Výsledky vyhledávání - "Serge Yarovoi"

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits

Autor: Ali Azghani, Steven Idell, Chris Schaefer, Douglas B. Cines, Serge Yarovoi, Paul Declerck, Sophia Karandashova, Andrey A. Komissarov, Galina Florova

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 314:L54-L68

Elevated active plasminogen activator inhibitor-1 (PAI-1) has an adverse effect on the outcomes of intrapleural fibrinolytic therapy (IPFT) in tetracycline-induced pleural injury in rabbits. To enhance IPFT with prourokinase (scuPA), two mechanistica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5492aec19bf521c5a256824d2157e40b
https://doi.org/10.1152/ajplung.00579.2016

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Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Autor: Mortimer Poncz, Lubica Rauova, Sanjay Khandelwal, Douglas B. Cines, Amrita Sarkar, Serge Yarovoi, Gowthami M. Arepally

Publikováno v: Blood. 138:581-581

Heparin induced thrombocytopenia (HIT) is an immunogenic prothrombotic disorder caused by antibodies that recognize human platelet factor 4 (PF4) complexed to polyanions. We had previously shown using chimeric constructs of hPF4 and mouse (m) PF4 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff771f74eabfcbdacbe8fbb3352744d7
https://doi.org/10.1182/blood-2021-146233

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Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Autor: Sanjay Khandelwal, Charles S. Abrams, Serge Yarovoi, Matthew D. Weitzman, Andreas Tiede, Matthew J. Charman, Douglas B. Cines, Lubica Rauova, Gowthami M. Arepally, Andy Wang, Olga Oleshko, Anand Padmanabhan, Mortimer Poncz

Publikováno v: Blood. 138:292-292

VITT is an immune-based complication of adenoviral-based vaccines used to immunize against SARS_CoV2. The antibodies in VITT have been described as directed at the platelet-specific chemokine PF4 (CXCL4). While the clinical course and target chemokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4870eac96429c15c5b4204c2e48c571d
https://doi.org/10.1182/blood-2021-151685

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tPA variant tPA-A296-299Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1

Autor: Abd Al-Roof Higazi, Hugh Hekierski, Douglas B. Cines, William M. Armstead, Serge Yarovoi

Publikováno v: Journal of Neuroscience Research. 96:128-137

Tissue-type plasminogen activator (tPA) is neurotoxic and exacerbates uncoupling of cerebral blood flow (CBF) and metabolism after stroke, yet it remains the sole FDA-approved drug for treatment of ischemic stroke. Upregulation of c-Jun-terminal kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::252d45f827a59d3f94d958f5a049cc34
https://doi.org/10.1002/jnr.24112

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Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Autor: Mortimer Poncz, Douglas B. Cines, Ann H. Rux, Sanjay Khandelwal, Sooho Samuel Myoung, Gowthami M. Arepally, Serge Yarovoi, Lubica Rauova, Madelaine Duarte, Ayiesha Barnes, Alexandra Johnson, Grace M. Lee

Publikováno v: Blood. 136:11-12

Heparin induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies bound to multivalent complexes of platelet factor 4 (PF4) and heparin (H). HIT ULICs activate cellular FcγI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5236ea172799aa2c712b6185087ec05d
https://doi.org/10.1182/blood-2020-138631

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Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Autor: Douglas B. Cines, Hugh Kim, Serge Yarovoi, Adam Cuker, Cecilia Guo, Tatiana Lebedeva, Richard J. Travers, Linnette Mae Ocariza, Mortimer Poncz, Sanjay Khandelwal, James H. Morrissey, Lubica Rauova, Gowthami M. Arepally, Sergei Zaitsev, Stephanie A. Smith, Victoria Stepanova, Edward M. Conway, Ann H. Rux

Publikováno v: Blood Advances. 1:62-74

Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd11d6328f778e3cbd915f2945e920f
https://doi.org/10.1182/bloodadvances.2016000877

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Abstract TP251: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

Autor: Serge Yarovoi, Douglas B. Cines, William M. Armstead, Hugh Hekierski, Abd Al-Roof Higazi, Philip Pastor

Publikováno v: Stroke. 49

Introduction: The sole FDA approved drug treatment for acute stroke is tissue type plasminogen activator (tPA). However, its brief therapeutic window and post-treatment complications markedly constrain its use. Upregulation of JNK MAPK and ET-1 by ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7600f4384c4692e5d58f0bef25aeea7e
https://doi.org/10.1161/str.49.suppl_1.tp251

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tPA variant tPA-A

Autor: William M, Armstead, Hugh, Hekierski, Serge, Yarovoi, Abd Al-Roof, Higazi, Douglas B, Cines

Publikováno v: Journal of neuroscience research. 96(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b87f5b89249fc3fc08c8b1ca376a9041
https://pubmed.ncbi.nlm.nih.gov/28703856

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Abstract WP285: tPA Variant tPA-A296-299 Prevents Impairment of Cerebral Autoregulation and Hippocampal Neuronal Necrosis After Stroke Through Inhibition of ET-1 Upregulation

Autor: Hugh Hekierski, Abd Al-Roof Higazi, Douglas B. Cines, William M. Armstead, Serge Yarovoi

Publikováno v: Stroke. 48

Introduction: The sole FDA approved treatment for acute stroke is tissue type plasminogen activator (tPA). However, its brief therapeutic window and post-treatment complications markedly constrain its use. The limited efficacy of tPA may be explained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a00f71626892d72b3aa295ab347fb8e8
https://doi.org/10.1161/str.48.suppl_1.wp285

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