Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sergei S. Likhodii"'
Publikováno v:
Epilepsia. 49:83-86
Recent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high-fat diet used to treat drug-resistant seizures, raises blood and brain levels of three ketones: beta-hydroxybutyrate,
Autor:
Kirk Nylen, W.M. Burnham, Miguel A. Cortez, Jose Luis Perez Velazquez, Khosrow Adeli, Sergei S. Likhodii, Lily Shen, K. Michael Gibson, Yevgen Leshchenko, O. Carter Snead
Publikováno v:
Experimental Neurology. 210:449-457
Succinic semialdehyde dehydrogenase (SSADH) deficiency is a heritable disorder of GABA degradation characterized by ataxia, psychomotor retardation and seizures. To date, there is no effective treatment for SSADH deficiency. We tested the hypothesis
Publikováno v:
Epilepsy Research. 71:23-31
Introduction Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD). The present study examined the ability of
Publikováno v:
Experimental Neurology. 200:283-289
Deoxycorticosterone (DOC) is a steroid hormone that suppresses seizures in both humans and animals. At higher doses, DOC's anticonvulsant actions are accompanied by sedation and ataxia. The mechanism of DOC's anticonvulsant actions is not known, alth
Autor:
Exequiel Rarama, Stephanie Benoit, Stephen C. Cunnane, Kathy Musa-Veloso, Dominic Chartrand, Sergei S. Likhodii, Rosalind Curtis, Yeou-mei Christiana Liu, Anne Lortie, Lionel Carmant, Felix J. E. Comeau
Publikováno v:
Nutrition. 22:1-8
Objective The high-fat ketogenic diet has long been used to treat refractory childhood seizures, but whether there is a relation between the degree of ketosis and effectiveness of seizure control remains unclear. Frequent measurements of plasma keton
Publikováno v:
Epilepsia. 43:1596-1599
Rho et al. (1) recently demonstrated that acetoacetateand acetone protected mice from audiogenic seizures(Epilepsia, April, 2002). The authors “propose that theanticonvulsant efficacy of the KD [ketogenic diet] maybe due in part to the accumulation
Autor:
Mary Ann Ryan, Sergei S. Likhodii, Stephen C. Cunnane, Kathy Musa, Cynthia A. Dell, W. MacIntyre Burnham
Publikováno v:
Lipids. 36:373-378
High-fat ketogenic diets are used to treat intractable seizures in children, but little is known of the mechanism by which these diets work or whether fats rich in n-3 polyunsaturates might be beneficial. Tissue lipid and fatty acid profiles were det
Publikováno v:
Journal of Molecular Neuroscience. 16:173-180
This article describes the application of in vivo 13C-nuclear magnetic resonance (NMR) spectroscopy and gas chromatography (GC)-combustion-isotope ratio mass spectrometry to the study of brain uptake and metabolism of polyunsaturated fatty acids in t
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 60:387-392
Recent reports indicate that recycling of the beta-oxidized carbon skeleton of linoleate and alpha-linolenate into newly synthesized cholesterol and fatty acids in the brain is quantitatively significant in both suckling rats and pre- and postnatally
Publikováno v:
Lipids. 31:S127-S130
As a noninvasive method, in vivo 13C nuclear magnetic resonance has potentially important applications in understanding the metabolism of long chain fatty acids in organs of living humans. At present, this methodology is most advanced for research on