Výsledky vyhledávání

Methods to identify and characterize iron–sulfur oligopeptides in water

Autor: Luca Valer, Daniele Rossetto, Simone Scintilla, Yin Juan Hu, Anju Tomar, Serge Nader, Isaiah O. Betinol, Sheref S. Mansy

Publikováno v: Canadian Journal of Chemistry. 100:475-483

Iron–sulfur clusters are ubiquitous cofactors that mediate central biological processes. However, despite their long history, these metallocofactors remain challenging to investigate when coordinated to small (≤ six amino acids) oligopeptides in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba7959a401433000a2c5051036e208a
https://doi.org/10.1139/cjc-2021-0237

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Racing toward Fast and Effective 17O Isotopic Labeling and Nuclear Magnetic Resonance Spectroscopy of N-Formyl-MLF-OH and Associated Building Blocks

Autor: Jochem Struppe, Job Boekhoven, Serge Nader, Martine Monette, Shane Pawsey, Vladimir K. Michaelis, Michelle Ha, Sheref S. Mansy

Publikováno v: The Journal of Physical Chemistry B. 125:11916-11926

Solid-state 1H, 13C, and 15N nuclear magnetic resonance (NMR) spectroscopy has been an essential analytical method in studying complex molecules and biomolecules for decades. While oxygen-17 (17O) NMR is an ideal and robust candidate to study hydroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f33b8cde6c4059a52d44364183b0ec08
https://doi.org/10.1021/acs.jpcb.1c07397

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Protometabolism as out-of-equilibrium chemistry

Autor: Sheref Mansy, Lorenzo Sebastianelli, Serge Nader

Publikováno v: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. 380(2227)

It is common to compare life with machines. Both consume fuel and release waste to run. In biology, the engine that drives the living system is referred to as metabolism. However, attempts at deciphering the origins of metabolism do not focus on this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e56df902e169d88dd627c6fc2593ef8
https://pubmed.ncbi.nlm.nih.gov/35599565

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Racing toward Fast and Effective

Autor: Michelle, Ha, Serge, Nader, Shane, Pawsey, Jochem, Struppe, Martine, Monette, Sheref S, Mansy, Job, Boekhoven, Vladimir K, Michaelis

Publikováno v: The journal of physical chemistry. B. 125(43)

Solid-state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ab87ce7d5948882a04b764c2eb07b71
https://pubmed.ncbi.nlm.nih.gov/34694819

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Spectral decomposition of iron-sulfur clusters

Autor: Serge Nader, Sheref S. Mansy, Isaiah O. Betinol

Publikováno v: Analytical biochemistry. 629

The near universal availability of UV-Visible spectrophotometers makes this instrument a highly exploited tool for the inexpensive, rapid examination of iron-sulfur clusters. Yet, the analysis of iron-sulfur cluster reconstitution experiments by UV-V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39d573424f92925885da20af54a3138
https://pubmed.ncbi.nlm.nih.gov/34089700

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New insights into the tetrameric family of the Fur metalloregulators

Autor: Isabelle Michaud-Soret, Serge Crouzy, L. Arnaud, Philippe Carpentier, Serge Nader, Julien Pérard

Publikováno v: BioMetals
BioMetals, 2019, 32 (3), pp.501-519. ⟨10.1007/s10534-019-00201-8⟩
BioMetals, Springer Verlag, 2019, 32 (3), pp.501-519. ⟨10.1007/s10534-019-00201-8⟩

International audience; The ferric uptake regulator (Fur) belongs to the family of the metal-responsive transcriptional regulators. Fur is a global regulator found in all proteobacteria. It controls the transcription of a wide variety of genes involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fe62d33720e5029bc2787076d004c3
https://hal.science/hal-02166207

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Structural studies on inhibition mechanisms, oligomerization and DNA binding of the transcription regulator Fur : from in silico simulations to in vitro biological assays

Autor: Serge Nader

Publikováno v: Quantitative Methods [q-bio.QM]. Université Grenoble Alpes, 2018. English. ⟨NNT : 2018GREAV037⟩
HAL

The most commonly prescribed drugs in human medicine are antibiotics. Since their discovery, they have drastically impacted the way we treat infections. However, a bacterium eventually becomes resistant to antimicrobial treatment through the natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e2f4e02aea720b4664d2dd096d98acf7
https://tel.archives-ouvertes.fr/tel-02050234

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Calibration of 1,2,4-Triazole-3-Thione, an Original Zn-Binding Group of Metallo-β-Lactamase Inhibitors. Validation of a Polarizable MM/MD Potential by Quantum Chemistry

Autor: Mirna Damergi, Serge Nader, Zeina Hobaika, Karolina Kwapien, Richard G. Maroun, Jean-Philip Piquemal, Laurent Gavara, Jean-François Hernandez, Nohad Gresh, Dorothée Berthomieu, Léa El Khoury

Publikováno v: Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2017, 121 (26), pp.6295-6312. ⟨10.1021/acs.jpcb.7b01053⟩
Journal of Physical Chemistry B, 2017, 121 (26), pp.6295-6312. ⟨10.1021/acs.jpcb.7b01053⟩

In the context of the SIBFA polarizable molecular mechanics/dynamics (PMM/PMD) procedure, we report the calibration and a series of validation tests for the 1,2,4-triazole-3-thione (TZT) heterocycle. TZT acts as the chelating group of inhibitors of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677c34f6419e738f37200aa15870b8f7
https://hal.archives-ouvertes.fr/hal-02126854

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