Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Serge P Bottari"'
Autor:
Zine‐Eddine Kherraf, Marie Christou‐Kent, Thomas Karaouzene, Amir Amiri‐Yekta, Guillaume Martinez, Alexandra S Vargas, Emeline Lambert, Christelle Borel, Béatrice Dorphin, Isabelle Aknin‐Seifer, Michael J Mitchell, Catherine Metzler‐Guillemain, Jessica Escoffier, Serge Nef, Mariane Grepillat, Nicolas Thierry‐Mieg, Véronique Satre, Marc Bailly, Florence Boitrelle, Karin Pernet‐Gallay, Sylviane Hennebicq, Julien Fauré, Serge P Bottari, Charles Coutton, Pierre F Ray, Christophe Arnoult
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1132-1149 (2017)
Abstract Azoospermia, characterized by the absence of spermatozoa in the ejaculate, is a common cause of male infertility with a poorly characterized etiology. Exome sequencing analysis of two azoospermic brothers allowed the identification of a homo
Externí odkaz:
https://doaj.org/article/acfdace776ce4e4b925803c814b43c54
Autor:
Marie Christou‐Kent, Zine‐Eddine Kherraf, Amir Amiri‐Yekta, Emilie Le Blévec, Thomas Karaouzène, Béatrice Conne, Jessica Escoffier, Said Assou, Audrey Guttin, Emeline Lambert, Guillaume Martinez, Magalie Boguenet, Selima Fourati Ben Mustapha, Isabelle Cedrin Durnerin, Lazhar Halouani, Ouafi Marrakchi, Mounir Makni, Habib Latrous, Mahmoud Kharouf, Charles Coutton, Nicolas Thierry‐Mieg, Serge Nef, Serge P Bottari, Raoudha Zouari, Jean Paul Issartel, Pierre F Ray, Christophe Arnoult
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 5, Pp n/a-n/a (2018)
Abstract The genetic causes of oocyte meiotic deficiency (OMD), a form of primary infertility characterised by the production of immature oocytes, remain largely unexplored. Using whole exome sequencing, we found that 26% of a cohort of 23 subjects w
Externí odkaz:
https://doaj.org/article/2a2704a3d4124064a7b9b19a154a9916
Autor:
Matthias Oelze, Swenja Kröller-Schön, Philipp Welschof, Thomas Jansen, Michael Hausding, Yuliya Mikhed, Paul Stamm, Michael Mader, Elena Zinßius, Saule Agdauletova, Anna Gottschlich, Sebastian Steven, Eberhard Schulz, Serge P Bottari, Eric Mayoux, Thomas Münzel, Andreas Daiber
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112394 (2014)
OBJECTIVE: In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), offers a novel approach for the treatm
Externí odkaz:
https://doaj.org/article/89298fb08472410b8081d15236c79a94
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10070 (2010)
Angiotensin II (Ang II) plays a major role in the pathogenesis of insulin resistance and diabetes by inhibiting insulin's metabolic and potentiating its trophic effects. Whereas the precise mechanisms involved remain ill-defined, they appear to be as
Externí odkaz:
https://doaj.org/article/41f9b6392fb64e2282e42a527d25b70e
It is now well accepted that most chronic diseases have a common feature which is “low-grade” inflammation. Whether inflammation is causal or rather consequent to these diseases is still a matter of debate. A key factor of inflammation is conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cf439deef4906a76cf1481d43c8c8e
Autor:
Candice Trocmé, Nicolas Gonnet, Margaux Di Tommaso, Hanen Samouda, Jean-Luc Cracowski, Claire Cracowski, Stéphanie Lambert-Porcheron, Martine Laville, Estelle Nobécourt, Chiraz Gaddhab, Allan Le Lay, Torsten Bohn, Christine Poitou, Karine Clément, Fahd Al-Mulla, Milad S. Bitar, Serge P. Bottari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, 2021, 7, ⟨10.3389/fmolb.2020.596141⟩
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, 2021, 7, ⟨10.3389/fmolb.2020.596141⟩
International audience; Insulin resistance (IR), currently called prediabetes (PD), affects more than half of the adult population worldwide. Type 2 diabetes (T2D), which often follows in the absence of treatment, affects more than 475 million people
Autor:
Karl J. Lackner, Siyer Roohani, Maximilian Kopp, Philipp Welschof, Serge P. Bottari, Andreas Daiber, Matthias Oelze, Philip Wenzel, Ning Xia, Ute Gödtel-Armbrust, Eric Mayoux, Huige Li, Leszek Wojnowski, Thomas Münzel, Swenja Kröller-Schön, Sebastian Steven, Alina Hanf, Eberhard Schulz, Fatemeh Kashani
Publikováno v:
Redox Biology
Redox Biology, Vol 13, Iss C, Pp 370-385 (2017)
Redox Biology, Vol 13, Iss C, Pp 370-385 (2017)
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (J
Autor:
Ana Čipak Gašparović, Olha Yelisyeyeva, Danylo Kaminskyy, Serge P. Bottari, Neven Zarkovic, Kamelija Zarkovic, Khrystyna Semen
Publikováno v:
British Journal of Pharmacology. 174:1771-1783
The concept of oxidative stress (OS) that connects altered redox biology with various diseases was introduced 30 years ago and has generated intensive research over the past two decades. Whereas it is now commonly accepted that macromolecule oxidatio
Autor:
George Kokotos, Pierre F. Ray, Serge P. Bottari, Sylviane Hennebicq, Jessica Escoffier, Gérard Lambeau, Jean-Pascal Hograindleur, Guillaume Martinez, Christophe Arnoult, John Turk, Sandra Yassine, Roland Abi Nahed, Thomas Karaouzène
Publikováno v:
Journal of Biological Chemistry. 291:3076-3089
Phospholipase A2 (PLA2) activity has been shown to be involved in the sperm acrosome reaction (AR), but the molecular identity of PLA2 isoforms has remained elusive. Here, we have tested the role of two intracellular (iPLA2β and cytosolic PLA2α) an
Publikováno v:
Current opinion in toxicology
Macromolecule oxidation in response to reactive oxygen species (ROS) is associated with a variety of diseases. The recognition of NO as a key regulator of redox signalling has more recently led to the discovery that reactive nitrogen species (RNS) al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741bd3d8dbeeb290437439822099c13
http://fulir.irb.hr/5677/2/gasparovic2017.pdf
http://fulir.irb.hr/5677/2/gasparovic2017.pdf