Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sergei A. Sosunov"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e75-e76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6108c17b28916f33564a518f94d639
https://doi.org/10.1016/j.bbabio.2018.09.226
https://doi.org/10.1016/j.bbabio.2018.09.226
Autor:
Sean P. Mazer, Michael E. Sughrue, Marina Botto, E. Sander Connolly, Casper Caspersen, Vadim S. Ten, Raymond I. Stark, Sergei A. Sosunov, David J. Pinsky
Publikováno v:
Stroke. 36:2244-2250
Background and Purpose—This study was undertaken to determine whether the initial component of the classical complement (C) activation pathway contributes to hypoxic-ischemic brain injury in neonatal mice.Methods—Hypoxia-ischemia (HI) was produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa71d615ee08556ff352a3650fd60b7
https://doi.org/10.1161/01.str.0000182237.20807.d0
https://doi.org/10.1161/01.str.0000182237.20807.d0
Autor:
Dzmitry Matsiukevich, Veniamin Ratner, Vadim S. Ten, Zoya V. Niatsetskaya, Irina Utkina-Sosunova, Anatoly A. Starkov, Sergei A. Sosunov
Oxidative stress and Ca2+toxicity are mechanisms of hypoxic–ischemic (HI) brain injury. This work investigates if partial inhibition of mitochondrial respiratory chain protects HI brain by limiting a generation of oxidative radicals during reperfus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d1f84945df2fefec6ac838521c6877
https://europepmc.org/articles/PMC3296485/
https://europepmc.org/articles/PMC3296485/
Autor:
Marc L. Otten, Brad E. Zacharia, E. Sander Connolly, Grace H. Kim, Michal A. Rynkowski, Matthew C. Garrett, John D. Lambris, Sergei A. Sosunov, Andrew F. Ducruet, Benjamin Hassid, Ricardo J. Komotar
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29(1)
Neuroprotective therapy targeting the complement cascade may reduce injury associated with intracerebral hemorrhage (ICH). We investigated the role of C3a-receptor antagonist (C3aRA) after ICH in mice. Autologous whole blood was infused into the righ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737d888c9212f53751a63908f583d8d
https://pubmed.ncbi.nlm.nih.gov/18728680
https://pubmed.ncbi.nlm.nih.gov/18728680
Autor:
William J. Mack, Ricardo J. Komotar, E. Sander Connolly, Zachary L. Hickman, Marc L. Otten, J. Mocco, Sergei A. Sosunov, Andrew F. Ducruet, Benjamin Hassid, David J Fusco, Grace H. Kim
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(5)
The complement anaphylatoxin C3a contributes to injury after cerebral ischemia in mice. This study assesses the effect of C3a receptor antagonist (C3aRA) on leukocyte infiltration into the ischemic zone. Transient or permanent middle cerebral artery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483ca70e43bcd39736513b8ab3a175eb
https://pubmed.ncbi.nlm.nih.gov/18197178
https://pubmed.ncbi.nlm.nih.gov/18197178
Autor:
Sander Connolly, Sergei A. Sosunov, Brad E. Zacharia, Andrew F. Ducruet, Robert M. Starke, David K. Hahn, Michal A. Rynkowski, Grace H. Kim, Ricardo J. Komotar, Matthew C. Garrett, Maxwell B. Merkow, Byung Moon Cho, Marc L. Otten, Christopher P. Kellner
Publikováno v:
Nature protocols. 3(1)
The development of controllable and reproducible animal models of intracerebral hemorrhage (ICH) is essential for the systematic study of the pathophysiology and treatment of hemorrhagic stroke. In recent years, we have used a modified version of a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80edeb377d2ed020b082b8d14b09873
https://pubmed.ncbi.nlm.nih.gov/18193028
https://pubmed.ncbi.nlm.nih.gov/18193028
Autor:
Ricardo J. Komotar, Robert B. MacArthur, E. Sander Connolly, Paulina Sergot, J. Mocco, Thomas P. Kennedy, Marc L. Otten, Sergei A. Sosunov, Andrew F. Ducruet, Corbett E. Shelton
Publikováno v:
Neurosurgery. 61(6)
OBJECTIVE: Inflammatory cascades play a significant role in progressive neurological injury after transient cerebral ischemia. It has been demonstrated that heparin, a potent anticoagulant, also possesses anti-inflammatory properties that diminish po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b870dd575fc9b726ce06f9aa85525
https://pubmed.ncbi.nlm.nih.gov/18162910
https://pubmed.ncbi.nlm.nih.gov/18162910
Autor:
Robert R. Sciacca, Yuan Zhang, J. Mocco, Henry C. Marsh, William J. Mack, E. Sander Connolly, Alexander L. Coon, Michael E. Sughrue, David J. Pinsky, Sergei A. Sosunov, Andrew F. Ducruet, Ryan G. King
Publikováno v:
Journal of neurosurgery. 105(4)
Object Postischemic cerebral inflammatory injury has been extensively investigated in an effort to develop effective neuroprotective agents. The complement cascade has emerged as an important contributor to postischemic neuronal injury. Soluble compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df86e3e0eda7442a4a9e764511ea89
https://pubmed.ncbi.nlm.nih.gov/17044564
https://pubmed.ncbi.nlm.nih.gov/17044564
Autor:
J, Mocco, Michael E, Sughrue, Andrew F, Ducruet, Ricardo J, Komotar, Sergei A, Sosunov, E Sander, Connolly
Publikováno v:
Advances in experimental medicine and biology. 586
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5a2e94c640241e89239ae087f442507
https://pubmed.ncbi.nlm.nih.gov/16893073
https://pubmed.ncbi.nlm.nih.gov/16893073
Autor:
H. Holland, Michael E. Sughrue, Sergei A. Sosunov, Andrew F. Ducruet, Ilya Laufer, J. Mocco, William J. Mack, Benjamin Hassid, E. Sander Connolly, M. Nathan Nair, David J. Pinsky, Ricardo J. Komotar, M. Claire
Publikováno v:
Circulation research. 99(2)
The complement cascade has been implicated in ischemia/reperfusion injury, and recent studies have shown that complement inhibition is a promising treatment option for acute stroke. The development of clinically useful therapies has been hindered, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251d2608f79a3d049c157d92a1bd8d92
https://pubmed.ncbi.nlm.nih.gov/16778128
https://pubmed.ncbi.nlm.nih.gov/16778128