Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sergei Radaev"'
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
Tomer Arnon, Marco Craveiro, Nicholas C. Love, Sergei Radaev, Nan-ping Weng, Abhisek Bhattacharya, Xiaoping Sun, Jonathan Chu, Jinghua Lu, Nir Friedman, Ingrid Saba, Eric Shifrut, Anastasia N. Tikhonova, Alfred Singer, Annette Ko, Peter D. Sun, François Van Laethem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire s
Autor:
Peter D. Sun, Polly Matzinger, Sergei Radaev, Nevil J. Singh, Hidde L. Ploegh, Eric Spooner, Kaveh Abdi, Larry M. Lantz, Benedikt M. Kessler, Tsan Sam Xiao
Publikováno v:
The Journal of Immunology. 192:6028-6036
IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place w
Autor:
Zhongcheng Zou, Pavel Tolar, Susan K. Pierce, Sergei Radaev, Anh Nguyen, Peter D. Sun, Nicole Stutzman, Peter D. Krueger, Khanh Q. Nguyen
Publikováno v:
Structure. 18:934-943
The B cell antigen receptor (BCR) plays an essential role in all phases of B cell development. Here we show that the extracellular domains of murine and human Igbeta form an I-set immunoglobulin-like structure with an interchain disulfide between cys
Publikováno v:
Journal of Biological Chemistry. 285:14806-14814
Transforming growth factor (TGF)-beta1, -beta2, and -beta3 are 25-kDa homodimeric polypeptides that play crucial nonoverlapping roles in embryogenesis, tissue development, carcinogenesis, and immune regulation. Here we report the 3.0-A resolution cry
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
In order to overcome the difficulties associated with the ‘classical’ heavy-atom derivatization procedure, an attempt has been made to develop a rational crystal-free heavy-atom-derivative screening method and a quick-soak derivatization procedur
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 65:1334-1340
Here, a case is presented of an unusual structure determination which was facilitated by the use of pseudosymmetry. Group A streptococcus uses cysteine protease Mac-1 (also known as IdeS) to evade the host immune system. Native Mac-1 was crystallized
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G809-G816
Hepatic stellate cells (HSCs) store 75% of the body's supply of vitamin A (retinol) and play a key role in liver fibrogenesis. During liver injury, HSCs become activated and susceptible to natural killer (NK) cell killing due to increased expression
Autor:
Sergei Radaev, Prateeti Khazanie, Anthony S. Fauci, Domenico Mavilio, Peter Schuck, Shyam Kottilil, Claudia Cicala, Donald Van Ryk, James Arthos, Marybeth Daucher, Ronald L. Rabin, Peter D. Sun, Eva Chung, Neil Gupta, Nina Censoplano, Catherine C. Cruz, Tavis D. Steenbeke, Margery A. Chaikin
Publikováno v:
Virology. 332:491-497
Natural killer (NK) cells play an important role in both innate and adaptive antiviral immune responses. The adaptive response typically requires that virus-specific antibodies decorate infected cells which then direct NK cell lysis through a CD16 me
Publikováno v:
Structure. 11(12):1527-1535
Triggering receptors expressed on myeloid cells (TREM) are a family of recently discovered receptors that play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to mic