Investigating the molecular pharmacology of the short chain fatty acid receptor FFA2

Autor: Sergeev, Eugenia

The G protein-coupled receptor FFA2 is a key mediator of short chain fatty acid signalling, which are produced in the gut via fermentation of poorly digested carbohydrates by the gut microbiota. Therefore, FFA2 has attracted interest as a potential t

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744094

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A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Autor: Sergeev, Eugenia, Hansen, Anders Højgaard, Bolognini, Daniele, Kawakami, Kouki, Kishi, Takayuki, Aoki, Junken, Ulven, Trond, Inoue, Asuka, Hudson, Brian D., Milligan, Graeme

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Sergeev, E, Hansen, A H, Bolognini, D, Kawakami, K, Kishi, T, Aoki, J, Ulven, T, Inoue, A, Hudson, B D & Milligan, G 2017, ' A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias ', Scientific Reports, vol. 7, 13741 . https://doi.org/10.1038/s41598-017-14096-3

Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates. A major challenge in studying this receptor is that the mouse ortholog does

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9b2489b721960b9f4875e9f8e3e48742
https://eprints.gla.ac.uk/149058/1/149058.pdf

A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias

Autor: Bolognini, Daniele, Moss, Catherine E., Nilsson, Karolina, Petersson, Annika U., Donnelly, Iona, Sergeev, Eugenia, König, Gabriele M., Kostenis, Evi, Kurowska-Stolarska, Mariola, Miller, Ashley, Dekker, Niek, Tobin, Andrew B., Milligan, Graeme

The short chain fatty acid receptor FFA2 is able to stimulate signalling via both Gi and Gqv/G11-promoted pathways. These pathways are believed to control distinct physiological endpoints but FFA2 receptor ligands appropriate to test this hypothesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4bc93ff86ee906091665ecdccc40bcce
https://eprints.gla.ac.uk/111475/1/111475.pdf