Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sergei Kotelnikov"'
Autor:
Weiwei Lin, Fatemeh Mousavi, Benjamin C. Blum, Christian F Heckendorf, Jarrod Moore, Noah Lampl, Mark McComb, Sergei Kotelnikov, Wenqing Yin, Nabil Rabhi, Matthew D. Layne, Dima Kozakov, Vipul C. Chitalia, Andrew Emili
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/33ee9d82e5ee4ea6aa206bbda5becf0a
Autor:
Weiwei Lin, Fatemeh Mousavi, Benjamin C. Blum, Christian F. Heckendorf, Jarrod Moore, Noah Lampl, Mark McComb, Sergei Kotelnikov, Wenqing Yin, Nabil Rabhi, Matthew D. Layne, Dima Kozakov, Vipul C. Chitalia, Andrew Emili
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: We hypothesize that the poor survival outcomes of end-stage kidney disease (ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and selectivity. The current gold standard criteria using single or several
Externí odkaz:
https://doaj.org/article/91d9e4ead7ca4cef9effc79622d55726
Autor:
Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon, Heather Hook, Gopal Karemore, Michael U. J. Oliphant, Weiwei Lin, Qian Liu, Sadhna Phanse, Carl White, Dzmitry Padhorny, Sergei Kotelnikov, Christopher S. Chen, Pingzhao Hu, Gerald V. Denis, Dima Kozakov, Brian Raught, Trevor Siggers, Stefan Wuchty, Senthil K. Muthuswamy, Andrew Emili
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Epithelial-to-mesenchymal transition (EMT) is a complex process regulated at multiple molecular levels. Here, the authors implement an analytic framework - PAMAF - to integrate data from twelve distinct omics modalities, which they use to understand
Externí odkaz:
https://doaj.org/article/f07b77169d2c404490c225320410df32
Autor:
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Co-fractionation/mass spectrometry (CF/MS) allows mapping protein interactomes but efficiency and quantitative accuracy are limited. Here, the authors develop a reproducible multiplexed CF/MS method and apply it to characterize interactome rewiring i
Externí odkaz:
https://doaj.org/article/016eb71f96c6424398ad8b774268e539
Autor:
Megan Egbert, Kathryn A. Porter, Usman Ghani, Sergei Kotelnikov, Thu Nguyen, Ryota Ashizawa, Dima Kozakov, Sandor Vajda
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2549-2566 (2021)
We study the models submitted to round 12 of the Critical Assessment of protein Structure Prediction (CASP) experiment to assess how well the binding properties are conserved when the X-ray structures of the target proteins are replaced by their mode
Externí odkaz:
https://doaj.org/article/fb570d50938e430d9a58d13c5c7cd359
Autor:
Mikhail Ignatov, Akhil Jindal, Sergei Kotelnikov, Dmitri Beglov, Ganna Posternak, Xiaojing Tang, Pierre Maisonneuve, Gennady Poda, Robert A. Batey, Frank Sicheri, Adrian Whitty, Peter J. Tonge, Sandor Vajda, Dima Kozakov
Publikováno v:
Journal of the American Chemical Society. 145:7123-7135
Autor:
Israel T. Desta, Sergei Kotelnikov, George Jones, Usman Ghani, Mikhail Abyzov, Yaroslav Kholodov, Daron M. Standley, Maria Sabitova, Dmitri Beglov, Sandor Vajda, Dima Kozakov
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 91:171-182
Antibodies are key proteins produced by the immune system to target pathogen proteins termed antigens via specific binding to surface regions called epitopes. Given an antigen and the sequence of an antibody the knowledge of the epitope is critical f
Autor:
Qisi Zhang, Cyrille S. Kounde, Milon Mondal, Jake L. Greenfield, Jennifer R. Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P. Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D. Harling, Matthew J. Fuchter, Edward W. Tate
Publikováno v:
ChemComm
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PRO
Autor:
Shi-Jie Chen, Mubashir Hassan, Robert L. Jernigan, Kejue Jia, Daisuke Kihara, Andrzej Kloczkowski, Sergei Kotelnikov, Dima Kozakov, Jie Liang, Adam Liwo, Silvina Matysiak, Jarek Meller, Cristian Micheletti, Julie C. Mitchell, Sayantan Mondal, Ruth Nussinov, Kei-ichi Okazaki, Dzmitry Padhorny, Jeffrey Skolnick, Tobin R. Sosnick, George Stan, Ilya Vakser, Xiaoqin Zou, George D. Rose
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
Autor:
Usman Ghani, Israel Desta, Sergei Kotelnikov, Ryota Ashizawa, Dima Kozakov, Dzmitry Padhorny, Megan Egbert, Nasser Hashemi, Sandor Vajda, Thu Nguyen
Publikováno v:
Proteins
An important question is how well the models submitted to CASP retain the properties of target structures. We investigate several properties related to binding. First we explore the binding of small molecules as probes, and count the number of intera