Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

Autor: Gaëlle Gonzalez, Sandrina DaFonseca, Elisabeth Errazuriz, Pascale Coric, Florence Souquet, Serge Turcaud, Pierre Boulanger, Serge Bouaziz, Saw See Hong

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27234 (2011)

The HIV-1 auxiliary protein Vpr and Vpr-fusion proteins can be copackaged with Gag precursor (Pr55Gag) into virions or membrane-enveloped virus-like particles (VLP). Taking advantage of this property, we developed a simple and sensitive method to eva

Externí odkaz: https://doaj.org/article/3cd2480a46d64552b560e821c1be7403

Insight into the mechanism of action of EP-39, a bevirimat derivative that inhibits HIV-1 maturation

Autor: Aymeric Neyret, Bernard Gay, Anaïs Cransac, Laurence Briant, Pascale Coric, Serge Turcaud, Philippe Laugâa, Serge Bouaziz, Nathalie Chazal

Publikováno v: Antiviral Research
Antiviral Research, Elsevier Masson, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩
Antiviral Research, 2019, 164, pp.162-175. ⟨10.1016/j.antiviral.2019.02.014⟩

International audience; Maturation of human immunodeficiency virus type 1 (HIV-1) particles is a key step for viral infectivity. This process can be blocked using maturation inhibitors (MIs) that affect the cleavage of the capsid-spacer peptide 1 (CA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5ed1c5e94c5c23aebd0b7c278b620
https://hal.archives-ouvertes.fr/hal-02147099/file/1-s2.0-S0166354218307162-main(1).pdf

3D Coumarin Systems Based on [2.2]Paracyclophane Synthesis, Spectroscopic Characterization, and Chiroptical Properties

Autor: Corentin Reynaud, Laurent Micouin, Jeanne Crassous, Ludovic Favereau, Erica Benedetti, Marie-Léonie Delcourt, Serge Turcaud

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (2), pp.888-899. ⟨10.1021/acs.joc.8b02773⟩
Journal of Organic Chemistry, 2019, 84 (2), pp.888-899. ⟨10.1021/acs.joc.8b02773⟩

International audience; In this article, we report the preparation of a series of [2.2]paracyclophane-fused coumarin systems through a simple and general procedure involving a transition-metal-catalyzed cyclization of aryl alkynoates as the key step.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb51dfe992d4bdb23cb8ca2ba978aba
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02049506

Efficient and Scalable Kinetic Resolution of Racemic 4-Formyl[2.2]paracyclophaneviaAsymmetric Transfer Hydrogenation

Autor: Laurent Micouin, Erica Benedetti, Serge Turcaud, Marie-Léonie Delcourt

Publikováno v: Advanced Synthesis & Catalysis. 358:1213-1218

Herein we wish to report a new non-enzymatic kinetic resolution of racemic 4-formyl[2.2]paracyclophane based on Noyori asymmetric transfer hydrogenations (KR-ATH). Our approach, which provides an efficient access to enantiopure (Rp)- and (Sp)-4-formy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79c61ab0cf788de2d06bf1217a2eac29
https://doi.org/10.1002/adsc.201501153

Synthesis and photophysical studies of through-space conjugated [2.2]paracyclophane-based naphthalene fluorophores

Autor: Marie-Léonie Delcourt, B. Gatin-Fraudet, Laurent Micouin, Erica Benedetti, Serge Turcaud

Publikováno v: RSC Advances
RSC Advances, Royal Society of Chemistry, 2017, 7 (80), pp.50472-50476. ⟨10.1039/C7RA10038H⟩

International audience; In this work we report a straightforward method for the synthesis of a new class of small organic fluorophores bearing both [2.2]paracyclophane and naphthalene subunits using an intramolecular dehydrogenative Diels-Alder react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916237fd54fed360e6de873453421985
https://hal.archives-ouvertes.fr/hal-02113405