Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Serge Gueroussov"'
Autor:
Kohila Mahadevan, Hui Zhang, Abdalla Akef, Xianying A Cui, Serge Gueroussov, Can Cenik, Frederick P Roth, Alexander F Palazzo
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001545 (2013)
In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate translation in the presenc
Externí odkaz:
https://doaj.org/article/0c5c8dfdf40543e787124ba6c96ece5e
Autor:
Serge Gueroussov, Chengyin Min, Alan Huang, Samuel Meier, Jessica Finkler, Lei Ji, Ashley Choi, Tenzing Khendu, Disha Subramanya, Shangtao Liu, Binzhang Shen, Teng Teng, Xuewen Pan, Yi Yu
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Florian Le Billan, Stephane Angers, Mélanie Robitaille, Henry M. Krause, Quaid Morris, Carolyn L. Cummins, Debashish Ray, Vincent Boivin, Timothy P. Hughes, Benjamin J. Blencowe, Michelle S. Scott, Serge Gueroussov, Rucha Patel, Michael F. Saikali, Lilia Magomedova, Chao Xu, Emma Zilberman, Jens Tiefenbach, Pancharatnam Jeyasuria, Veronique Voisin, Gary D. Bader, Manuel Irimia
Publikováno v:
Nucleic Acids Research
Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modulators of glucocorticoid signaling in the CNS. Biochemical studies sh
Autor:
Anne-Claude Gingras, Robert J. Weatheritt, Ashrut Narula, Benjamin J. Blencowe, Zhen-Yuan Lin, Serge Gueroussov, Dave O'Hanlon
Publikováno v:
Cell. 170(2)
Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are enriched in transcript seque
Autor:
Ulrich Braunschweig, Alex M. Plocik, Brenton R. Graveley, Benjamin J. Blencowe, Serge Gueroussov
Publikováno v:
Cell. 152(6):1252-1269
Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription,
Autor:
Anne-Claude Gingras, Bushra Raj, Thomas Gonatopoulos-Pournatzis, Benjamin J. Blencowe, Zhen-Yuan Lin, Serge Gueroussov, Manuel Irimia
Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants are largely unknown. Here we show that mammalian-specific skipping of polypyrimidine tract-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bf807efb802a935f2ae2587f4e247e
http://hdl.handle.net/10230/27120
http://hdl.handle.net/10230/27120
Autor:
Quaid Morris, Yoseph Barash, Yimin Hua, Hannes Bretschneider, Hui Yuan Xiong, Benjamin J. Blencowe, Timothy P. Hughes, Serge Gueroussov, Stephen W. Scherer, Daniele Merico, Adrian R. Krainer, Leo J. Lee, Babak Alipanahi, Nebojsa Jojic, Brendan J. Frey, Hamed S. Najafabadi, Ryan K. C. Yuen
Predicting defects in RNA splicing Most eukaryotic messenger RNAs (mRNAs) are spliced to remove introns. Splicing generates uninterrupted open reading frames that can be translated into proteins. Splicing is often highly regulated, generating alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0b4fc412ee72b99a663a1a25a5e19
https://europepmc.org/articles/PMC4362528/
https://europepmc.org/articles/PMC4362528/
Autor:
D. Mecenas, Richard A. Anderson, Luiz O. F. Penalva, Matthew T. Weirauch, Hilal Kazan, Manuel Irimia, Seth M. Kelly, Benjamin J. Blencowe, Debashish Ray, Kate B. Cook, Serge Gueroussov, Quaid Morris, Howard D. Lipshitz, Behnam Nabet, Brendan J. Frey, Andrew G. Fraser, Russ P. Carstens, Hamed S. Najafabadi, Rakesh S. Laishram, Kristen W. Lynch, Leah H. Matzat, Elissa P. Lei, Ryan K. Dale, Hong Na, Christopher A. Yarosh, Fabio Piano, Xiao Li, Timothy P. Hughes, Anita H. Corbett, Mei Qiao, Weimin Li, Ally Yang, Mihai Albu, Hong Zheng, Sarah A. Smith
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have been functionally characterized. Here we report a systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0748e13e1846c83fd205b013c25f6ded
https://europepmc.org/articles/PMC3929597/
https://europepmc.org/articles/PMC3929597/
Autor:
Abdalla Akef, Alexander F. Palazzo, Serge Gueroussov, Frederick P. Roth, Can Cenik, Xianying A. Cui, Hui Zhang, Kohila Mahadevan
Publikováno v:
PLoS Biology
PLoS Biology, Vol 11, Iss 4, p e1001545 (2013)
PLoS Biology, Vol 11, Iss 4, p e1001545 (2013)
After nuclear export, mRNAs encoding secretory proteins interact with RanBP2/Nup358 on the cytoplasmic face of the nuclear pore, a step that is required for the efficient translation of these mRNAs.
In higher eukaryotes, most mRNAs that encode s
In higher eukaryotes, most mRNAs that encode s
Autor:
Nuno L. Barbosa-Morais, Stephen Watt, Claudia Kutter, Brendan J. Frey, Manuel Irimia, Benjamin J. Blencowe, Duncan T. Odom, Serge Gueroussov, Christine M. Misquitta-Ali, Hui Yuan Xiong, Philip M. Kim, Michael D. Wilson, TaeHyung Kim, Recep Colak, Qun Pan, Leo J. Lee, Valentina Slobodeniuc
Publikováno v:
Science (New York, N.Y.). 338(6114)
Whence Species Variation? Vertebrates have widely varying phenotypes that are at odds with their much more limited proteincoding genotypes and conserved messenger RNA expression patterns. Genes with multiple exons and introns can undergo alternative