Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Serge Boiteux"'
Publikováno v:
Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2017, 107, pp.179-201. ⟨10.1016/j.freeradbiomed.2016.11.042⟩
Free Radical Biology and Medicine, Elsevier, 2017, 107, pp.179-201. ⟨10.1016/j.freeradbiomed.2016.11.042⟩
International audience; Oxidatively damaged DNA results from the attack of sugar and base moieties by reactive oxygen species (ROS), which are formed as byproducts of normal cell metabolism and during exposure to endogenous or exogenous chemical or p
Autor:
Neil Hunter, Shangming Tang, Yunmei Ma, Kseniya Zakharyevich, Patty Yi Hwa Hwang, Serge Boiteux
Publikováno v:
Molecular Cell. 40(6):1001-1015
The Rad2/XPG family nuclease, Exo1, functions in a variety of DNA repair pathways. During meiosis, Exo1 promotes crossover recombination and thereby facilitates chromosome segregation at the first division. Meiotic recombination is initiated by progr
Autor:
Patricia Auffret van der Kemp, Helle D. Ulrich, Marcelo de Pádula, Guenaelle Burguiere-Slezak, Serge Boiteux
Publikováno v:
Nucleic Acids Research
7,8-Dihydro-8-oxoguanine (8-oxoG) is an abundant and mutagenic DNA lesion. In Saccharomyces cerevisiae, the 8-oxoG DNA N-glycosylase (Ogg1) acts as the primary defense against 8-oxoG. Here, we present evidence for cooperation between Rad18-Rad6-depen
Publikováno v:
Photochemistry and Photobiology. 76:640-648
The OGG1 proteins are DNA N-glycosylases–apurinic-apyrimidinic lyases that are responsible for the removal of 8-oxo-7,8-dihydroguanine (8-oxoG) base in DNA. The human enzyme (hOGG1) is a monomer of 345 amino acids containing 10 buried tryptophan (T
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2006, 34, pp.2056-66
Nucleic Acids Research, 2006, 34, pp.2056-2066. ⟨10.1093/nar/gkl139⟩
Nucleic Acids Research, 2006, 34, pp.2056-66
Nucleic Acids Research, 2006, 34, pp.2056-2066. ⟨10.1093/nar/gkl139⟩
We identified a viable allele (dut1-1) of the DUT1 gene that encodes the dUTPase activity in Saccharomyces cerevisiae. The Dut1-1 protein possesses a single amino acid substitution (Gly82Ser) in a conserved motif nearby the active site and exhibits a
Autor:
Caroline Elie, A. Reynaud-Angelin, Y. de Rycke, Stanislav G. Kozmin, G. Slezak, Serge Boiteux, Evelyne Sage
Publikováno v:
Proceedings of the National Academy of Sciences. 102:13538-13543
UVA (320-400 nm) radiation constitutes >90% of the environmentally relevant solar UV radiation, and it has been proposed to have a role in skin cancer and aging. Because of the popularity of UVA tanning beds and prolonged periods of sunbathing, the p
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩
Journal of Biological Chemistry, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩
Journal of Biological Chemistry, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines such as 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) from damaged DNA. Here, we report the crystal structure o
Publikováno v:
Journal of Radiation Research. 45:455-460
To improve the analyses of a form of oxidative DNA damage, 8-hydroxyguanine (8-OH-Gua), we treated isolated DNA with formamidopyrimidine DNA glycosylase (Fpg) and analyzed the released 8-OH-Gua by using a high-performance liquid chromatography system
Autor:
Serge Boiteux, Marie Guillet
Publikováno v:
DNA Repair. 3:1-12
Apurinic/apyrimidinic (AP) sites are one of the most frequent spontaneous lesions in DNA. They are potentially mutagenic and lethal lesions that can block DNA replication and transcription. In addition, cleavage of AP sites by AP endonucleases or AP
Autor:
Andrew Collins, Serge Boiteux, Jacques Laval, Zygmunt Ciesla, Barbara Tudek, Helmut Bartsch, Hideo Shinagawa, Katarzyna Bebenek, Leon F.H. Mullenders, Krzysztof Szyfter, Marcin Kruszewski, Celina Janion, Albert A. van Zeeland
Publikováno v:
DNA Repair. 2:765-781