Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Serge van Calenbergh"'
Autor:
Cassandra Present, Roberson Donola Girão, Cai Lin, Guy Caljon, Serge Van Calenbergh, Otacilio Moreira, Leonardo Alexandre de Souza Ruivo, Marcos Meuser Batista, Raquel Azevedo, Denise da Gama Jaen Batista, Maria de Nazaré Correia Soeiro
Publikováno v:
Parasitology, Vol 151, Pp 506-513 (2024)
Leishmania is a trypanosomatid parasite that causes skin lesions in its cutaneous form. Current therapies rely on old and expensive drugs, against which the parasites have acquired considerable resistance. Trypanosomatids are unable to synthesize pur
Externí odkaz:
https://doaj.org/article/fdbc09b2ce2b46c1a1ac11bb0c9763fd
Autor:
Frits van Charante, David Martínez-Pérez, Clara Guarch-Pérez, Charlotte Courtens, Andrea Sass, Emilia Choińska, Joanna Idaszek, Serge Van Calenbergh, Martijn Riool, Sebastian A.J. Zaat, Wojciech Święszkowski, Tom Coenye
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107557- (2023)
Summary: Acinetobacter baumannii causes a wide range of infections, including wound infections. Multidrug-resistant A. baumannii is a major healthcare concern and the development of novel treatments against these infections is needed. Fosmidomycin is
Externí odkaz:
https://doaj.org/article/2eda2ca92bf3457d91935bbb9aaee401
Autor:
Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 21-30 (2022)
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleos
Externí odkaz:
https://doaj.org/article/67220a1220024591ad64ccc816d06c7e
Autor:
Cai Lin, Fabian Hulpia, Izet Karalic, Laurens De Schepper, Louis Maes, Guy Caljon, Serge Van Calenbergh
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 57-66 (2021)
Kinetoplastid parasites are the causative agents of Chagas disease (CD), leishmaniasis and human African trypanosomiasis (HAT). Despite a sustained decrease in the number of HAT cases, more efforts are needed to discover safe and effective therapies
Externí odkaz:
https://doaj.org/article/a482b44f49a740799353ff42d4fea40a
Autor:
Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1503-1512 (2020)
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The en
Externí odkaz:
https://doaj.org/article/583b2f06989a4d3d8e2f03ed4b6cde5e
Autor:
Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with
Externí odkaz:
https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
Autor:
Evelien Wynendaele, Christophe Furman, Bartosz Wielgomas, Per Larsson, Eelko Hak, Thomas Block, Serge Van Calenbergh, Nicolas Willand, Michal Markuszewski, Luke R. Odell, Gerrit J. Poelarends, Bart De Spiegeleer
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss , Pp 100107- (2021)
Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly
Externí odkaz:
https://doaj.org/article/5a33ad31471a408795ab5e204a5d6c7d
Autor:
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning
Publikováno v:
Molecules, Vol 27, Iss 22, p 8045 (2022)
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurin
Externí odkaz:
https://doaj.org/article/dcdfd03943c144409fdee59cfd36c9d5
Autor:
Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girão, Fabian Hulpia, Paula Finamore-Araújo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacílio Moreira, Serge Van Calenbergh, Maria de Nazaré C. Soeiro
Publikováno v:
Molecules, Vol 27, Iss 22, p 8087 (2022)
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem. Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious efficacy and safety drawbacks. Nucleoside analogues represent a
Externí odkaz:
https://doaj.org/article/876b03b2f5ac4a6a80705f7e7691022f
Autor:
Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel
Externí odkaz:
https://doaj.org/article/ddd72678135941fdb84362715749b1f1