Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Serge L. Beaucage"'
Autor:
Montserrat Puig, Suryatheja Ananthula, Ramesh Venna, Swamy Kumar Polumuri, Elliot Mattson, Lacey M. Walker, Marco Cardone, Mayumi Takahashi, Shan Su, Lisa F. Boyd, Kannan Natarajan, Galina Abdoulaeva, Wells W. Wu, Gregory Roderiquez, William H. Hildebrand, Serge L. Beaucage, Zhihua Li, David H. Margulies, Michael A. Norcross
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial
Externí odkaz:
https://doaj.org/article/57a65f7c16ba491cbcf73a5ec2561268
Autor:
Serge L. Beaucage
Publikováno v:
Open Access Government. 36:216-218
What are the possibilities of DNA and RNA sequences? Synthetic DNA and RNA sequences are currently being used as nucleic-acid-based drugs for the treatment of a plethora of human diseases under antisense and/or RNA interference therapies. This articl
Autor:
Serge L. Beaucage
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95956200be861b43d55b50bc89fcf247
https://doi.org/10.1016/b978-0-12-821618-7.00238-8
https://doi.org/10.1016/b978-0-12-821618-7.00238-8
Publikováno v:
Current Protocols. 3
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 152:1361-1367
We describe the hybrid enzymatic and chemical synthesis of a 2′-O-cyanoethoxymethyl (CEM) [1′,6-13C2, 5-2H]-uridine phosphoramidite (amidite). This is the first report of an atom-specific nucleobase and ribose labeled CEM amidite. Importantly, th
Publikováno v:
Current protocolsLiterature Cited. 2(7)
A combined enzymatic and chemical synthesis of a 2'-O-cyanoethoxymethyl (CEM) protected [1',6
Publikováno v:
The Journal of Organic Chemistry. 86:4944-4956
The implementation of protecting groups for the 2'-hydroxyl function of ribonucleosides is still challenging, particularly when RNA sequences must be of the highest purity for therapeutic applications as nucleic acid-based drugs. A 2'-hydroxyl-protec
Autor:
Serge L. Beaucage
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
Publikováno v:
Current protocolsLiterature Cited. 2(1)
The implementation of protecting groups for 2'-hydroxyl function of ribonucleosides is very demanding in that synthetic RNA sequences must be highly pure to ensure the safety and efficacy of nucleic acid-based drugs for treatment of human diseases. A
Publikováno v:
Tetrahedron Letters. 106:154077