina, Mikhail B. Berezin, Anastassia S. Smirnova, Roman S. Pavelyev, Ilmir R. Gilfanov, Oksana G. Shevchenko, Svetlana V. Pestova, Evgeny S. Izmest’ev, Svetlana A. Rubtsova, Olga V. Ostolopovskaya, Sergey V. Efimov, Vladimir V. Klochkov, Ilfat Z. Rakhmatullin, Ayzira F. Timerova, Ilya A. Khodov, Olga A. Lodochnikova, Daut R. Islamov, Pavel V. Dorovatovskii, Liliya E. Nikitina, Sergei V. Boichuk

Publikováno v: Bioengineering, Vol 9, Iss 5, p 210 (2022)

This paper presents the design and a comparative analysis of the structural and solvation factors on the spectral and biological properties of the BODIPY biomarker with a thioterpene fragment. Covalent binding of the thioterpene moiety to the butanoi

Externí odkaz: https://doaj.org/article/9a292a6347e244fcbe2ef01ffad795ff

Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids

Autor: Liliya E. Nikitina, Roman S. Pavelyev, Ilmir R. Gilfanov, Sergei V. Kiselev, Zulfiya R. Azizova, Alexander A. Ksenofontov, Pavel S. Bocharov, Elena V. Antina, Vladimir V. Klochkov, Ayzira F. Timerova, Ilfat Z. Rakhmatullin, Olga V. Ostolopovskaya, Mohammed A. Khelkhal, Sergei V. Boichuk, Aigul R. Galembikova, Natalia S. Andriutsa, Larisa L. Frolova, Alexander V. Kutchin, Airat R. Kayumov

Publikováno v: Bioengineering, Vol 9, Iss 1, p 24 (2022)

Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpen

Externí odkaz: https://doaj.org/article/0f32e3e5cc6e46ee8cc6eefcd99f5219

Gut-associated plasmacytoid dendritic cells display an immature phenotype and upregulated granzyme B in subjects with HIV/AIDS

Autor: Sergei V Boichuk, Svetlana F Khaiboullina, Bulat R Ramazanov, Gulshat R Khasanova, Karina A Ivanovskaya, Evgeny Z Nizamutdinov, Marat R Sharafutdinov, Ekaterina М Martynova, Kenny L DeMeirleir, Jan eHulstaert, Vladimir A Anokhin, Albert A Rizvanov, Vincent C Lombardi

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

Plasmacytoid dendritic cells in the periphery of subjects with HIV/AIDS decrease over time and the fate of these cells has been the subject of ongoing investigation. Previous studies using animal models as well as studies with humans suggest that the

Externí odkaz: https://doaj.org/article/8d35f4987b7642abab9f23830e621936

Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid.

Autor: Guseva, Galina B.¹ (AUTHOR) gbg@isc-ras.ru, Antina, Elena V.¹ (AUTHOR) eva@isc-ras.ru, Berezin, Mikhail B.¹ (AUTHOR) mbb@isc-ras.ru, Smirnova, Anastassia S.^1,2 (AUTHOR) anactaciasmirnova@yandex.ru, Pavelyev, Roman S.³ (AUTHOR) rpavelyev@gmail.com, Gilfanov, Ilmir R.^3,4 (AUTHOR) ilmir.gilfanov@gmail.com, Shevchenko, Oksana G.⁵ (AUTHOR) microtus69@mail.ru, Pestova, Svetlana V.⁶ (AUTHOR) pestova-svetlana89@mail.ru, Izmest'ev, Evgeny S.⁶ (AUTHOR) evgeniyizmestev@rambler.ru, Rubtsova, Svetlana A.⁶ (AUTHOR) rubtsova-sa@chemi.komisc.ru, Ostolopovskaya, Olga V.^3,7 (AUTHOR) olga-ov.kirill@mail.ru, Efimov, Sergey V.³ (AUTHOR) sergej.efimov@kpfu.ru, Klochkov, Vladimir V.³ (AUTHOR) vladimir.klochkov@kpfu.ru, Rakhmatullin, Ilfat Z.³ (AUTHOR) izrahmatullin@kpfu.ru, Timerova, Ayzira F.³ (AUTHOR) ajzftimerova@kpfu.ru, Khodov, Ilya A.¹ (AUTHOR) iakh@isc-ras.ru, Lodochnikova, Olga A.⁸ (AUTHOR) lod_olga@mail.ru, Islamov, Daut R.⁹ (AUTHOR) daut1989@mail.ru, Dorovatovskii, Pavel V.¹⁰ (AUTHOR) paulgemini@mail.ru, Nikitina, Liliya E.^3,7 (AUTHOR) nikitl@mail.ru

Publikováno v: Bioengineering (Basel). May2022, Vol. 9 Issue 5, p210. 21p.