The Role of Ion Channels and Intracellular Signaling Cascades in the Inhibitory Action of WIN 55,212-2 upon Hyperexcitation

Autor: Sergei A. Maiorov, Denis P. Laryushkin, Kristina A. Kritskaya, Valery P. Zinchenko, Sergei G. Gaidin, Artem M. Kosenkov

Publikováno v: Brain Sciences, Vol 14, Iss 7, p 668 (2024)

Gi-coupled receptors, particularly cannabinoid receptors (CBRs), are considered perspective targets for treating brain pathologies, including epilepsy. However, the precise mechanism of the anticonvulsant effect of the CBR agonists remains unknown. W

Externí odkaz: https://doaj.org/article/7a2581e34c8d442186c4a612aaed5c0f

Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons

Autor: Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Sergei G. Gaidin, Artem M. Kosenkov

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10342 (2021)

Epileptic discharges manifest in individual neurons as abnormal membrane potential fluctuations called paroxysmal depolarization shift (PDS). PDSs can combine into clusters that are accompanied by synchronous oscillations of the intracellular Ca2+ co

Externí odkaz: https://doaj.org/article/a5a790d8dbbb42e08499db2879cc79c0

Of the Mechanisms of Paroxysmal Depolarization Shifts: Generation and Maintenance of Bicuculline-Induced Paroxysmal Activity in Rat Hippocampal Cell Cultures

Autor: Kosenkov, Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Valentina N. Mal’tseva, Sergei G. Gaidin, Artem M.

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10991

Abnormal depolarization of neuronal membranes called paroxysmal depolarization shift (PDS) represents a cellular correlate of interictal spikes. The mechanisms underlying the generation of PDSs or PDS clusters remain obscure. This study aimed to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::ac7709694e07d3a5b04f19eb60b1da58

Analytical approximation of cross sections of collisions of electrons with atoms of inert gases

Autor: Rusudan Golyatina, Sergei A. Maiorov

Publikováno v: ADVANCES IN APPLIED PHYSICS. 9:298-309

The paper presents an analysis of data on the cross sections of elastic and inelastic collisions of electronswith noble gas atoms. The transport (diffusion) cross section, the excitation and ionization cross sectionsare considered. The bibliography o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f0f7932ca6239624e9780e364dd541
https://doi.org/10.51368/2307-4469-2021-9-4-298-309

Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons

Autor: S. G. Gaidin, Denis P. Laryushkin, Valery P. Zinchenko, Artem M. Kosenkov, Sergei A. Maiorov

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10342, p 10342 (2021)

Epileptic discharges manifest in individual neurons as abnormal membrane potential fluctuations called paroxysmal depolarization shift (PDS). PDSs can combine into clusters that are accompanied by synchronous oscillations of the intracellular Ca2+ co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67790e5963a58a7b521813d57552d95c
https://doi.org/10.3390/ijms221910342