Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Sergei P Boudko"'
Autor:
Delfien Syx, Yoshihiro Ishikawa, Jan Gebauer, Sergei P Boudko, Brecht Guillemyn, Tim Van Damme, Sanne D'hondt, Sofie Symoens, Sheela Nampoothiri, Douglas B Gould, Ulrich Baumann, Hans Peter Bächinger, Fransiska Malfait
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009339 (2021)
Heat shock protein 47 (HSP47), encoded by the SERPINH1 gene, is a molecular chaperone essential for correct folding of collagens. We report a homozygous p.(R222S) substitution in HSP47 in a child with severe osteogenesis imperfecta leading to early d
Externí odkaz:
https://doaj.org/article/d344019aa7d94c4093a3bd9e3e2f09b8
Autor:
Aaron L Fidler, Carl E Darris, Sergei V Chetyrkin, Vadim K Pedchenko, Sergei P Boudko, Kyle L Brown, W Gray Jerome, Julie K Hudson, Antonis Rokas, Billy G Hudson
Publikováno v:
eLife, Vol 6 (2017)
The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of th
Externí odkaz:
https://doaj.org/article/e19f2cf7fd724dce8e52fab510ae0f42
Publikováno v:
Curr Opin Nephrol Hypertens
PURPOSE OF REVIEW: In Alport syndrome, over 1,700 genetic variants in the COL4A3, COL4A4, and COL4A5 genes cause the absence or malfunctioning of the collagen IV(α345) scaffold – an essential component of the glomerular basement membrane (GBM). Th
Autor:
Nancy R. Forde, Aaron Lyons, Sergei P. Boudko, Billy G. Hudson, Alaa Al-Shaer, Yoshihiro Ishikawa
Publikováno v:
Biophys J
Biophysical journal, vol 120, iss 18
Biophysical journal, vol 120, iss 18
Extracellular matrix mechanics influence diverse cellular functions, yet surprisingly little is known about the mechanical properties of their constituent collagen proteins. In particular, network-forming collagen IV, an integral component of basemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add8b3befd845a08ae75098219948afb
https://europepmc.org/articles/PMC8510973/
https://europepmc.org/articles/PMC8510973/
Autor:
Vadim Pedchenko, Alaa Al-Shaer, Billy G. Hudson, Ryan Bauer, Sergei P. Boudko, Elena Pokidysheva, Aaron L. Fidler, Nancy R. Forde
Publikováno v:
The Journal of Biological Chemistry
Collagen IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matrix that is essential for animal multicellularity and tissue evolution. Scaffold assembly begins with the trimerization of α-chains into prot
Autor:
Juan Saus, Tatiana Mikhailova, Billy G. Hudson, Jean-Christophe Harmange, Mary C Barber, Vadim Pedchenko, Sergei P. Boudko
Publikováno v:
The Journal of Biological Chemistry
We identified a genetic variant, an 8-residue appendage, of the α345 hexamer of collagen IV present in patients with glomerular basement membrane (GBM) disease, Goodpasture's disease (GP) and Alport syndrome (AS) (see Companion Paper I), and determi
Autor:
Ayeza Bajwa, J Steffan Bond, Charles Keller, Sergei P. Boudko, Sakir H. Gultekin, Atiya Mansoor, Megan M. Cleary, Teagan P. Settelmeyer, Christopher P. Hartley, Noah E. Berlow, Melvin Lathara, Hans Peter Bächinger, Elena Pokidysheva, Takako Sasaki, Jack F. Shern, Narendra Bharathy, Xiaolei Lian, Ganapati Srinivasa
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood with a propensity to metastasize. Current treatment for patients with RMS includes conventional systemic chemotherapy, radiation therapy, and surgical resection; nevertheless,
Autor:
Brecht Guillemyn, Fransiska Malfait, Sofie Symoens, Jan M. Gebauer, Sheela Nampoothiri, Tim Van Damme, Hans Peter Bächinger, Douglas B. Gould, Yoshihiro Ishikawa, Sergei P. Boudko, Sanne D'hondt, Ulrich Baumann, Delfien Syx
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009339 (2021)
PLoS Genetics
PLOS GENETICS
PLoS genetics, vol 17, iss 2
PLoS Genetics
PLOS GENETICS
PLoS genetics, vol 17, iss 2
Heat shock protein 47 (HSP47), encoded by the SERPINH1 gene, is a molecular chaperone essential for correct folding of collagens. We report a homozygous p.(R222S) substitution in HSP47 in a child with severe osteogenesis imperfecta leading to early d
Autor:
Nancy R. Forde, Billy G. Hudson, Sergei P. Boudko, Alaa Al-Shaer, Aaron Lyons, Yoshihiro Ishikawa
Extracellular matrix mechanics influence diverse cellular functions, yet surprisingly little is known about the mechanical properties of their constituent collagen proteins. In particular, network-forming collagen IV, an integral component of basemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f643c6a09a47e05ffbafbd00c5fc3525
https://doi.org/10.1101/2020.09.27.315929
https://doi.org/10.1101/2020.09.27.315929
Publikováno v:
Advances in experimental medicine and biology. 21
Collagen molecules are crucial extracellular players in animal tissue development and in functions ranging from ultrafiltration to organism locomotion. Among the 28 types of collagen found in human, type IV collagen stands out as a primordial type fo