Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Sergei A. MAKAROV"'
Autor:
Alexander Medvedev, Matt Moeser, Liubov Medvedeva, Elena Martsen, Alexander Granick, Lydia Raines, Kristen Gorman, Benjamin Lin, Ming Zeng, Keith A. Houck, Sergei S. Makarov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple
Externí odkaz:
https://doaj.org/article/7b4fcb73a0c54a51a995d71c913737bf
Autor:
Anna J. Esser, Srijan Mukherjee, Ilia A. Dereven’kov, Sergei V. Makarov, Donald W. Jacobsen, Ute Spiekerkoetter, Luciana Hannibal
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104981- (2022)
Summary: Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization of vitamin B12 (B12) lead to hematological and neurological manifestations. The cblC disease (cobalamin complementation type C) is an autosomal
Externí odkaz:
https://doaj.org/article/d32f9e26ac984271a06d8dcd8312fed9
Autor:
Naiem T. Issa, Henri Wathieu, Eric Glasgow, Ivana Peran, Erika Parasido, Tianqi Li, Cynthia M. Simbulan-Rosenthal, Dean Rosenthal, Alexander V. Medvedev, Sergei S. Makarov, Christopher Albanese, Stephen W. Byers, Sivanesan Dakshanamurthy
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 233, Iss , Pp 113330- (2022)
Environmental chemical (EC) exposures and our interactions with them has significantly increased in the recent decades. Toxicity associated biological characterization of these chemicals is challenging and inefficient, even with available high-throug
Externí odkaz:
https://doaj.org/article/26448e49f228463b8b6d816dcd967f02
Publikováno v:
Journal of Porphyrins and Phthalocyanines. 27:811-817
Medicinal effects of hydrophobic derivatives of vitamin [Formula: see text] have been insignificantly investigated primarily due to their low solubility in aqueous solutions. One of the ways to increase their water solubility is the complexation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67cea3f563f3644bd344ec5372c8b2e6
https://doi.org/10.1142/s1088424623500633
https://doi.org/10.1142/s1088424623500633
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1065 (2021)
Hydrogen sulfide (H2S) is a gasotransmitter and the smallest signaling thiol metabolite with important roles in human health. The turnover of H2S in humans is mainly governed by enzymes of sulfur amino acid metabolism and also by the microbiome. As i
Externí odkaz:
https://doaj.org/article/7aa0ef4bb4fe42e3b884becd3a82f242
Autor:
Ilia A. Dereven’kov, Vladimir S. Osokin, Pavel A. Molodtsov, Anna S. Makarova, Sergei V. Makarov
Publikováno v:
Reaction Kinetics, Mechanisms and Catalysis. 135:1469-1483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::791cf1ad183e9cbfdd63df8133549287
https://doi.org/10.1007/s11144-022-02216-8
https://doi.org/10.1007/s11144-022-02216-8
Autor:
Alexander V. Medvedev, Sergei Makarov, Lyubov A. Medvedeva, Elena Martsen, Kristen L. Gorman, Benjamin Lin, Sergei S. Makarov
Idiosyncratic drug-induced liver injury (DILI) is the leading cause of post-marketing drug withdrawal. Here, we describe a straightforward DILI liability assessment approach based on fingerprinting cell signaling responses. The readout is the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc89f710c2e399d47337f5c9a4386dd2
https://doi.org/10.1101/2022.12.01.518765
https://doi.org/10.1101/2022.12.01.518765
Publikováno v:
Russian Journal of Physical Chemistry A. 95:2020-2024
A study on the kinetics of the reaction between cyanocobalamin (vitamin B12, CNCbl) and the reduced form of flavin mononucleotide (FMNH2) in weakly acidic, neutral, and slightly alkaline media is performed. It is shown that FMNH2 can reduce CNCbl to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b835db1ad19397ff2c7549cef4a4c4
https://doi.org/10.1134/s003602442110006x
https://doi.org/10.1134/s003602442110006x
Autor:
Sergei V. Makarov, Maria Lehene, Nicolae Leopold, Adrian M.V. Brânzanic, Stefania Ionescu-Zinca, Radu Silaghi-Dumitrescu, Stefania D. Iancu, Diana Plesa
Publikováno v:
Inorganic Chemistry. 60:12681-12684
Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05cbc6003bdca23230b0350487551ec
https://doi.org/10.1021/acs.inorgchem.1c01483
https://doi.org/10.1021/acs.inorgchem.1c01483
Publikováno v:
Reaction Kinetics, Mechanisms and Catalysis. 133:73-84
In this work, we showed that aquacobalamin (H2OCbl) undergoes decomposition in the presence of glucose oxidase and glucose under aerobic conditions at pH 6.3. This process is contributed by two reactions performed by glucose oxidase, i.e. (i) H2OCbl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be87a5e1b238228270958428a67c0ef
https://doi.org/10.1007/s11144-021-01992-z
https://doi.org/10.1007/s11144-021-01992-z