Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Sergei Spitsin"'
Autor:
Sergei Spitsin, Bruce C. Schnepp, Mary J. Connell, Tehui Liu, Christine M. Dang, Vasiliki Pappa, Richard Tustin, Annemarie Kinder, Philip R. Johnson, Steven D. Douglas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1088-1096 (2020)
Antibody-like molecules were evaluated with potent simian immunodeficiency virus (SIV) neutralizing properties (immunoadhesins) that were delivered by a recombinant adeno-associated virus (rAAV) vector in the SIV-infected rhesus macaque model. When i
Externí odkaz:
https://doaj.org/article/2ab30f67b4b54d139a27a0a61edd8bdd
Autor:
Christine M. Dang, Annemarie Kinder, Tehui Liu, Richard Tustin, Sergei Spitsin, Philip R. Johnson, Mary J. Connell, Vasiliki Pappa, Steven D. Douglas, Bruce C. Schnepp
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 1088-1096 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 1088-1096 (2020)
Antibody-like molecules were evaluated with potent simian immunodeficiency virus (SIV) neutralizing properties (immunoadhesins) that were delivered by a recombinant adeno-associated virus (rAAV) vector in the SIV-infected rhesus macaque model. When i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39633a612fdcc114583628b0e689c0ca
https://pubmed.ncbi.nlm.nih.gov/32478124
https://pubmed.ncbi.nlm.nih.gov/32478124
Autor:
Annemarie Kinder, Jay Rappaport, Dwight L. Evans, Steven D. Douglas, Sergei Spitsin, Vasiliki Pappa
Publikováno v:
Medicine
Changes in tryptophan metabolism affect human physiology including the immune system, mood, and sleep and are associated with human immunodeficiency virus (HIV) pathogenesis. This study investigates whether the treatment of HIV-infected individuals w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c2590d49840a56bbaa9c2b09667054
https://doi.org/10.1097/md.0000000000025313
https://doi.org/10.1097/md.0000000000025313
Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes
Publikováno v:
J Neuroimmunol
Neurokinin-1 receptor (NK1R) signaling can be immunomodulatory and it can lead to preferential transmigration of CD14+CD16+ monocytes across the blood brain barrier, potentially promoting the development of inflammatory neurological diseases, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac5e848c33b550f34ff770dd897f6a8
https://doi.org/10.1016/j.jneuroim.2021.577524
https://doi.org/10.1016/j.jneuroim.2021.577524
Autor:
Steven D. Douglas, Sergei Spitsin
Publikováno v:
Journal of Leukocyte Biology. 102:1155-1157
Discussion on the potential role for CXCR7 as a major signaling pathway for CD14+CD16+ monocyte transmigration across the blood brain barrier, and its therapeutic application for NeuroAIDS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c2a6f6b8405624fec3d31bacf0574f
https://doi.org/10.1189/jlb.3ce0717-273r
https://doi.org/10.1189/jlb.3ce0717-273r
Autor:
James Korelitz, Deborah Kim, Renae Catalano, Jeffrey S. Barrett, Okan U. Elci, Florin Tuluc, Sergei Spitsin, Wayne Wagner, Dwight L. Evans, Angela Winters, Pablo Tebas, Steven D. Douglas
Publikováno v:
AIDS (London, England)
Objective: We evaluated safety, antiviral, immunomodulatory and anti-inflammatory properties of aprepitant – a neurokinin 1 receptor antagonist. Design: Phase IB randomized, placebo-controlled, double-blinded study. Methods: Eighteen patients were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc0b1d042be24b3f6426374d9af5080
https://doi.org/10.1097/qad.0000000000000638
https://doi.org/10.1097/qad.0000000000000638
Autor:
Dwight L. Evans, Steven D. Douglas, Deanne Taylor, Vasiliki Pappa, Jeffrey S. Barrett, Sergei Spitsin, Pablo Tebas, Deborah Kim
Publikováno v:
JCI Insight. 2
Background HIV-infected individuals, even well controlled with combined antiretroviral therapy (cART), have systemic inflammation and comorbidities. Substance P (SP) is an undecapeptide, which mediates neurotransmission and inflammation through its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49edcb98d101324c58e80276d66b89f7
https://doi.org/10.1172/jci.insight.95893
https://doi.org/10.1172/jci.insight.95893
Publikováno v:
Journal of leukocyte biology.
Substance P (SP) is a tachykinin peptide, which triggers intracellular signaling in the nervous and immune systems, as well as, other local and systemic events. The interaction between SP and its receptor, neurokinin-1 receptor (NK1R), results in maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4844642d148e6668633106781fe5c9a7
https://pubmed.ncbi.nlm.nih.gov/29345372
https://pubmed.ncbi.nlm.nih.gov/29345372
Autor:
Jennifer L. McGuire, Steven D. Douglas, Gaurav Bajaj, Ganesh S. Moorthy, Di Wu, Xianguo Zhao, Dwight L. Evans, Sergei Spitsin, Pablo Tebas, Jeffrey S. Barrett
Publikováno v:
Current HIV Research. 12:121-131
Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc911a15c900c0ab327f3e71f0baf05
https://doi.org/10.2174/1570162x12666140526120831
https://doi.org/10.2174/1570162x12666140526120831
Publikováno v:
Journal of Leukocyte Biology. 96:143-150
Activation of NK1R by SP contributes to increased HIV-1 infection in macrophages. The scavenger receptor CD163 is expressed on cells of monocyte-macrophage origin. Our main goal was to determine if there is interplay among SP, CD163 expression, and H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca348b93a03aa0ab1a1bf588f06ce79a
https://doi.org/10.1189/jlb.4ab0813-434rr
https://doi.org/10.1189/jlb.4ab0813-434rr