Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Sergei B, Vakulenko"'
Autor:
Nichole K. Stewart, Marta Toth, Maha A. Alqurafi, Weirui Chai, Thu Q. Nguyen, Pojun Quan, Mijoon Lee, John D. Buynak, Clyde A. Smith, Sergei B. Vakulenko
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Acinetobacter baumannii has become a major nosocomial pathogen, as it is often multidrug-resistant, which results in infections characterized by high mortality rates. The bacterium achieves high levels of resistance to β-lactam antibiotics
Externí odkaz:
https://doaj.org/article/9e0cf59bc3db4dbab2fa79a250ae777e
Autor:
Clyde A. Smith, Nichole K. Stewart, Marta Toth, Pojun Quan, John D. Buynak, Sergei B. Vakulenko
Publikováno v:
ACS Infectious Diseases. 9:1123-1136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a66a5226d876202a519a61a686db0a3
https://doi.org/10.1021/acsinfecdis.3c00059
https://doi.org/10.1021/acsinfecdis.3c00059
Publikováno v:
ACS infectious diseases. 8(9)
l,d-Transpeptidases (LDTs) are enzymes that catalyze reactions essential for biogenesis of the bacterial cell wall, including formation of 3-3 cross-linked peptidoglycan. Unlike the historically well-known bacterial transpeptidases, the penicillin-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::101ceef97346b503fc9b11a81ebe9ce7
https://pubmed.ncbi.nlm.nih.gov/35973205
https://pubmed.ncbi.nlm.nih.gov/35973205
Publikováno v:
Microbial Cell, Vol 4, Iss 12, Pp 402-410 (2017)
Aminoglycoside 6’-acetyltransferase-Im (AAC(6’)-Im) is the closest monofunctional homolog of the AAC(6’)-Ie acetyltransferase of the bifunctional enzyme AAC(6’)-Ie/APH(2”)-Ia. The AAC(6’)-Im acetyltransferase confers 4- to 64-fold higher
Externí odkaz:
https://doaj.org/article/ecfe44566b3e4377933389bbde0de982
Publikováno v:
ACS Infectious Diseases. 8:1948-1961
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30a65c0b5e40b4b74ffbbc7f4bb7c6c
https://doi.org/10.1021/acsinfecdis.2c00321
https://doi.org/10.1021/acsinfecdis.2c00321
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown
Externí odkaz:
https://doaj.org/article/8081a353a6874a4090b4509fee48d0d5
Autor:
Marta Toth, Mijoon Lee, Clyde A. Smith, Anastasiya Stasyuk, Sergei B. Vakulenko, Nichole K. Stewart
Publikováno v:
ACS Infectious Diseases. 7:1164-1176
Avibactam is a potent diazobicyclooctane inhibitor of class A and C β-lactamases. The inhibitor also exhibits variable activity against some class D enzymes from Gram-negative bacteria; however, its interaction with recently discovered class D β-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cfead5141e9a09a0a47e5591886363f
https://doi.org/10.1021/acsinfecdis.0c00714
https://doi.org/10.1021/acsinfecdis.0c00714
Publikováno v:
Antimicrob Agents Chemother
Resistance to β-lactams, the most used antibiotics worldwide, constitutes the major problem for the treatment of bacterial infections. In the nosocomial pathogen Acinetobacter baumannii, β-lactamase-mediated resistance to the carbapenem family of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da928e9aef090579942ab89489571c30
https://europepmc.org/articles/PMC8765447/
https://europepmc.org/articles/PMC8765447/
Publikováno v:
Acta Crystallogr D Struct Biol
Aminoglycoside phosphotransferases (APHs) are one of three families of aminoglycoside-modifying enzymes that confer high-level resistance to the aminoglycoside antibiotics via enzymatic modification. This has now rendered many clinically important dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c04e5d437908cfcac6da0d4e736febd
https://doi.org/10.1107/s2059798319015079
https://doi.org/10.1107/s2059798319015079
Publikováno v:
ACS Infect Dis
Class D β-lactamases have risen to notoriety due to their wide spread in bacterial pathogens, propensity to inactivate clinically important β-lactam antibiotics, and ability to withstand inhibition by the majority of classical β-lactamase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f32caceb6cc1ea9a7b157707092de0
https://europepmc.org/articles/PMC8808381/
https://europepmc.org/articles/PMC8808381/