Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sergei A Kirov"'
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22351 (2011)
Spreading depolarizations that occur in patients with malignant stroke, subarachnoid/intracranial hemorrhage, and traumatic brain injury are known to facilitate neuronal damage in metabolically compromised brain tissue. The dramatic failure of brain
Externí odkaz:
https://doaj.org/article/6a02d8b6fd8c409eab3f14758dabd6ca
Autor:
Jacob Kumro, Ashutosh Tripathi, Yun Lei, Jeremy Sword, Patrick Callahan, Alvin Terry, Xin-yun Lu, Sergei A Kirov, Anilkumar Pillai, David T Blake
Publikováno v:
Cerebral Cortex.
The etiology of Alzheimer’s dementia has been hypothesized in terms of basal forebrain cholinergic decline, and in terms of reflecting beta-amyloid neuropathology. To study these different biological elements, we activated the basal forebrain in 5x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3ef35cb292b5b03148c94b0944eb1b6
https://doi.org/10.1093/cercor/bhad066
https://doi.org/10.1093/cercor/bhad066
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991).
High astroglial capacity for glutamate and potassium clearance aids in recovering spreading depolarization (SD)-evoked disturbance of ion homeostasis during stroke. Since perisynaptic astroglia cannot be imaged with diffraction-limited light microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f97ab493c1523cb742cc33a747d9692
https://pubmed.ncbi.nlm.nih.gov/36368909
https://pubmed.ncbi.nlm.nih.gov/36368909
Autor:
Iris Álvarez‐Merz, Ioulia V. Fomitcheva, Jeremy Sword, Jesús M. Hernández‐Guijo, José M. Solís, Sergei A. Kirov
Bleeding into cerebral parenchyma during hemorrhagic stroke or head trauma leads to ischemia and release of plasmatic content, including amino acids (AA). Although excitotoxic AA have been extensively studied, little is known about non-excitatory AA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6537aacdf7b559b65cee42d44eeebdc
https://doi.org/10.1101/2022.05.10.491362
https://doi.org/10.1101/2022.05.10.491362
Autor:
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei. A. Kirov, Michael Müller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Background: When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopardized neurons. One crucial reason is that we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe864e07338390ac93ed1c0a207aabc3
https://doi.org/10.1007/s12028-021-01431-w
https://doi.org/10.1007/s12028-021-01431-w
Autor:
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Müller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Publikováno v:
Neurocritical care. 37(Suppl 1)
Background: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expanding the neuronal damage. This period represents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387717c543a73baedf45c49185541c21
https://pubmed.ncbi.nlm.nih.gov/35194729
https://pubmed.ncbi.nlm.nih.gov/35194729
Publikováno v:
Cereb Cortex
Two major pathogenic events that cause acute brain damage during neurologic emergencies of stroke, head trauma, and cardiac arrest are spreading depolarizing waves and the associated brain edema that course across the cortex injuring brain cells. Vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc8283033854b46bcd82852a2d11fa6
https://pubmed.ncbi.nlm.nih.gov/32483593
https://pubmed.ncbi.nlm.nih.gov/32483593
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:1626-1633
Spreading depolarization-induced focal dendritic swelling (beading) is an early hallmark of neuronal cytotoxic edema. Pyramidal neurons lack membrane-bound aquaporins posing a question of how water enters neurons during spreading depolarization. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab76e2d593d8086ca3a71e112f12a733
https://doi.org/10.1177/0271678x16639328
https://doi.org/10.1177/0271678x16639328
Autor:
Frank Richter, Sergei A. Kirov, Cenk Ayata, Maren K.L. Winkler, Jens P. Dreier, Jed A. Hartings, Eric Rosenthal, Renán Sánchez-Porras, Christoph Drenckhahn, Raimund Helbok, Brandon Foreman, Oliver W. Sakowitz, Anja Urbach, Johannes Woitzik, Otto W. Witte, Jason M. Hinzman, R. David Andrew, Markus Dahlem, C. William Shuttleworth, Anthony J. Strong, Ana I Oliveira-Ferreira, Kevin C. Brennan, M. Brandon Westover, Eszter Farkas, Delphine Feuerstein, Rudolf Graf, Michael Schöll, Martyn G. Boutelle, Andrew P. Carlson, Martin Lauritzen, Edgar Santos, Christian Dohmen, Sebastian Major, Martin Fabricius
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:1571-1594
A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on Aristides Leão’s historic discoveries of spreading depression and asphyxial/anoxic depolarization. Treated as separate entities for decades, we no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb112d2b0a5e78de61169dafc70107f9
https://doi.org/10.1177/0271678x16654495
https://doi.org/10.1177/0271678x16654495
Publikováno v:
The Journal of Neuroscience. 35:12172-12187
Spreading depolarizations (SDs) are waves of sustained neuronal and glial depolarization that propagate massive disruptions of ion gradients through the brain. SD is associated with migraine aura and recently recognized as a novel mechanism of injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96cc6477f983e0e176cbd8afe5a7dca
https://doi.org/10.1523/jneurosci.0400-15.2015
https://doi.org/10.1523/jneurosci.0400-15.2015