Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Sergei M. Mirkin"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Genomic inversions come in various sizes. While long inversions are relatively easy to identify by aligning high-quality genome sequences, unambiguous identification of microinversions is more problematic. Here, using a set of extra stringen
Externí odkaz:
https://doaj.org/article/cecdfb4a11f946f584fd69a6fd4499d4
Autor:
Lei Qi, Yang Sui, Xing-Xing Tang, Ryan J. McGinty, Xiao-Zhuan Liang, Margaret Dominska, Ke Zhang, Sergei M. Mirkin, Dao-Qiong Zheng, Thomas D. Petes
Publikováno v:
PLoS Genetics, Vol 19, Iss 1 (2023)
Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of the underlying mechanisms are not fully clarified. In the genome of the yeast Saccharomyce
Externí odkaz:
https://doaj.org/article/59f100f8d4d6417ca7d113285421aebc
Autor:
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 1-64 (2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily
Externí odkaz:
https://doaj.org/article/9deb4e4edc524ec78e599b9f614eaef3
Autor:
Ryan J. McGinty, Franco Puleo, Anna Y. Aksenova, Julia A. Hisey, Alexander A. Shishkin, Erika L. Pearson, Eric T. Wang, David E. Housman, Claire Moore, Sergei M. Mirkin
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2490-2500 (2017)
Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. Whereas the length of an expandable repeat is the main factor determining disease inheritance, re
Externí odkaz:
https://doaj.org/article/0dfcf17ded7242c7a59c4d6e7f1ea13e
Autor:
Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J.B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby, John A. Tainer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion b
Externí odkaz:
https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1545-1551 (2015)
Telomeric repeats located within chromosomes are called interstitial telomeric sequences (ITSs). They are polymorphic in length and are likely hotspots for initiation of chromosomal rearrangements that have been linked to human disease. Using our S.
Externí odkaz:
https://doaj.org/article/a31c71a4dcdf4b5da45f34562c496a10
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1594-1602 (2014)
Summary: Expansions of simple DNA repeats cause numerous hereditary disorders in humans. Replication, repair, and transcription are implicated in the expansion process, but their relative contributions are yet to be distinguished. To separate the rol
Externí odkaz:
https://doaj.org/article/ee757d9e9c4e466db8710076d8ffe8ff
Autor:
Kartik A. Shah, Alexander A. Shishkin, Irina Voineagu, Youri I. Pavlov, Polina V. Shcherbakova, Sergei M. Mirkin
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1088-1095 (2012)
Expansions of simple DNA repeats cause numerous hereditary diseases in humans. We analyzed the role of DNA polymerases in the instability of Friedreich’s ataxia (GAA)n repeats in a yeast experimental system. The elementary step of expansion corresp
Externí odkaz:
https://doaj.org/article/2f69603835824da29a6e489fc9c02e41
Autor:
Anastasia Rastokina, Jorge Cebrián, Negin Mozafari, Nicholas H Mandel, C I Edvard Smith, Massimo Lopes, Rula Zain, Sergei M Mirkin
Publikováno v:
Nucleic Acids Research.
Friedreich's ataxia (FRDA) is caused by expansions of GAA•TTC repeats in the first intron of the human FXN gene that occur during both intergenerational transmissions and in somatic cells. Here we describe an experimental system to analyze large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7698b6f4561fc78003a03e00521cd4b6
https://doi.org/10.1093/nar/gkad441
https://doi.org/10.1093/nar/gkad441
Publikováno v:
DNA Repair (Amst)
Trinucleotide repeat instability is a driver of human disease. Large expansions of (GAA)(n) repeats in the first intron of the FXN gene are the cause Friedreich’s ataxia (FRDA), a progressive degenerative disorder which cannot yet be prevented or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c21297e4542ccb5fe49d344b03046d8
https://europepmc.org/articles/PMC9675320/
https://europepmc.org/articles/PMC9675320/
