Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sergei Atamas"'
Autor:
Violeta Rus, Alexandru Tatomir, Vinh Nguyen, Ana Talpos-Caia, John Papadimitriou, Sergei Atamas, Irina Luzina, Sun-Sang J Sung, Tudor Badea, Horea Rus
Publikováno v:
The Journal of Immunology. 202:132.3-132.3
Response Gene to Complement (RGC)-32 is a cell cycle regulator induced by complement activation, growth factors and cytokines. RGC-32 mediates TGF-β dependent profibrotic pathways, while in immune cells promotes the differentiation of Th17 cells in
Publikováno v:
The Journal of Immunology. 192:181.22-181.22
IL-33 levels and activity are differentially associated with Th1 and Th2 phenotypes. IL-33 mRNA is rapidly regulated but the fate of synthesized IL-33 protein is unknown. To assess the interplay between IL-33, IFN-γ, and IL-4 proteins, replication-d
Publikováno v:
The Journal of Immunology. 190:46.6-46.6
IL-33 precursor (IL33PR) released from damaged cells is known to bind to the receptor T1/ST2 and activate cells in culture. However, we found that in patients with interstitial lung diseases (ILD) and in the bleomycin mouse model of lung injury, pulm
Publikováno v:
The Journal of Immunology. 190:138.17-138.17
Ultraviolet irradiation (UV) induced cellular damage is classically associated with apoptosis and known to result in systemic immunosuppression. How the decision to undergo apoptosis is made following UV is not fully understood. We hypothesize that a
Autor:
Sergei Atamas, Edward Pickering, Pavel Kopach, Phillip Kang, Virginia Lockatell, John Papadimitriou, Andrew McKenzie, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:120.30-120.30
IL-33 is a key regulator of inflammation and immunity. It remains controversial whether protease-mediated activation of IL-33 is needed for functional effects. We constructed and validated recombinant adenoviruses for gene delivery of full-length mou
Autor:
Sergei Atamas, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:44.3-44.3
CCL18 is an orphan chemokine present in primates but not in mice. Human CCL18 is fully functional in mice in vivo: it is chemotactic to mouse T lymphocytes similar to its effect on human T cells, suggesting that although mice have lost CCL18 after ev
Autor:
Pavel Kopach, Virginia Lockatell, Phillip Kang, Edward Pickering, Sergei Atamas, Irina Luzina
Publikováno v:
The Journal of Immunology. 188:120.8-120.8
Previous reports have been inconsistent on whether Interleukin (IL)-33 necessarily promotes Th2 effects in vivo. This diversity of findings may be due to post-synthetic processing of IL-33. We compared the in vivo effects of full-length mouse (flm) a
Publikováno v:
The Journal of Immunology. 186:117.15-117.15
Interleukin-4 is naturally produced in two splice isoforms, one encoded by exons 1-4 (IL-4), and the other encoded by exons 1, 3, and 4 (IL-4δ2). Our recent studies have suggested that both variants are biologically active in vivo, with partially ov
Autor:
Irina Luzina, Virginia Lockatell, Phillip Kang, Yulia Bashkatova, Sergey Andreev, Sergei Atamas
Publikováno v:
The Journal of Immunology. 186:117.14-117.14
A natural splice variant of IL-4 mRNA omits exon 2. It is unknown whether a corresponding protein, IL-4δ2, is also naturally produced. We have developed an mAb against IL-4δ2 with no cross-reactivity against IL-4. Freshly purified T cells from 8 pa
Publikováno v:
The Journal of Immunology. 186:166.23-166.23
Inflammation is often accompanied by fever, which may affect patients' survival in severe acute diseases. Pulmonary epithelium is involved in lung inflammation, and a major role for microRNAs has been suggested. To determine whether febrile temperatu