Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Serge Summermatter"'
Autor:
Giuseppe Locatelli, Martin Stangel, Daniel Rooks, Julian Boesch, Eliane Pierrel, Serge Summermatter
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system (CNS) with subsequent axonal and neuronal degeneration. These changes are associated with a broad range of symptoms
Externí odkaz:
https://doaj.org/article/a1c10e2904b64b32afe4b52acd3d84de
Autor:
Julian Boesch, Eliane Pierrel, Christian Lambert, Arno Doelemeyer, Julie Kreider, Nathalie Accart, Serge Summermatter
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Musculoskeletal diseases are a leading contributor to mobility disability worldwide. Since the majority of patients with musculoskeletal diseases present with associated muscle weakness, treatment approaches typically comprise an element of resistanc
Externí odkaz:
https://doaj.org/article/ade58419ce634cddb69d6ad1b7cc9b16
Autor:
Elisa Giorgetti, Moh Panesar, Yunyu Zhang, Stefanie Joller, Marie Ronco, Michael Obrecht, Christian Lambert, Nathalie Accart, Nicolau Beckmann, Arno Doelemeyer, Ludovic Perrot, Isabelle Fruh, Matthias Mueller, Eliane Pierrel, Serge Summermatter, Michael Bidinosti, Derya R. Shimshek, Sophie Brachat, Mark Nash
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1539-1554.e7 (2019)
Summary: Age-related loss of skeletal muscle innervation by motor neurons leads to impaired neuromuscular function and is a well-established clinical phenomenon. However, the underlying pathogenesis remains unclear. Studying mice, we find that the nu
Externí odkaz:
https://doaj.org/article/13d82a5330874e21a85e5781c1bb0dd9
Autor:
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 749-763.e12 (2019)
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylas
Externí odkaz:
https://doaj.org/article/9e48897b13e34703b8199ceb48040546
Autor:
Nathalie Burch, Anne-Sophie Arnold, Flurin Item, Serge Summermatter, Gesa Brochmann Santana Santos, Martine Christe, Urs Boutellier, Marco Toigo, Christoph Handschin
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10970 (2010)
Adequate levels of physical activity are at the center of a healthy lifestyle. However, the molecular mechanisms that mediate the beneficial effects of exercise remain enigmatic. This gap in knowledge is caused by the lack of an amenable experimental
Externí odkaz:
https://doaj.org/article/1c24b1135b604c1baef418669c70a2e0
Publikováno v:
Biochemical and Biophysical Research Communications. 503:2415-2420
The majority of patients with advanced cancer suffer from cachexia, a systemic wasting syndrome, which subsequently impacts the tolerance to anti-cancer treatments, response to therapy, quality of life, and eventually, survival. Despite a high unmet
Autor:
Anna Lena Engeli, Serge Summermatter, Oliver Baum, Andreas Zakrzewicz, Matthias Spree, Dea Aaldijk, Christoph Handschin
The expression of neuronal NO synthase (nNOS) alpha- and beta-isoforms in skeletal muscle is well documented but only little information is available about their regulation/functions. Using different mouse models, we now assessed whether the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61089d160d11e56595903b7d4cf8a07e
https://edoc.unibas.ch/64314/
https://edoc.unibas.ch/64314/
Autor:
Christina Dornelas, Sabine Gutzwiller, Serge Summermatter, Erin Nolin, David J. Glass, Eliane Pierrel, Christy Fryer, Juliet Leighton-Davies, Stefan Melly, Daniela Stauffer, Brigitte Fournier, Anais Bouzan
Publikováno v:
Molecular and Cellular Biology. 37
Metallothioneins are proteins that are involved in intracellular zinc storage and transport. Their expression levels have been reported to be elevated in several settings of skeletal muscle atrophy. We therefore investigated the effect of metallothio
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) controls metabolic adaptations. We now show that PGC-1α in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-α–depend
Autor:
Françoise Rohner-Jeanrenaud, Delphine Sarafian, Jean-Pierre Montani, Jennifer L. Miles-Chan, Fabio Zani, Christelle Veyrat-Durebex, Giovanni Solinas, Josiane Seydoux, Serge Summermatter, Helena Marcelino, Abdul G. Dulloo, Denis Arsenijevic
Publikováno v:
Diabetes. 62:362-372
Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a lo