[3H]-Trimetazidine mitochondrial binding sites: regulation by cations, effect of trimetazidine derivatives and other agents and interaction with an endogenous substance

Autor: Alain Le Ridant, Aziz Elimadi, Jean-Paul Tillement, Serge Labidalle, Bernard Testa, Didier Morin, Rosa Sapena

Publikováno v: British Journal of Pharmacology. 130:655-663

Trimetazidine, an antiischaemic drug, has been shown to restore impaired mitochondrial functions. Specific binding sites for [3H]-trimetazidine have been previously detected in liver mitochondria. In the present study we confirm this observation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::558a3b1043e95dd5c30f823c4c1cfda0
https://doi.org/10.1038/sj.bjp.0703348

SYNTHESIS AND CHARACTERIZATION OF NEW AROMATIC THIONITRITES

Autor: Pascal Hoffmann, Jean-Pierre Souchard, Catherine Petit, Serge Labidalle

Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 129:59-67

Thionitrites (S-nitrosothiols) play an essential biological role as nitric oxide (NO.) carriers. Here, we present the synthesis. the characterization and the stability studies in solution of new aromatic thionitrites 1b-4b as potent nitric oxide dono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42075b829073f6fcf73cce751fac414d
https://doi.org/10.1080/10426509708031580

Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore

Autor: Sophie Barthélémy, Roland Zini, Jean-Paul Tillement, Heidi Ligeret, Serge Labidalle, Didier Morin

Publikováno v: Free radical biologymedicine. 36(7)

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a natural compound with antiproliferative properties. Recent studies suggest that these properties might be due to the ability of curcumin to induce apoptosis in tumor cells by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0fe61abbff5a3a0c83bee6c2150a0e
https://pubmed.ncbi.nlm.nih.gov/15019976

[3H]BHDP as a novel and selective ligand for δ1 receptors in liver mitochondria and brain synaptosomes of the rat

Autor: Serge Labidalle, Brigitte Onteniente, Michel Wierzbicki, Vincent Berezowski, Roméo Cecchelli, Jean-Paul Tillement, Anis Klouz, Didier Morin, Marie-Francoise Boussard

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2003, 553, p. 157-162

International audience; The binding profile of [3H]BHDP [3H]N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine) was evaluated. [3H]BHDP labelled a single class of binding sites with high affinity (Kd = 2-3 nM) in rat liver mitochondria and synapt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b68eb78b90313c7e9c5f9385f6aa42
https://hal-univ-artois.archives-ouvertes.fr/hal-00537718

Antioxidant activity of phenolic acids and esters present in red wine on human Low-Density Lipoproteins

Autor: Pascale Urizzi, Annie Abella, Jean-Pierre Souchard, Jacqueline Chalas, Serge Labidalle, Laurent Vergnes, Albert Lindenbaum, Françoise Nepveu, Marie-Carmen Monje

Publikováno v: Journal de Chimie Physique et de Physico-Chimie Biologique
Journal de Chimie Physique et de Physico-Chimie Biologique, EDP Sciences, 1999, 96 (1), pp.110-115. ⟨10.1051/jcp:1999117⟩

International audience; To evaluate the antioxidant activity of different phenolic acids and their esters, three types of experiments have been used. Electron paramagnetic resonance (EPR) quantitative analysis was carried out using the acetaldehyde/x

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874ae13989c57d00751e7d59107d3c58
https://hal.archives-ouvertes.fr/hal-02143187